Disease relevance of NSC 292896

• Twenty strains of each of these biological species were tested for the ability to produce fumonisins B1, B2, and B3 and moniliformin and for toxicity to 1-day-old ducklings [1].
• For 1-day-old chicks dosed with moniliformin by crop intubation and for female and male mice injected intraperitoneally, the 50% lethal doses were 5.4, 20.9, and 29.1 mg per kg of body weight, respectively [2].
• Chicks fed 64 mg moniliformin/kg of diet from culture had reduced weight gain and feed consumption [3].
• Moniliformin caused a bradycardia, which became highly significant (P < 0.05) within 15 minutes post-injection [4].
• A sudden death syndrome induced in poults and chicks fed diets containing Fusarium fujikuroi with known concentrations of moniliformin [5].

High impact information on NSC 292896

• Rat brain transketolase and pyruvate dehydrogenase were inhibited 25 percent by 10-9 M moniliformin [6].
• The moniliformin was extracted from the grits with methanol, purified by preparative thin-layer chromatography, and crystallized from ether [2].
• The derivatization reaction of the mycotoxin moniliformin with 1,2-diamino-4,5-dichlorobenzene was previously introduced to improve distinctly the sensitivity of an assay applying high-performance liquid chromatography prior to fluorescence detection [7].
• Mass spectrometric detection of moniliformin was accomplished following atmospheric pressure chemical ionization to yield the deprotonated molecular ion [M-H]- at m/z 97 [8].
• Five South African strains of Fusarium subglutinans were grown on maize kernels and moniliformin extracted with an acetonitrile-water (95:5) mixture [8].

Chemical compound and disease context of NSC 292896

• This correlation of moniliformin concentration and noncorrelation of fumonisin B1 concentrations to acute toxicity were confirmed by duckling assay using diets containing these purified mycotoxins [9].
• However, moniliformin-induced hypoxia or altered function of cardiac pyruvate dehydrogenase, rather than direct cardiostimulation have been proposed as potential mechanisms [10].
• Toxicity of trichothecenes, moniliformin, zearalenone/ol, griseofulvin, patulin, PR toxin and rubratoxin B on protozoan tetrahymena pyriformis [11].

Biological context of NSC 292896

• The LD50 of purified moniliformin upon intravenous injection of 7-week-old female broiler chickens was 1.38 +/- .035 mg/kg body weight [3].
• The degrees of inhibition of gluconeogenesis by the two anhydro sugars and moniliformin were greater than their effect on cell viability [12].
• Four Fusarium metabolites, 2,5-anhydro-D-mannitol, 2,5-anhydro-D-sorbitol, moniliformin, and fumonisin B1, were tested for their ability to inhibit gluconeogenesis and cell viability in a primary chicken embryo hepatocyte culture system [12].
• Here, it was determined whether the two groups differ in the agriculturally important traits of virulence on maize and moniliformin production in planta [13].
• Overall, the amounts of moniliformin detected in extruded corn grits increased significantly by using enzyme hydrolysis [14].

Anatomical context of NSC 292896

• Genotoxic effects of three Fusarium mycotoxins, fumonisin B1, moniliformin and vomitoxin in bacteria and in primary cultures of rat hepatocytes [15].
• Fusaric acid was cytotoxic to the MDCK, MM, RH, and CHO cell lines; moniliformin was cytotoxic to the RH, CHO, and MDCK, cell lines [16].
• Intragastric intubation of moniliformin caused hemorrhage of the small intestine and death in 5 of 5 rats at each concentration of 100, 80, 60 and 40 mg/kg body weight and death of 4 of 5 rats at 20 mg/kg [17].
• Ultrastructural study of moniliformin induced lesions of myocardium in rats and mice [18].
• L6 myoblasts were a useful model of moniliformin toxicosis [19].

Associations of NSC 292896 with other chemical compounds

• The Fusarium mycotoxin moniliformin (hydroxycyclobutenedione) has been determined in maize using a novel method with a recovery of 70-80% at 400-1600 micrograms/kg and 60% at the detection limit of 100 micrograms/kg [20].
• The ability to produce moniliformin seems to be an ancestral feature of members of the genus Fusarium which seems to have been lost in the clades consisting of trichothecene/zearalenone producers [21].
• We also report the sensitivity of maize to other Gibberella toxins - beauvericin, diacetoxyscirpenol, and moniliformin [22].
• Electrocardiography was used to examine the acute cardiotoxic effects of moniliformin on 3-week-old broiler chickens [4].
• In this study mammalian cell cultures were used to screen the cytotoxicity of the most common Fusarium mycotoxins; deoxynivalenol (DON), zearalenone (ZEN), fumonisin B(1) (FB(1)) and moniliformin (MON) [23].

Gene context of NSC 292896

• A study on the inhibition of rat myocardium glutathione peroxidase and glutathione reductase by moniliformin [24].
• Poults fed FB1 had moderate diffuse hepatocellular hyperplasia and poults fed moniliformin had a loss of cardiomyocyte cross striations [25].
• Maize Ear Rot and Moniliformin Contamination by Cryptic Species of Fusarium subglutinans [13].
• Methods used previously for the determination of aflatoxins B1, B2, G1 and G2, ochratoxins A and B, cyclopiazonic acid, zearalenone, sterigmatocystin, and moniliformin in maize were applied successfully to rice bran [26].

Analytical, diagnostic and therapeutic context of NSC 292896

• Method for the analysis in maize of the Fusarium mycotoxin moniliformin employing ion-pairing extraction and high-performance liquid chromatography [20].
• DNA microarray to detect and identify trichothecene- and moniliformin-producing Fusarium species [27].
• Acute cardiotoxicity of moniliformin in broiler chickens as measured by electrocardiography [4].
• Testing for MON commonly involves extraction of maize, isolation of moniliformin using solid-phase extraction columns and detection with high-performance liquid chromatography (HPLC) or gas chromatography [28].
• Chemical analysis (by HPLC) revealed that the tested cultivars were contaminated with deoxynivalenol (96% of investigated samples), its acetyl derivatives (48%), nivalenol (76%) and moniliformin (28%) [29].

References