Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Chemical Compound Review:

AG-G-22679 5-hydroxy-1-methyl-5-pyridin- 3-yl...

Synonyms: SureCN11098477, CTK5B2824, AC1L196J, 61192-50-5

von Weymarn, L.B. et al., Rincón, J. et al.

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High impact information on allohydroxycotinine

CYP2A13 catalyzed this reaction as well as further metabolism of cotinine to 5'-hydroxycotinine, trans-3'-hydroxycotinine, and N-(hydroxymethyl)-norcotinine as enzyme inactivation occurred [1].
Effect of the nicotine metabolite 5'-hydroxycotinine on glucose transport and glycogen synthase activity in rat skeletal muscle [2].

References

Inactivation of CYP2A6 and CYP2A13 during nicotine metabolism. von Weymarn, L.B., Brown, K.M., Murphy, S.E. J. Pharmacol. Exp. Ther. (2006) [Pubmed]
Effect of the nicotine metabolite 5'-hydroxycotinine on glucose transport and glycogen synthase activity in rat skeletal muscle. Rincón, J., Galuska, D., Ryder, J.W., Kawano, Y., Wallberg-Henriksson, H., Gorrod, J.W., Zierath, J.R. Pflugers Arch. (1999) [Pubmed]

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