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Chemical Compound Review:

CHEMBL396171 3-methyl-9H-carbazole-1,4- dione

Synonyms: SureCN5396418, NSC-654274, NSC654274, AC1L2S2V, NCI60_018838, ...

Takeya, K. et al., Itoigawa, M. et al.

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High impact information on Murrayachinon a

Triphasic inotropic response of guinea-pig papillary muscle to murrayaquinone-A isolated from Rutaceae [1].
Murrayaquinone-A increased the initial upstroke and the duration of the slow action potential in partially depolarized muscle (external K+ = 30 mEq) [1].

Biological context of Murrayachinon a

The structure-activity relationship of a novel natural substance murrayaquinone-A and related compounds, was studied by evaluating their positive inotropic potencies on guinea-pig papillary muscle in Krebs-Henseleit solution [2].

References

Triphasic inotropic response of guinea-pig papillary muscle to murrayaquinone-A isolated from Rutaceae. Takeya, K., Itoigawa, M., Furukawa, H. Eur. J. Pharmacol. (1989) [Pubmed]
Structure-activity relationship for the inotropic effect of aromatic methyl-p-quinones. Itoigawa, M., Takeya, K., Furukawa, H. Archives internationales de pharmacodynamie et de thérapie. (1990) [Pubmed]

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