Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Chemical Compound Review:

agropine 3-[(3S,6R)-2-oxo-6-(1,2,3,4...

Synonyms: AG-L-00192, NSC-648762, CTK7D3101, NSC648762, AC1L85TU, ...

Hong, S.B. et al., Kim, K.S. et al., Hong, S.B. et al., Kim, K.S. et al., Hong, S.B. et al.

Kim, Baek, Lee, Yang, Farrand,

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Disease relevance of agropine

Catabolic mannopine (MOP) cyclase encoded by certain Agrobacterium Ti and Ri plasmids lactonizes MOP to agropine (AGR) [1].

High impact information on agropine

NT1 harboring pYDH208 with an insertion mutation in mocC, which codes for MOP oxidoreductase, not only fails to utilize MOP as a sole carbon source, but also was inhibited in its growth by MOP and AGR [2].
To determine the requirement for MOP cyclase in opine catabolism unequivocally, a site-specific, nonpolar deletion mutation abolishing only MOP cyclase activity was introduced into pYDH208, a cosmid clone that confers utilization of MOP, AGR, and mannopinic acid (MOA) [3].

Biological context of agropine

MocR and MocS are related to each other and to a putative repressor for the AGR degradation system encoded by the rhizogenic plasmid pRiA4 [4].

Associations of agropine with other chemical compounds

Catabolic mannopine (MOP) cyclase encoded by Ti or Ri plasmids lactonizes MOP to agropine (AGR) [3].
We have isolated and characterized Tn3HoHo1- and Tn5-induced mutants of a cosmid clone, pYDH208, which encodes the mannopine (MOP) cyclase-associated catabolism of MOP and agropine (AGR) [5].

References

Purification and characterization of catabolic mannopine cyclase encoded by the Agrobacterium tumefaciens Ti plasmid pTi15955. Hong, S.B., Farrand, S.K. J. Bacteriol. (1996) [Pubmed]
Intracellular accumulation of mannopine, an opine produced by crown gall tumors, transiently inhibits growth of Agrobacterium tumefaciens. Kim, K.S., Baek, C.H., Lee, J.K., Yang, J.M., Farrand, S.K. Mol. Plant Microbe Interact. (2001) [Pubmed]
Functional role of the Ti plasmid-encoded catabolic mannopine cyclase in mannityl opine catabolism by Agrobacterium spp. Hong, S.B., Farrand, S.K. J. Bacteriol. (1994) [Pubmed]
Ti plasmid-encoded genes responsible for catabolism of the crown gall opine mannopine by Agrobacterium tumefaciens are homologs of the T-region genes responsible for synthesis of this opine by the plant tumor. Kim, K.S., Farrand, S.K. J. Bacteriol. (1996) [Pubmed]
Organization and regulation of the mannopine cyclase-associated opine catabolism genes in Agrobacterium tumefaciens 15955. Hong, S.B., Dessaux, Y., Chilton, W.S., Farrand, S.K. J. Bacteriol. (1993) [Pubmed]

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