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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
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Disease relevance of Fusarium


High impact information on Fusarium

  • Fusarium solani cutinase is a lipolytic enzyme with a catalytic serine accessible to solvent [6].
  • Fumonisins are sphinganine analogues produced by Fusarium moniliforme and related fungi [7].
  • The effects of methyl benzimidazole-2-ylcarbamate (MBC), one of only a few agents that are active against microtubules of fungi, were analyzed at the ultrastructural level in freeze-substituted hyphal tip cells of Fusarium acuminatum [8].
  • Furthermore, the jin1/myc2 and aba2-1 mutants showed increased resistance to the necrotrophic fungal pathogen Fusarium oxysporum [9].
  • Fumonisin B1 (FB1), a programmed cell death-eliciting toxin produced by the necrotrophic fungal plant pathogen Fusarium moniliforme, was used to simulate pathogen infection in Arabidopsis [10].

Chemical compound and disease context of Fusarium


Biological context of Fusarium


Anatomical context of Fusarium


Associations of Fusarium with chemical compounds

  • Trichothecenes, zearalenone, and other carcinogenic metabolites of Fusarium and related microfungi [26].
  • We propose that one or both of these leucine-rich repeats are involved in Fusarium wilt resistance with I2 specificity [27].
  • Here, we demonstrate that constitutive overexpression of this thionin enhances the resistance of the susceptible ecotype Columbia (Col-2) against attack by Fusarium oxysporum f sp matthiolae [28].
  • Infection patterns in barley and wheat spikes inoculated with wild-type and trichodiene synthase gene disrupted Fusarium graminearum [29].
  • The flavoprotein nitroalkane oxidase (NAO) from Fusarium oxysporum catalyzes the oxidation of nitroalkanes to the respective aldehydes with production of nitrite and hydrogen peroxide [30].

Gene context of Fusarium

  • Isolation and structure elucidation of Chlorofusin, a novel p53-MDM2 antagonist from a Fusarium sp [31].
  • ATAF2 overexpressing plants showed a higher susceptibility to the soil-borne fungal pathogen Fusarium oxysporum [32].
  • We have cloned a mitogen-activated protein kinase (MAPK) designated Fusarium solani f. sp. pisi mitogen-activated protein kinase (FsMAPK) from the phytopathogenic filamentous fungus F. solani f. sp. pisi T8 strain [33].
  • Role of chitin synthase genes in Fusarium oxysporum [34].
  • By using our original assay system, a fungal strain producing inhibitors for Pdr5p was obtained and classified as Fusarium sp. Y-53 [35].

Analytical, diagnostic and therapeutic context of Fusarium


  1. The tomato R gene products I-2 and MI-1 are functional ATP binding proteins with ATPase activity. Tameling, W.I., Elzinga, S.D., Darmin, P.S., Vossen, J.H., Takken, F.L., Haring, M.A., Cornelissen, B.J. Plant Cell (2002) [Pubmed]
  2. Toxicity and carcinogenicity of the Fusarium moniliforme metabolite, fumonisin B1, in rats. Gelderblom, W.C., Kriek, N.P., Marasas, W.F., Thiel, P.G. Carcinogenesis (1991) [Pubmed]
  3. Genotoxicity of zearalenone, an estrogenic mycotoxin: DNA adduct formation in female mouse tissues. Pfohl-Leszkowicz, A., Chekir-Ghedira, L., Bacha, H. Carcinogenesis (1995) [Pubmed]
  4. Defense responses of Fusarium oxysporum to 2,4-diacetylphloroglucinol, a broad-spectrum antibiotic produced by Pseudomonas fluorescens. Schouten, A., van den Berg, G., Edel-Hermann, V., Steinberg, C., Gautheron, N., Alabouvette, C., de Vos, C.H., Lemanceau, P., Raaijmakers, J.M. Mol. Plant Microbe Interact. (2004) [Pubmed]
  5. Comparative study on the natural occurrence of Fusarium mycotoxins (trichothecenes and zearalenone) in corn and wheat from high- and low-risk areas for human esophageal cancer in China. Luo, Y., Yoshizawa, T., Katayama, T. Appl. Environ. Microbiol. (1990) [Pubmed]
  6. Fusarium solani cutinase is a lipolytic enzyme with a catalytic serine accessible to solvent. Martinez, C., De Geus, P., Lauwereys, M., Matthyssens, G., Cambillau, C. Nature (1992) [Pubmed]
  7. Fumonisins: fungal toxins that shed light on sphingolipid function. Merrill, A.H., Liotta, D.C., Riley, R.T. Trends Cell Biol. (1996) [Pubmed]
  8. Cytoplasmic microtubules and fungal morphogenesis: ultrastructural effects of methyl benzimidazole-2-ylcarbamate determined by freeze-substitution of hyphal tip cells. Howard, R.J., Aist, J.R. J. Cell Biol. (1980) [Pubmed]
  9. Antagonistic interaction between abscisic acid and jasmonate-ethylene signaling pathways modulates defense gene expression and disease resistance in Arabidopsis. Anderson, J.P., Badruzsaufari, E., Schenk, P.M., Manners, J.M., Desmond, O.J., Ehlert, C., Maclean, D.J., Ebert, P.R., Kazan, K. Plant Cell (2004) [Pubmed]
  10. Simulation of fungal-mediated cell death by fumonisin B1 and selection of fumonisin B1-resistant (fbr) Arabidopsis mutants. Stone, J.M., Heard, J.E., Asai, T., Ausubel, F.M. Plant Cell (2000) [Pubmed]
  11. Role of chemotaxis toward fusaric acid in colonization of hyphae of Fusarium oxysporum f. sp. radicis-lycopersici by Pseudomonas fluorescens WCS365. de Weert, S., Kuiper, I., Lagendijk, E.L., Lamers, G.E., Lugtenberg, B.J. Mol. Plant Microbe Interact. (2004) [Pubmed]
  12. The GUS gene fusion system (Escherichia coli beta-D-glucuronidase gene), a useful tool in studies of root colonization by Fusarium oxysporum. Couteaudier, Y., Daboussi, M.J., Eparvier, A., Langin, T., Orcival, J. Appl. Environ. Microbiol. (1993) [Pubmed]
  13. Natural occurrence of the mycotoxin fusarochromanone, a metabolite of Fusarium equiseti, in cereal feed associated with tibial dyschondroplasia. Krogh, P., Christensen, D.H., Hald, B., Harlou, B., Larsen, C., Pedersen, E.J., Thrane, U. Appl. Environ. Microbiol. (1989) [Pubmed]
  14. Binding rather than metabolism may explain the interaction of two food-Grade Lactobacillus strains with zearalenone and its derivative (')alpha-earalenol. El-Nezami, H., Polychronaki, N., Salminen, S., Mykkänen, H. Appl. Environ. Microbiol. (2002) [Pubmed]
  15. Solubilization and refolding of inclusion body proteins in reverse micelles. Vinogradov, A.A., Kudryashova, E.V., Levashov, A.V., van Dongen, W.M. Anal. Biochem. (2003) [Pubmed]
  16. Nucleotide sequence of the unique nitrate/nitrite-inducible cytochrome P-450 cDNA from Fusarium oxysporum. Kizawa, H., Tomura, D., Oda, M., Fukamizu, A., Hoshino, T., Gotoh, O., Yasui, T., Shoun, H. J. Biol. Chem. (1991) [Pubmed]
  17. Frp1 is a Fusarium oxysporum F-box protein required for pathogenicity on tomato. Duyvesteijn, R.G., van Wijk, R., Boer, Y., Rep, M., Cornelissen, B.J., Haring, M.A. Mol. Microbiol. (2005) [Pubmed]
  18. RESISTANCE TO FUSARIUM OXYSPORUM 1, a dominant Arabidopsis disease-resistance gene, is not race specific. Diener, A.C., Ausubel, F.M. Genetics (2005) [Pubmed]
  19. Identification of intermediate and branch metabolites resulting from biotransformation of 2-benzoxazolinone by Fusarium verticillioides. Glenn, A.E., Meredith, F.I., Morrison, W.H., Bacon, C.W. Appl. Environ. Microbiol. (2003) [Pubmed]
  20. Cloning of a novel constitutively expressed pectate lyase gene pelB from Fusarium solani f. sp. pisi (Nectria haematococca, mating type VI) and characterization of the gene product expressed in Pichia pastoris. Guo, W., González-Candelas, L., Kolattukudy, P.E. J. Bacteriol. (1995) [Pubmed]
  21. The cancer-initiating potential of the fumonisin B mycotoxins. Gelderblom, W.C., Semple, E., Marasas, W.F., Farber, E. Carcinogenesis (1992) [Pubmed]
  22. Immunosuppression affects the severity of experimental Fusarium solani keratitis. Wu, T.G., Keasler, V.V., Mitchell, B.M., Wilhelmus, K.R. J. Infect. Dis. (2004) [Pubmed]
  23. In vitro studies of activity of voriconazole (UK-109,496), a new triazole antifungal agent, against emerging and less-common mold pathogens. Radford, S.A., Johnson, E.M., Warnock, D.W. Antimicrob. Agents Chemother. (1997) [Pubmed]
  24. Hydrolysis of plant cuticle by plant pathogens. Purification, amino acid composition, and molecular weight of two isozymes of cutinase and a nonspecific esterase from Fusarium solani f. pisi. Purdy, R.E., Kolattukudy, P.E. Biochemistry (1975) [Pubmed]
  25. Toxicity of some Fusarium section Sporotrichiella strains in relation to mycotoxin production. Visconti, A., Minervini, F., Solfrizzo, M., Bottalico, C., Lucivero, G. Appl. Environ. Microbiol. (1992) [Pubmed]
  26. Trichothecenes, zearalenone, and other carcinogenic metabolites of Fusarium and related microfungi. Schoental, R. Adv. Cancer Res. (1985) [Pubmed]
  27. Dissection of the fusarium I2 gene cluster in tomato reveals six homologs and one active gene copy. Simons, G., Groenendijk, J., Wijbrandi, J., Reijans, M., Groenen, J., Diergaarde, P., Van der Lee, T., Bleeker, M., Onstenk, J., de Both, M., Haring, M., Mes, J., Cornelissen, B., Zabeau, M., Vos, P. Plant Cell (1998) [Pubmed]
  28. Overexpression of an endogenous thionin enhances resistance of Arabidopsis against Fusarium oxysporum. Epple, P., Apel, K., Bohlmann, H. Plant Cell (1997) [Pubmed]
  29. Infection patterns in barley and wheat spikes inoculated with wild-type and trichodiene synthase gene disrupted Fusarium graminearum. Jansen, C., von Wettstein, D., Schäfer, W., Kogel, K.H., Felk, A., Maier, F.J. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  30. Cloning of nitroalkane oxidase from Fusarium oxysporum identifies a new member of the acyl-CoA dehydrogenase superfamily. Daubner, S.C., Gadda, G., Valley, M.P., Fitzpatrick, P.F. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  31. Isolation and structure elucidation of Chlorofusin, a novel p53-MDM2 antagonist from a Fusarium sp. Duncan, S.J., Grüschow, S., Williams, D.H., McNicholas, C., Purewal, R., Hajek, M., Gerlitz, M., Martin, S., Wrigley, S.K., Moore, M. J. Am. Chem. Soc. (2001) [Pubmed]
  32. The transcription factor ATAF2 represses the expression of pathogenesis-related genes in Arabidopsis. Delessert, C., Kazan, K., Wilson, I.W., Van Der Straeten, D., Manners, J., Dennis, E.S., Dolferus, R. Plant J. (2005) [Pubmed]
  33. Cloning and expression of cDNA encoding a mitogen-activated protein kinase from a phytopathogenic filamentous fungus. Li, D., Rogers, L., Kolattukudy, P.E. Gene (1997) [Pubmed]
  34. Role of chitin synthase genes in Fusarium oxysporum. Martín-Udíroz, M., Madrid, M.P., Roncero, M.I. Microbiology (Reading, Engl.) (2004) [Pubmed]
  35. Enniatin has a new function as an inhibitor of Pdr5p, one of the ABC transporters in Saccharomyces cerevisiae. Hiraga, K., Yamamoto, S., Fukuda, H., Hamanaka, N., Oda, K. Biochem. Biophys. Res. Commun. (2005) [Pubmed]
  36. Role of lysine, tryptophan and calcium in the beta-elimination activity of a low-molecular-mass pectate lyase from Fusarium moniliformae. Rao, M.N., Kembhavi, A.A., Pant, A. Biochem. J. (1996) [Pubmed]
  37. Elaboration of vomitoxin and zearalenone by Fusarium isolates and the biological activity of Fusarium-produced toxins. Vesonder, R.F., Ellis, J.J., Rohwedder, W.K. Appl. Environ. Microbiol. (1981) [Pubmed]
  38. Rapid and sensitive determination of zearalenone in cereals by high-performance liquid chromatography with fluorescence detection. Tanaka, T., Hasegawa, A., Matsuki, Y., Lee, U.S., Ueno, Y. J. Chromatogr. (1985) [Pubmed]
  39. Purification and characterization of the sesquiterpene cyclase trichodiene synthetase from Fusarium sporotrichioides. Hohn, T.M., Vanmiddlesworth, F. Arch. Biochem. Biophys. (1986) [Pubmed]
  40. Determination of the Fusarium mycotoxin beauvericin at micrograms/kg levels in corn by high-performance liquid chromatography with diode-array detection. Krska, R., Schuhmacher, R., Grasserbauer, M., Scott, P.M. Journal of chromatography. A. (1996) [Pubmed]
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