The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review


Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Rutaceae

  • The present paper reports the results of the methanol extract of Haplophyllum hispanicum Spach on single or repeated local 12-O-tetradecanoylphorbol acetate (TPA) administration and in the oxazolone-induced contact-delayed hypersensitivity mouse ear edemas [1].

Psychiatry related information on Rutaceae


High impact information on Rutaceae

  • Acridone alkaloids isolated from plants of the family Rutaceae have antiplasmodial activity in rodent models of malaria [3].
  • Mahanine, a carbazole alkaloid from Micromelum minutum, inhibits cell growth and induces apoptosis in U937 cells through a mitochondrial dependent pathway [4].
  • The results suggested that ACS divergently has evolved from CHS by very few amino acid exchanges, and it remains to be established why this route of functional diversity has developed in the Rutaceae only [5].
  • Diphyllin isolated from Haplophyllum bucharicum Litv [6].
  • A new acetophenone derivative, melicopone, along with twenty-nine known compounds has been isolated from the root wood of Melicope semecarpifolia [7].

Biological context of Rutaceae

  • Mahanine, a carbazole alkaloid occurs in the edible part of Micromelum minutum, Murraya koenigii and related species has been found to induce apoptosis in human myeloid cancer cell (HL-60) [8].
  • Oxidation of 2 with m-chloroperoxybenzoic acid followed by hydrolysis gave the racemic trans-(+)-1-(9,10-dihydro-9,10-dihydroxy-5-methoxy-2,2,8, 8-tetramethyl-2H,8H-benzo[1,2-b:3,4-b']dipyran-6-yl)ethanone (3), which confirmed the structure of the natural product previously isolated from Melicope erromangensis [9].

Associations of Rutaceae with chemical compounds


Gene context of Rutaceae


Analytical, diagnostic and therapeutic context of Rutaceae

  • Twelve coumarins isolated from plants of the Rutaceae collected in Sri Lanka have been subjected to a mechanism-based anticancer bioassay employing DNA repair-deficient and repair-proficient yeasts [19].


  1. Topical anti-inflammatory lignans from Haplophyllum hispanicum. Prieto, J.M., Recio, M.C., Giner, R.M., Máñez, S., Massmanian, A., Waterman, P.G., Ríos, J.L. Z. Naturforsch., C, J. Biosci. (1996) [Pubmed]
  2. Characteristic odor components of kumquat (Fortunella japonica Swingle) peel oil. Choi, H.S. J. Agric. Food Chem. (2005) [Pubmed]
  3. In vitro activities of acridone alkaloids against Pneumocystis carinii. Queener, S.F., Fujioka, H., Nishiyama, Y., Furukawa, H., Bartlett, M.S., Smith, J.W. Antimicrob. Agents Chemother. (1991) [Pubmed]
  4. Mahanine, a carbazole alkaloid from Micromelum minutum, inhibits cell growth and induces apoptosis in U937 cells through a mitochondrial dependent pathway. Roy, M.K., Thalang, V.N., Trakoontivakorn, G., Nakahara, K. Br. J. Pharmacol. (2005) [Pubmed]
  5. Transformation of acridone synthase to chalcone synthase. Lukacin, R., Schreiner, S., Matern, U. FEBS Lett. (2001) [Pubmed]
  6. In vitro antileishmanial activity of diphyllin isolated from Haplophyllum bucharicum. Di Giorgio, C., Delmas, F., Akhmedjanova, V., Ollivier, E., Bessonova, I., Riad, E., Timon-David, P. Planta Med. (2005) [Pubmed]
  7. Cytotoxic and anti-platelet aggregation constituents from the root wood of Melicope semecarpifolia. Chou, H.C., Chen, J.J., Duh, C.Y., Huang, T.F., Chen, I.S. Planta Med. (2005) [Pubmed]
  8. Mechanism of mahanine-induced apoptosis in human leukemia cells (HL-60). Roy, M.K., Thalang, V.N., Trakoontivakorn, G., Nakahara, K. Biochem. Pharmacol. (2004) [Pubmed]
  9. Efficient synthesis of octandrenolone and related dipyranoacetophenones. Pernin, R., Muyard, F., Bévalot, F., Tillequin, F., Vaquette, J. J. Nat. Prod. (2000) [Pubmed]
  10. Coumarins and carbazoles from Clausena excavata exhibited antimycobacterial and antifungal activities. Sunthitikawinsakul, A., Kongkathip, N., Kongkathip, B., Phonnakhu, S., Daly, J.W., Spande, T.F., Nimit, Y., Rochanaruangrai, S. Planta Med. (2003) [Pubmed]
  11. Quinoline alkaloids and anti-platelet aggregation constituents from the leaves of Melicope semecarpifolia. Chen, J.J., Chang, Y.L., Teng, C.M., Su, C.C., Chen, I.S. Planta Med. (2002) [Pubmed]
  12. Marked decrease of cyclosporin absorption caused by phellamurin in rats. Chen, H.Y., Wu, T.S., Su, S.F., Kuo, S.C., Chao, P.D. Planta Med. (2002) [Pubmed]
  13. Protective effects of calcitonin gene-related peptide-mediated evodiamine on guinea-pig cardiac anaphylaxis. Rang, W.Q., Du, Y.H., Hu, C.P., Ye, F., Tan, G.S., Deng, H.W., Li, Y.J. Naunyn Schmiedebergs Arch. Pharmacol. (2003) [Pubmed]
  14. Diphyllin acetylapioside, a 5-lipoxygenase inhibitor from Haplophyllum hispanicum. Prieto, J.M., Giner, R.M., Recio Mf, M.C., Schinella, G., Máñez, S., Ríos, J.L. Planta Med. (2002) [Pubmed]
  15. Antifungal and antioxidant compounds from the root bark of Fagara zanthoxyloides. Chaaib, F., Queiroz, E.F., Ndjoko, K., Diallo, D., Hostettmann, K. Planta Med. (2003) [Pubmed]
  16. The nociceptive and anti-nociceptive effects of evodiamine from fruits of Evodia rutaecarpa in mice. Kobayashi, Y. Planta Med. (2003) [Pubmed]
  17. Anthelmintic properties of alpha-sanshool from Zanthoxylum liebmannianum. Navarrete, A., Hong, E. Planta Med. (1996) [Pubmed]
  18. Capsaicin-like anti-obese activities of evodiamine from fruits of Evodia rutaecarpa, a vanilloid receptor agonist. Kobayashi, Y., Nakano, Y., Kizaki, M., Hoshikuma, K., Yokoo, Y., Kamiya, T. Planta Med. (2001) [Pubmed]
  19. Biological activity of some coumarins from Sri Lankan Rutaceae. Gunatilaka, A.A., Kingston, D.G., Wijeratne, E.M., Bandara, B.M., Hofmann, G.A., Johnson, R.K. J. Nat. Prod. (1994) [Pubmed]
WikiGenes - Universities