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Chemical Compound Review:

Murrayafolin a 1-methoxy-3-methyl-9H- carbazole

Synonyms: CHEMBL490667, ANW-69013, NSC-654284, AK-54964, CTK8C2795, ...

Itoigawa, M. et al., Cuong, N.M. et al.

Cuong, Hung, Sung, Taylor,

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High impact information on NSC654284

A new dimeric pyranocarbazole alkaloid, bisisomahanine (1), was isolated from the roots of Glycosmis stenocarpa (DRAKE) TAN., along with two known monomeric carbazole alkaloids, murrayafoline-A (2) and murrayanine (3) [1].
Murrayaquinone A (1) and murrayafoline A (3), isolated from the root bark of Murraya euchrestifolia, were identified as cytotoxic compounds [2].
In contrast, murrayafoline A (3) exhibited marginal or weak cytotoxicity against SK-MEL-5, Colo-205, HCT-8, KB, and A-549 tumor cell lines, with ED(50) values ranging from 5.31 to 7.52 microg/mL [2].

References

A new dimeric carbazole alkaloid from Glycosmis stenocarpa roots. Cuong, N.M., Hung, T.Q., Sung, T.V., Taylor, W.C. Chem. Pharm. Bull. (2004) [Pubmed]
Antitumor agents. 203. Carbazole alkaloid murrayaquinone A and related synthetic carbazolequinones as cytotoxic agents. Itoigawa, M., Kashiwada, Y., Ito, C., Furukawa, H., Tachibana, Y., Bastow, K.F., Lee, K.H. J. Nat. Prod. (2000) [Pubmed]

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