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Chemical Compound Review:

Moniliformin 2-hydroxycyclobut-2-ene-1,4- dione

Synonyms: CCRIS 4943, AG-F-06393, AG-F-38803, NSC-292896, LS-91627, ...

Allen, N.K. et al., Burka, L.T. et al.

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Disease relevance of NSC 292896

Varying the hydroxycyclobutenedione structure by substitution or ring expansion resulted in loss of toxicity and inhibition [1].

High impact information on NSC 292896

Moniliformin (1-hydroxy-cyclobut-1-ene-3,4-dione), either purified (0, 8, and 16 mg/kg of diet) or from culture of Fusarium moniliforme strain NRRL 6322 on corn grits (8, 16, and 64 mg/kg of diet) was fed to growing broiler chicks from 1 to 21 days of age [2].

References

Enzyme inhibition and the toxic action of moniliformin and other vinylogous alpha-ketoacids. Burka, L.T., Doran, J., Wilson, B.J. Biochem. Pharmacol. (1982) [Pubmed]
Toxicity of dietary and intravenously administered moniliformin to broiler chickens. Allen, N.K., Burmeister, H.R., Weaver, G.A., Mirocha, C.J. Poult. Sci. (1981) [Pubmed]

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