The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

PNLIP  -  pancreatic lipase

Homo sapiens

Synonyms: PL, PNLIPD, PTL, Pancreatic lipase, Pancreatic triacylglycerol lipase
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of PNLIP


Psychiatry related information on PNLIP


High impact information on PNLIP

  • Determination of the three-dimensional structure of pancreatic lipase has revealed the presence of two domains: an amino-terminal domain, at residues 1-336 containing the active site and a carboxy-terminal domain at residues 337-449 (ref. 6). Procolipase binds exclusively to the C-terminal domain of lipase [7].
  • Pancreatic lipase (triacylglycerol acyl hydrolase) fulfills a key function in dietary fat absorption by hydrolysing triglycerides into diglycerides and subsequently into monoglycerides and free fatty acids [8].
  • Under simulated physiological conditions, hydrolysis of emulsified fat droplets by human pancreatic lipase in the presence of colipase and bile salt micelles proceeds with the sequential formation of two visible product phases [9].
  • Human milk fat globules require colipase to be hydrolyzed by pancreatic lipase in the presence of bile salts [10].
  • At pH 8.0 in 4 mM sodium taurodeoxycholate, lipase activity was due to pancreatic lipase in samples from normal and steatorrheic individuals and was proportional to the concentration of endogenous colipase in samples that could be activated by exogenous colipase [2].

Chemical compound and disease context of PNLIP


Biological context of PNLIP


Anatomical context of PNLIP


Associations of PNLIP with chemical compounds


Enzymatic interactions of PNLIP


Regulatory relationships of PNLIP


Other interactions of PNLIP

  • Both PL and PLRP2 hydrolyzed RP solubilized in a vesicle rich-solution, and a synergic phenomenon between the two lipases was enlighten [16].
  • The protein encoded by the pancreatic colipase (CLPS) gene is an essential cofactor needed by pancreatic triglyceride lipase (PNLIP) for efficient dietary lipid hydrolysis [29].
  • Human hepatic lipase and lipoprotein lipase share extensive homology with pancreatic lipase, suggesting that the three proteins are members of a small gene family [23].
  • An Alu sequence is conserved in the homologous introns of hPL and the lipoprotein lipase-encoding gene [30].
  • Indirect evidence for this new function of the PL C-terminal domain has been provided by studies with monoclonal antibodies directed against the beta5' loop [1].

Analytical, diagnostic and therapeutic context of PNLIP


  1. The C-terminal domain of pancreatic lipase: functional and structural analogies with c2 domains. Chahinian, H., Sias, B., Carrière, F. Curr. Protein Pept. Sci. (2000) [Pubmed]
  2. Colipase and maximally activated pancreatic lipase in normal subjects and patients with steatorrhea. Gaskin, K.J., Durie, P.R., Hill, R.E., Lee, L.M., Forstner, G.G. J. Clin. Invest. (1982) [Pubmed]
  3. Immunoreactive pancreatic lipase test for neonatal detection of cystic fibrosis. Hammond, K.B., Ask, C.G., Watts, D.C. Lancet (1984) [Pubmed]
  4. Mixed triglyceride breath test: a noninvasive test of pancreatic lipase activity in the duodenum. Vantrappen, G.R., Rutgeerts, P.J., Ghoos, Y.F., Hiele, M.I. Gastroenterology (1989) [Pubmed]
  5. Role of nonpancreatic lipolytic activity in exocrine pancreatic insufficiency. Abrams, C.K., Hamosh, M., Dutta, S.K., Hubbard, V.S., Hamosh, P. Gastroenterology (1987) [Pubmed]
  6. The effect of hashish-smoking on serum levels of pancreatic lipase (EC in man. Dionyssiou-Asteriou, A., Kalofoutis, A., Maravelias, C., Koutselinis, A. J. Toxicol. Clin. Toxicol. (1990) [Pubmed]
  7. Structure of the pancreatic lipase-procolipase complex. van Tilbeurgh, H., Sarda, L., Verger, R., Cambillau, C. Nature (1992) [Pubmed]
  8. Structure of human pancreatic lipase. Winkler, F.K., D'Arcy, A., Hunziker, W. Nature (1990) [Pubmed]
  9. Watching fat digestion. Patton, J.S., Carey, M.C. Science (1979) [Pubmed]
  10. Hydrolysis of milk fat globules by pancreatic lipase. Role of colipase, phospholipase A2, and bile salts. Borgström, B., Erlanson-Albertsson, C. J. Clin. Invest. (1982) [Pubmed]
  11. Role of orlistat in the treatment of obese patients with type 2 diabetes. A 1-year randomized double-blind study. Hollander, P.A., Elbein, S.C., Hirsch, I.B., Kelley, D., McGill, J., Taylor, T., Weiss, S.R., Crockett, S.E., Kaplan, R.A., Comstock, J., Lucas, C.P., Lodewick, P.A., Canovatchel, W., Chung, J., Hauptman, J. Diabetes Care (1998) [Pubmed]
  12. Spectroscopic and kinetic studies of lipases solubilized in reverse micelles. Walde, P., Han, D., Luisi, P.L. Biochemistry (1993) [Pubmed]
  13. Immunochemical qualitative latex agglutination test for pancreatic lipase in serum evaluated for use in diagnosis of acute pancreatitis. Møller-Petersen, J., Klaerke, M., Dati, F., Toth, T. Clin. Chem. (1985) [Pubmed]
  14. Modulation of radiation-induced cytokine elevation associated with esophagitis and esophageal stricture by manganese superoxide dismutase-plasmid/liposome (SOD2-PL) gene therapy. Epperly, M.W., Gretton, J.A., DeFilippi, S.J., Greenberger, J.S., Sikora, C.A., Liggitt, D., Koe, G. Radiat. Res. (2001) [Pubmed]
  15. Antiobesity activity of pluronic L-101. Comai, K., Sullivan, A.C. International journal of obesity. (1980) [Pubmed]
  16. Pancreatic lipase and pancreatic lipase-related protein 2, but not pancreatic lipase-related protein 1, hydrolyze retinyl palmitate in physiological conditions. Reboul, E., Berton, A., Moussa, M., Kreuzer, C., Crenon, I., Borel, P. Biochim. Biophys. Acta (2006) [Pubmed]
  17. Two novel human pancreatic lipase related proteins, hPLRP1 and hPLRP2. Differences in colipase dependence and in lipase activity. Giller, T., Buchwald, P., Blum-Kaelin, D., Hunziker, W. J. Biol. Chem. (1992) [Pubmed]
  18. Reactivation of the totally inactive pancreatic lipase RP1 by structure-predicted point mutations. Roussel, A., de Caro, J., Bezzine, S., Gastinel, L., de Caro, A., Carrière, F., Leydier, S., Verger, R., Cambillau, C. Proteins (1998) [Pubmed]
  19. Polymorphisms in PNLIP, encoding pancreatic lipase, and associations with metabolic traits. Hegele, R.A., Ramdath, D.D., Ban, M.R., Carruthers, M.N., Carrington, C.V., Cao, H. J. Hum. Genet. (2001) [Pubmed]
  20. Discoordinate expression of pancreatic lipase and two related proteins in the human fetal pancreas. Yang, Y., Sanchez, D., Figarella, C., Lowe, M.E. Pediatr. Res. (2000) [Pubmed]
  21. Assignment of human pancreatic lipase gene (PNLIP) to chromosome 10q24-q26. Davis, R.C., Diep, A., Hunziker, W., Klisak, I., Mohandas, T., Schotz, M.C., Sparkes, R.S., Lusis, A.J. Genomics (1991) [Pubmed]
  22. Preparation and characterization of reference materials for human pancreatic lipase: BCR 693 (from human pancreatic juice) and BCR 694 (recombinant). Lessinger, J.M., Arzoglou, P., Ramos, P., Visvikis, A., Parashou, S., Calam, D., Profilis, C., Férard, G. Clin. Chem. Lab. Med. (2003) [Pubmed]
  23. Cloning and characterization of human pancreatic lipase cDNA. Lowe, M.E., Rosenblum, J.L., Strauss, A.W. J. Biol. Chem. (1989) [Pubmed]
  24. Kinetics of the two-step hydrolysis of triacylglycerol by pancreatic lipases. Lykidis, A., Mougios, V., Arzoglou, P. Eur. J. Biochem. (1995) [Pubmed]
  25. Human pancreatic triglyceride lipase expressed in yeast cells: purification and characterization. Yang, Y., Lowe, M.E. Protein Expr. Purif. (1998) [Pubmed]
  26. Digestion of human milk lipids: physiologic significance of sn-2 monoacylglycerol hydrolysis by bile salt-stimulated lipase. Hernell, O., Bläckberg, L. Pediatr. Res. (1982) [Pubmed]
  27. Hydrolysis of dietary fat by pancreatic lipase stimulates cholecystokinin release. Hildebrand, P., Petrig, C., Burckhardt, B., Ketterer, S., Lengsfeld, H., Fleury, A., Hadváry, P., Beglinger, C. Gastroenterology (1998) [Pubmed]
  28. Green tea extract (AR25) inhibits lipolysis of triglycerides in gastric and duodenal medium in vitro. Juhel, C., Armand, M., Pafumi, Y., Rosier, C., Vandermander, J., Lairon, D. J. Nutr. Biochem. (2000) [Pubmed]
  29. Putative association between a new polymorphism in exon 3 (Arg109Cys) of the pancreatic colipase gene and type 2 diabetes mellitus in two independent Caucasian study populations. Lindner, I., Helwig, U., Rubin, D., Li, Y., Fisher, E., Boeing, H., Möhlig, M., Spranger, J., Pfeiffer, A., Hampe, J., Schreiber, S., Döring, F., Schrezenmeir, J. Molecular nutrition & food research. (2005) [Pubmed]
  30. The human pancreatic lipase-encoding gene: structure and conservation of an Alu sequence in the lipase gene family. Sims, H.F., Jennens, M.L., Lowe, M.E. Gene (1993) [Pubmed]
  31. Secretion and contribution to lipolysis of gastric and pancreatic lipases during a test meal in humans. Carriere, F., Barrowman, J.A., Verger, R., Laugier, R. Gastroenterology (1993) [Pubmed]
  32. Cytological distribution of chorionic gonadotropin subunit and placental lactogen messenger RNA in neoplasms derived from human placenta. Hoshina, M., Hussa, R., Pattillo, R., Boime, I. J. Cell Biol. (1983) [Pubmed]
  33. The catalytic site residues and interfacial binding of human pancreatic lipase. Lowe, M.E. J. Biol. Chem. (1992) [Pubmed]
  34. Structural and functional roles of highly conserved serines in human lipoprotein lipase. Evidence that serine 132 is essential for enzyme catalysis. Faustinella, F., Smith, L.C., Semenkovich, C.F., Chan, L. J. Biol. Chem. (1991) [Pubmed]
WikiGenes - Universities