Disease relevance of Rutaceae

• The present paper reports the results of the methanol extract of Haplophyllum hispanicum Spach on single or repeated local 12-O-tetradecanoylphorbol acetate (TPA) administration and in the oxazolone-induced contact-delayed hypersensitivity mouse ear edemas [1].

Psychiatry related information on Rutaceae

• Citronellyl acetate is considered to be the odor component most similar to kumquat by organoleptic evaluation with GC-O [2].

High impact information on Rutaceae

• Acridone alkaloids isolated from plants of the family Rutaceae have antiplasmodial activity in rodent models of malaria [3].
• Mahanine, a carbazole alkaloid from Micromelum minutum, inhibits cell growth and induces apoptosis in U937 cells through a mitochondrial dependent pathway [4].
• The results suggested that ACS divergently has evolved from CHS by very few amino acid exchanges, and it remains to be established why this route of functional diversity has developed in the Rutaceae only [5].
• Diphyllin isolated from Haplophyllum bucharicum Litv [6].
• A new acetophenone derivative, melicopone, along with twenty-nine known compounds has been isolated from the root wood of Melicope semecarpifolia [7].

Biological context of Rutaceae

• Mahanine, a carbazole alkaloid occurs in the edible part of Micromelum minutum, Murraya koenigii and related species has been found to induce apoptosis in human myeloid cancer cell (HL-60) [8].
• Oxidation of 2 with m-chloroperoxybenzoic acid followed by hydrolysis gave the racemic trans-(+)-1-(9,10-dihydro-9,10-dihydroxy-5-methoxy-2,2,8, 8-tetramethyl-2H,8H-benzo[1,2-b:3,4-b']dipyran-6-yl)ethanone (3), which confirmed the structure of the natural product previously isolated from Melicope erromangensis [9].

Associations of Rutaceae with chemical compounds

• Coumarins and carbazoles from Clausena excavata exhibited antimycobacterial and antifungal activities [10].
• Quinoline alkaloids and anti-platelet aggregation constituents from the leaves of Melicope semecarpifolia [11].
• Phellamurin is a flavonoid glycoside that is abundant in the leaves of Phellodendron wilsonii Hayata et Kanehira (Rutaceae) [12].
• Previous investigations have indicated that the pharmacological effects of evodiamine, a major alkaloidal component of the dried, unripe fruit of Evodia rutaecarpa Bentham (Rutaceae), are associated with stimulation of calcitonin gene-related peptide (CGRP) release and CGRP prevents cardiac anaphylactic injury [13].
• Four known coumarins, dentatin (1), nor-dentatin (2), clausenidin (3) and xanthoxyletin (5), and six known carbazole derivatives, 3-formylcarbazole (6), mukonal (7), 3-methoxycarbonylcarbazole (8), murrayanine (9), 2-hydroxy-3-formyl-7-methoxycarbazole (10) and clauszoline J (11) were isolated from Clausena excavata [10].

Gene context of Rutaceae

• Diphyllin acetylapioside, a 5-lipoxygenase inhibitor from Haplophyllum hispanicum [14].
• Antifungal and antioxidant compounds from the root bark of Fagara zanthoxyloides [15].
• Recently, the authors reported that evodiamine, a major alkaloidal principle of Evodia fruits (Evodia rutaecarpa, Rutaceae), had vanilloid receptor agonistic activity comparable to capsaicin [16].
• Wilson (Rutaceae) decreased the count of intestinal nematode eggs in naturally infected sheep [17].
• Evodiamine, a major alkaloidal principle of Evodia fruits (Evodia rutaecarpa, Rutaceae), showed vanilloid receptor agonistic activities comparable to capsaicin [18].

Analytical, diagnostic and therapeutic context of Rutaceae

• Twelve coumarins isolated from plants of the Rutaceae collected in Sri Lanka have been subjected to a mechanism-based anticancer bioassay employing DNA repair-deficient and repair-proficient yeasts [19].

References