Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Chemical Compound Review:

ManNAc N-[(3S,4R,5S,6R)-2,4,5- trihydroxy-6...

Synonyms: SureCN5031262, CHEBI:63153, HMDB01129, bmse000056, KB-92341, ...

Galeano, B. et al.

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Disease relevance of ManNAc

The results also support evaluation of ManNAc as a treatment not only for HIBM but also for renal disorders involving proteinuria and hematuria due to podocytopathy and/or segmental splitting of the glomerular basement membrane [1].

References

Mutation in the key enzyme of sialic acid biosynthesis causes severe glomerular proteinuria and is rescued by N-acetylmannosamine. Galeano, B., Klootwijk, R., Manoli, I., Sun, M., Ciccone, C., Darvish, D., Starost, M.F., Zerfas, P.M., Hoffmann, V.J., Hoogstraten-Miller, S., Krasnewich, D.M., Gahl, W.A., Huizing, M. J. Clin. Invest. (2007) [Pubmed]

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