Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Chemical Compound Review:

HDBA 5-[(2,5- dihydroxyphenyl)methylamino]- 2...

Synonyms: lavendustin c, Compound 5, CHEMBL319620, AG-J-49703, SureCN1821516, ...

Burt, H.M. et al., Zucchi, R. et al., Wang, Z. et al., Opałka, M. et al.

Opałka, Kamińska, Ciereszko, Dusza, Zucchi, Ghelardoni, Carnicelli, Frascarelli, Ronca, Ronca-Testoni,

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

High impact information on lavendustin c

Injection of either a specific CaMKII inhibitor peptide or lavendustin C, another CaMKII inhibitor, reduced Eag current amplitude acutely [1].
LVC strongly inhibited chemiluminescence, superoxide anion generation, myeloperoxidase and lysozyme release, and calcium mobilization [2].
After 1-min crystal-neutrophil incubations, neutrophil cytosolic fractions showed extensive inhibition of tyrosine kinase activity by LVC [2].
No significant effect of lavendustin C (inhibitor of PTK, a non-phytoestrogen) on the T production was observed [3].
Chelerythrine (protein kinase C inhibitor) and lavendustin C (Ca2+/calmodulin-dependent protein kinase II inhibitor), but not H-89 (protein kinase A inhibitor), abolished the effects of hypocalcemic perfusion on [3H]-PN 200-110 and [3H]-ryanodine binding [4].

References

Calcium/calmodulin-dependent protein kinase II phosphorylates and regulates the Drosophila eag potassium channel. Wang, Z., Wilson, G.F., Griffith, L.C. J. Biol. Chem. (2002) [Pubmed]
Inhibition of crystal-induced neutrophil activation by a protein tyrosine kinase inhibitor. Burt, H.M., Jackson, J.K., Salari, H. J. Leukoc. Biol. (1994) [Pubmed]
Genistein affects testosterone secretion by Leydig cells in roosters (Gallus gallus domesticus). Opałka, M., Kamińska, B., Ciereszko, R., Dusza, L. Reproductive biology. (2004) [Pubmed]
Ca2+ channel remodeling in perfused heart: Effects of mechanical work and interventions affecting Ca2+ cycling on sarcolemmal and sarcoplasmic reticulum Ca2+ channels. Zucchi, R., Ghelardoni, S., Carnicelli, V., Frascarelli, S., Ronca, F., Ronca-Testoni, S. FASEB J. (2002) [Pubmed]

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