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Chemical Compound Review:

Prosapogenin bis[3,4,5-trihydroxy-6- (hydroxymethyl)oxan...

Synonyms: NSC-124670, AC1L9JTZ, NSC124670, ro-pyran-2-yl) ester

Chiang, H.C. et al., Kirmizigül, S. et al., Oh, S.R. et al., Zheng, Q. et al.

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Disease relevance of AIDS126730

However, all of C-3 monodesmosides [prosapogenin CP (2), dipsacus saponin B (6), and dipsacus saponin C (7)] evoked hemolysis directly on the erythrocytes [1].

High impact information on AIDS126730

The biological activity of compounds 1-10, 12, and 13 and prosapogenin 1b were examined against pancreatic lipase [2].
A novel prosapogenin (3) was obtained on the alkaline hydrolysis of 1 and its structure defined as 3-O-[beta-D-glucopyranosyl(1-->4)-beta-D-glucopyranosyl(1-->3)-alpha-L- rhamnopyranosyl(1-->2)-beta-D-xylopyranosyl] hederagenin [3].
The partialy hydrolysis products of formosanin C, dioscin (II) and prosapogenin A of dioscin (III), also increased 3H-thymidine incorporation of Con A-stimulated lymphocytes maximally at 0.01 micrograms/ml, whereas formosanin C did so at 0.0001 micrograms/ml [4].

References

In vitro anticomplementary activity of hederagenin saponins isolated from roots of Dipsacus asper. Oh, S.R., Jung, K.Y., Son, K.H., Park, S.H., Lee, I.S., Ahn, K.S., Lee, H.K. Arch. Pharm. Res. (1999) [Pubmed]
New biologically active triterpenoid saponins from Scabiosa tschiliensis. Zheng, Q., Koike, K., Han, L.K., Okuda, H., Nikaido, T. J. Nat. Prod. (2004) [Pubmed]
Triterpenoid saponins from Cephalaria transsylvanica. Kirmizigül, S., Anil, H., Rose, M.E. J. Nat. Prod. (1996) [Pubmed]
Immunomodulating effects of the hydrolysis products of formosanin C and beta-ecdysone from Paris formosana Hayata. Chiang, H.C., Wang, J.J., Wu, R.T. Anticancer Res. (1992) [Pubmed]

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