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Chemical Compound Review

rac-Cotinine     1-methyl-5-pyridin-3-yl- pyrrolidin-2-one

Synonyms: CHEMBL664, rac Cotinine, S-(-)-Cotinine, Cotinine [INN], SureCN49061, ...
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Disease relevance of cotinine


Psychiatry related information on cotinine


High impact information on cotinine


Chemical compound and disease context of cotinine


Biological context of cotinine


Anatomical context of cotinine


Associations of cotinine with other chemical compounds


Gene context of cotinine


Analytical, diagnostic and therapeutic context of cotinine


  1. Cocaine and tobacco use and the risk of spontaneous abortion. Ness, R.B., Grisso, J.A., Hirschinger, N., Markovic, N., Shaw, L.M., Day, N.L., Kline, J. N. Engl. J. Med. (1999) [Pubmed]
  2. Human papillomavirus infection as a risk factor for squamous-cell carcinoma of the head and neck. Mork, J., Lie, A.K., Glattre, E., Hallmans, G., Jellum, E., Koskela, P., Møller, B., Pukkala, E., Schiller, J.T., Youngman, L., Lehtinen, M., Dillner, J. N. Engl. J. Med. (2001) [Pubmed]
  3. The impact on infant birth weight and gestational age of cotinine-validated smoking reduction during pregnancy. Li, C.Q., Windsor, R.A., Perkins, L., Goldenberg, R.L., Lowe, J.B. JAMA (1993) [Pubmed]
  4. Association of pediatric dental caries with passive smoking. Aligne, C.A., Moss, M.E., Auinger, P., Weitzman, M. JAMA (2003) [Pubmed]
  5. Nicotine, cotinine, and anabasine inhibit aromatase in human trophoblast in vitro. Barbieri, R.L., Gochberg, J., Ryan, K.J. J. Clin. Invest. (1986) [Pubmed]
  6. A randomized trial of a family physician intervention for smoking cessation. Wilson, D.M., Taylor, D.W., Gilbert, J.R., Best, J.A., Lindsay, E.A., Willms, D.G., Singer, J. JAMA (1988) [Pubmed]
  7. High-dose nicotine patch therapy. Percentage of replacement and smoking cessation. Dale, L.C., Hurt, R.D., Offord, K.P., Lawson, G.M., Croghan, I.T., Schroeder, D.R. JAMA (1995) [Pubmed]
  8. Alcohol consumption, Lewis phenotypes, and risk of ischaemic heart disease. Hein, H.O., Sørensen, H., Suadicani, P., Gyntelberg, F. Lancet (1993) [Pubmed]
  9. Blood cotinine levels as indicators of smoking treatment outcome. Hall, S.M., Herning, R.I., Jones, R.T., Benowitz, N.L., Jacob, P. Clin. Pharmacol. Ther. (1984) [Pubmed]
  10. No excess risk of cervical carcinoma among women seropositive for both HPV16 and HPV6/11. Luostarinen, T., af Geijersstam, V., Bjørge, T., Eklund, C., Hakama, M., Hakulinen, T., Jellum, E., Koskela, P., Paavonen, J., Pukkala, E., Schiller, J.T., Thoresen, S., Youngman, L.D., Dillner, J., Lehtinen, M. Int. J. Cancer (1999) [Pubmed]
  11. Serotypes of Chlamydia trachomatis and risk for development of cervical squamous cell carcinoma. Anttila, T., Saikku, P., Koskela, P., Bloigu, A., Dillner, J., Ikäheimo, I., Jellum, E., Lehtinen, M., Lenner, P., Hakulinen, T., Närvänen, A., Pukkala, E., Thoresen, S., Youngman, L., Paavonen, J. JAMA (2001) [Pubmed]
  12. Exposure of the US population to environmental tobacco smoke: the Third National Health and Nutrition Examination Survey, 1988 to 1991. Pirkle, J.L., Flegal, K.M., Bernert, J.T., Brody, D.J., Etzel, R.A., Maurer, K.R. JAMA (1996) [Pubmed]
  13. Smokeless tobacco use and health effects among baseball players. Ernster, V.L., Grady, D.G., Greene, J.C., Walsh, M., Robertson, P., Daniels, T.E., Benowitz, N., Siegel, D., Gerbert, B., Hauck, W.W. JAMA (1990) [Pubmed]
  14. Nicotine patch therapy for smoking cessation combined with physician advice and nurse follow-up. One-year outcome and percentage of nicotine replacement. Hurt, R.D., Dale, L.C., Fredrickson, P.A., Caldwell, C.C., Lee, G.A., Offord, K.P., Lauger, G.G., Marŭsić, Z., Neese, L.W., Lundberg, T.G. JAMA (1994) [Pubmed]
  15. A randomized trial of nortriptyline for smoking cessation. Prochazka, A.V., Weaver, M.J., Keller, R.T., Fryer, G.E., Licari, P.A., Lofaso, D. Arch. Intern. Med. (1998) [Pubmed]
  16. Effect of caffeine exposure during pregnancy on birth weight and gestational age. Clausson, B., Granath, F., Ekbom, A., Lundgren, S., Nordmark, A., Signorello, L.B., Cnattingius, S. Am. J. Epidemiol. (2002) [Pubmed]
  17. Serum selenium concentration and risk of ischaemic heart disease in a prospective cohort study of 3000 males. Suadicani, P., Hein, H.O., Gyntelberg, F. Atherosclerosis (1992) [Pubmed]
  18. Nicotine, cotinine, and trans-3-hydroxycotinine levels in seminal plasma of smokers: effects on sperm parameters. Pacifici, R., Altieri, I., Gandini, L., Lenzi, A., Pichini, S., Rosa, M., Zuccaro, P., Dondero, F. Therapeutic drug monitoring. (1993) [Pubmed]
  19. Identification of tobacco-specific carcinogen in the cervical mucus of smokers and nonsmokers. Prokopczyk, B., Cox, J.E., Hoffmann, D., Waggoner, S.E. J. Natl. Cancer Inst. (1997) [Pubmed]
  20. Cotinine disposition and effects. Benowitz, N.L., Kuyt, F., Jacob, P., Jones, R.T., Osman, A.L. Clin. Pharmacol. Ther. (1983) [Pubmed]
  21. Duplications and defects in the CYP2A6 gene: identification, genotyping, and in vivo effects on smoking. Rao, Y., Hoffmann, E., Zia, M., Bodin, L., Zeman, M., Sellers, E.M., Tyndale, R.F. Mol. Pharmacol. (2000) [Pubmed]
  22. Nicotine and cotinine elimination pharmacokinetics in smokers and nonsmokers. Benowitz, N.L., Jacob, P. Clin. Pharmacol. Ther. (1993) [Pubmed]
  23. Fibrinogen as a risk factor for coronary heart disease and mortality in middle-aged men and women. The Scottish Heart Health Study. Woodward, M., Lowe, G.D., Rumley, A., Tunstall-Pedoe, H. Eur. Heart J. (1998) [Pubmed]
  24. Cotinine in amniotic fluids from passive smokers. Andresen, B.D., Ng, K.J., Iams, J.D., Bianchine, J.R. Lancet (1982) [Pubmed]
  25. Smoking and decreased fertilisation rates in vitro. Rosevear, S.K., Holt, D.W., Lee, T.D., Ford, W.C., Wardle, P.G., Hull, M.G. Lancet (1992) [Pubmed]
  26. 2'-Hydroxylation of nicotine by cytochrome P450 2A6 and human liver microsomes: formation of a lung carcinogen precursor. Hecht, S.S., Hochalter, J.B., Villalta, P.W., Murphy, S.E. Proc. Natl. Acad. Sci. U.S.A. (2000) [Pubmed]
  27. Correlation between nicotine-induced inhibition of hematopoiesis and decreased CD44 expression on bone marrow stromal cells. Khaldoyanidi, S., Sikora, L., Orlovskaya, I., Matrosova, V., Kozlov, V., Sriramarao, P. Blood (2001) [Pubmed]
  28. Determinants of polycyclic aromatic hydrocarbon-DNA adducts in human placenta. Manchester, D.K., Bowman, E.D., Parker, N.B., Caporaso, N.E., Weston, A. Cancer Res. (1992) [Pubmed]
  29. Evaluation of the effects of cotinine and nicotine-N'-oxides on the development of tumors in rats initiated with N-[4-(5-nitro-2-furyl)-2-thiazolyl]formamide. LaVoie, E.J., Shigematsu, A., Rivenson, A., Mu, B., Hoffmann, D. J. Natl. Cancer Inst. (1985) [Pubmed]
  30. Measurement of 4-aminobiphenyl-hemoglobin adducts in lung cancer cases and controls. Weston, A., Caporaso, N.E., Taghizadeh, K., Hoover, R.N., Tannenbaum, S.R., Skipper, P.L., Resau, J.H., Trump, B.F., Harris, C.C. Cancer Res. (1991) [Pubmed]
  31. Dose-related cardiovascular and endocrine effects of transdermal nicotine. Zevin, S., Jacob, P., Benowitz, N.L. Clin. Pharmacol. Ther. (1998) [Pubmed]
  32. Immune function in cigarette smokers who quit smoking for 31 days. Meliska, C.J., Stunkard, M.E., Gilbert, D.G., Jensen, R.A., Martinko, J.M. J. Allergy Clin. Immunol. (1995) [Pubmed]
  33. In vitro-in vivo correlations of human (S)-nicotine metabolism. Berkman, C.E., Park, S.B., Wrighton, S.A., Cashman, J.R. Biochem. Pharmacol. (1995) [Pubmed]
  34. Individual differences in urinary cotinine levels in Japanese smokers: relation to genetic polymorphism of drug-metabolizing enzymes. Yang, M., Kunugita, N., Kitagawa, K., Kang, S.H., Coles, B., Kadlubar, F.F., Katoh, T., Matsuno, K., Kawamoto, T. Cancer Epidemiol. Biomarkers Prev. (2001) [Pubmed]
  35. Nicotine and cotinine stimulate secretion of basic fibroblast growth factor and affect expression of matrix metalloproteinases in cultured human smooth muscle cells. Carty, C.S., Soloway, P.D., Kayastha, S., Bauer, J., Marsan, B., Ricotta, J.J., Dryjski, M. J. Vasc. Surg. (1996) [Pubmed]
  36. Evaluation of methoxsalen, tranylcypromine, and tryptamine as specific and selective CYP2A6 inhibitors in vitro. Zhang, W., Kilicarslan, T., Tyndale, R.F., Sellers, E.M. Drug Metab. Dispos. (2001) [Pubmed]
  37. Racial and ethnic differences in serum cotinine levels of cigarette smokers: Third National Health and Nutrition Examination Survey, 1988-1991. Caraballo, R.S., Giovino, G.A., Pechacek, T.F., Mowery, P.D., Richter, P.A., Strauss, W.J., Sharp, D.J., Eriksen, M.P., Pirkle, J.L., Maurer, K.R. JAMA (1998) [Pubmed]
  38. Biomarkers of environmental tobacco smoke in preschool children and their mothers. Crawford, F.G., Mayer, J., Santella, R.M., Cooper, T.B., Ottman, R., Tsai, W.Y., Simon-Cereijido, G., Wang, M., Tang, D., Perera, F.P. J. Natl. Cancer Inst. (1994) [Pubmed]
  39. Effect of smoking cessation on cervical lesion size. Szarewski, A., Jarvis, M.J., Sasieni, P., Anderson, M., Edwards, R., Steele, S.J., Guillebaud, J., Cuzick, J. Lancet (1996) [Pubmed]
  40. Transdermal nicotine for mildly to moderately active ulcerative colitis. A randomized, double-blind, placebo-controlled trial. Sandborn, W.J., Tremaine, W.J., Offord, K.P., Lawson, G.M., Petersen, B.T., Batts, K.P., Croghan, I.T., Dale, L.C., Schroeder, D.R., Hurt, R.D. Ann. Intern. Med. (1997) [Pubmed]
  41. Inverse relation between serum cotinine concentration and blood pressure in cigarette smokers. Benowitz, N.L., Sharp, D.S. Circulation (1989) [Pubmed]
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