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Chemical Compound Review

AGN-PC-0061CM     3-hydroxy-1-methyl-5-pyridin- 3-yl...

Synonyms: CCRIS 7628, AG-F-19547, AG-J-02884, SureCN4538005, CTK5E6936, ...
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Psychiatry related information on CCRIS 7628

  • Plasma ratios of trans-3'-hydroxycotinine (3HC) to cotinine (COT) were examined in 92 cessation treatment-seeking adolescents (mean age 15.2 years, standard deviation [SD] 1.3, 69% female, 31% African American, mean Fagerström Test for Nicotine Dependence [FTND] 6.5, SD 1.6, mean years smoked 2.6, SD 1.6) [1].

High impact information on CCRIS 7628


Biological context of CCRIS 7628


Anatomical context of CCRIS 7628


Associations of CCRIS 7628 with other chemical compounds


Gene context of CCRIS 7628


Analytical, diagnostic and therapeutic context of CCRIS 7628


  1. Adolescent nicotine metabolism: ethnoracial differences among dependent smokers. Moolchan, E.T., Franken, F.H., Jaszyna-Gasior, M. Ethnicity & disease. (2006) [Pubmed]
  2. Nicotine metabolite ratio as an index of cytochrome P450 2A6 metabolic activity. Dempsey, D., Tutka, P., Jacob, P., Allen, F., Schoedel, K., Tyndale, R.F., Benowitz, N.L. Clin. Pharmacol. Ther. (2004) [Pubmed]
  3. N-glucuronidation of trans-3'-hydroxycotinine by human liver microsomes. Kuehl, G.E., Murphy, S.E. Chem. Res. Toxicol. (2003) [Pubmed]
  4. Nicotine metabolism and CYP2D6 phenotype in smokers. Caporaso, N.E., Lerman, C., Audrain, J., Boyd, N.R., Main, D., Issaq, H.J., Utermahlan, B., Falk, R.T., Shields, P. Cancer Epidemiol. Biomarkers Prev. (2001) [Pubmed]
  5. Characterization of CYP2A6 involved in 3'-hydroxylation of cotinine in human liver microsomes. Nakajima, M., Yamamoto, T., Nunoya, K., Yokoi, T., Nagashima, K., Inoue, K., Funae, Y., Shimada, N., Kamataki, T., Kuroiwa, Y. J. Pharmacol. Exp. Ther. (1996) [Pubmed]
  6. Synthesis of a hapten to be used in development of immunoassays for trans-3'-hydroxycotinine, a major metabolite of cotinine. Desai, D.H., Amin, S. Chem. Res. Toxicol. (1991) [Pubmed]
  7. Determination of nicotine and its main metabolites in urine by high-performance liquid chromatography. Rop, P.P., Grimaldi, F., Oddoze, C., Viala, A. J. Chromatogr. (1993) [Pubmed]
  8. Sources of variability in nicotine and cotinine levels with use of nicotine nasal spray, transdermal nicotine, and cigarette smoking. Benowitz, N.L., Zevin, S., Jacob, P. British journal of clinical pharmacology. (1997) [Pubmed]
  9. Nicotine, cotinine, and trans-3-hydroxycotinine levels in seminal plasma of smokers: effects on sperm parameters. Pacifici, R., Altieri, I., Gandini, L., Lenzi, A., Pichini, S., Rosa, M., Zuccaro, P., Dondero, F. Therapeutic drug monitoring. (1993) [Pubmed]
  10. Nicotine metabolism in healthy smokers and patients with cardiovascular diseases. Chahine, R., Abchee, A., Zalloua, P. Mol. Cell. Biochem. (2005) [Pubmed]
  11. Pharmacokinetics of nicotine, cotinine, and 3'-hydroxycotinine in cigarette smokers. Scherer, G., Jarczyk, L., Heller, W.D., Biber, A., Neurath, G.B., Adlkofer, F. Klin. Wochenschr. (1988) [Pubmed]
  12. Trans-3'-hydroxycotinine O- and N-glucuronidations in human liver microsomes. Yamanaka, H., Nakajima, M., Katoh, M., Kanoh, A., Tamura, O., Ishibashi, H., Yokoi, T. Drug Metab. Dispos. (2005) [Pubmed]
  13. A validated method for the determination of nicotine, cotinine, trans-3'-hydroxycotinine, and norcotinine in human plasma using solid-phase extraction and liquid chromatography-atmospheric pressure chemical ionization-mass spectrometry. Kim, I., Huestis, M.A. Journal of mass spectrometry : JMS. (2006) [Pubmed]
  14. Metabolism of nicotine and cotinine by human cytochrome P450 2A13. Bao, Z., He, X.Y., Ding, X., Prabhu, S., Hong, J.Y. Drug Metab. Dispos. (2005) [Pubmed]
  15. Determination of the nicotine metabolite trans-3'-hydroxycotinine in urine of smokers using gas chromatography with nitrogen-selective detection or selected ion monitoring. Jacob, P., Shulgin, A.T., Yu, L., Benowitz, N.L. J. Chromatogr. (1992) [Pubmed]
  16. Passive smoke exposure in infants and children with respiratory tract diseases. Köhler, E., Sollich, V., Schuster, R., Thal, W. Human & experimental toxicology. (1999) [Pubmed]
  17. Assessment of prenatal smoke exposure by determining nicotine and its metabolites in maternal and neonatal urine. Köhler, E., Bretschneider, D., Rabsilber, A., Weise, W., Jorch, G. Human & experimental toxicology. (2001) [Pubmed]
  18. Trans-3'-hydroxycotinine--a main metabolite in smokers. Neurath, G.B., Dünger, M., Krenz, O., Orth, D., Pein, F.G. Klin. Wochenschr. (1988) [Pubmed]
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