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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review


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Disease relevance of Hematuria


Psychiatry related information on Hematuria

  • The patients were children with VUR or normal genitourinary anatomy who presented with UTI or dysfunctional voiding and children screened for genitourinary problems such as hematuria, sibling reflux or bedwetting [6].

High impact information on Hematuria

  • We conclude that in patients with persistent microscopic hematuria, the incidence of thin-basement-membrane nephropathy is similar to that of idiopathic IgA nephropathy [7].
  • A possible cause of hematuria in patients taking warfarin [8].
  • For comparison, we also analyzed renal biopsy specimens from patients with idiopathic hematuria who had not received cyclosporine [9].
  • Its pathologic features include hematuria, high levels of circulating IgA-fibronectin (Fn) complexes, and glomerular deposition of IgA, complement C3, Fn and collagen [10].
  • We present here linkage of benign familial hematuria with the COL4A3 and COL4A4 genes at 2q35-37 (Zmax = 3.58 at theta = 0.0) [11].

Chemical compound and disease context of Hematuria


Biological context of Hematuria


Anatomical context of Hematuria


Gene context of Hematuria

  • Recently, the first mutation in the COL4A4 gene was identified in familial benign hematuria [27].
  • Mutations of COL4A3 and COL4A4 have been reported both in autosomal-recessive and autosomal-dominant ATS, as well as in benign familial hematuria (BFH) [28].
  • On the other hand, urinary IL-8 elevated only in acute type and were correlated with glomerular endocapillary proliferation and the degree of hematuria [29].
  • After adjusting for variables, such as sex, age, and infection status at study onset, high levels of parasite-specific IL-10 were a risk factor for reinfection, and high levels of IL-5 were associated with hematuria development [30].
  • Hypercalciuria in children with juvenile rheumatoid arthritis: association with hematuria [31].

Analytical, diagnostic and therapeutic context of Hematuria


  1. Renal disease in type I glycogen storage disease. Chen, Y.T., Coleman, R.A., Scheinman, J.I., Kolbeck, P.C., Sidbury, J.B. N. Engl. J. Med. (1988) [Pubmed]
  2. Skin immunopathology in system lupus erythematosus. Brown, M.M., Yount, W.J. JAMA (1980) [Pubmed]
  3. Acute hemorrhagic cystitis. Industrial exposure to the pesticide chlordimeform. Folland, D.S., Kimbrough, R.D., Cline, R.E., Swiggart, R.C., Schaffner, W. JAMA (1978) [Pubmed]
  4. Mesangial cell autoantigens in immunoglobulin A nephropathy and Henoch-Schönlein purpura. O'Donoghue, D.J., Darvill, A., Ballardie, F.W. J. Clin. Invest. (1991) [Pubmed]
  5. Diffuse esophageal leiomyomatosis with perirectal involvement mimicking Hirschsprung disease. Guillem, P., Delcambre, F., Cohen-Solal, L., Triboulet, J.P., Antignac, C., Heidet, L., Quandalle, P. Gastroenterology (2001) [Pubmed]
  6. A multivariate analysis of dysfunctional elimination syndrome, and its relationships with gender, urinary tract infection and vesicoureteral reflux in children. Chen, J.J., Mao, W., Homayoon, K., Steinhardt, G.F. J. Urol. (2004) [Pubmed]
  7. Thin-basement-membrane nephropathy in adults with persistent hematuria. Tiebosch, A.T., Frederik, P.M., van Breda Vriesman, P.J., Mooy, J.M., van Rie, H., van de Wiel, T.W., Wolters, J., Zeppenfeldt, E. N. Engl. J. Med. (1989) [Pubmed]
  8. A possible cause of hematuria in patients taking warfarin. Fowler, W.E., Boyarsky, S. N. Engl. J. Med. (1986) [Pubmed]
  9. Renal histopathologic alterations in patients treated with cyclosporine for uveitis. Palestine, A.G., Austin, H.A., Balow, J.E., Antonovych, T.T., Sabnis, S.G., Preuss, H.G., Nussenblatt, R.B. N. Engl. J. Med. (1986) [Pubmed]
  10. Uteroglobin is essential in preventing immunoglobulin A nephropathy in mice. Zheng, F., Kundu, G.C., Zhang, Z., Ward, J., DeMayo, F., Mukherjee, A.B. Nat. Med. (1999) [Pubmed]
  11. Benign familial hematuria due to mutation of the type IV collagen alpha4 gene. Lemmink, H.H., Nillesen, W.N., Mochizuki, T., Schröder, C.H., Brunner, H.G., van Oost, B.A., Monnens, L.A., Smeets, H.J. J. Clin. Invest. (1996) [Pubmed]
  12. Cyclophosphamide-induced cystitis and bladder cancer in patients with Wegener granulomatosis. Talar-Williams, C., Hijazi, Y.M., Walther, M.M., Linehan, W.M., Hallahan, C.W., Lubensky, I., Kerr, G.S., Hoffman, G.S., Fauci, A.S., Sneller, M.C. Ann. Intern. Med. (1996) [Pubmed]
  13. Suprofen, acute renal failure, and hematuria. Abreo, K., LaBarre, J. Ann. Intern. Med. (1986) [Pubmed]
  14. Pentamidine and hematuria. Shuster, M., Dunn, M. Ann. Intern. Med. (1986) [Pubmed]
  15. Mesna versus hyperhydration for the prevention of cyclophosphamide-induced hemorrhagic cystitis in bone marrow transplantation. Shepherd, J.D., Pringle, L.E., Barnett, M.J., Klingemann, H.G., Reece, D.E., Phillips, G.L. J. Clin. Oncol. (1991) [Pubmed]
  16. A phase I study of high-dose ifosfamide and escalating doses of carboplatin with autologous bone marrow support. Elias, A.D., Ayash, L.J., Eder, J.P., Wheeler, C., Deary, J., Weissman, L., Schryber, S., Hunt, M., Critchlow, J., Schnipper, L. J. Clin. Oncol. (1991) [Pubmed]
  17. Structure of the human type IV collagen gene COL4A3 and mutations in autosomal Alport syndrome. Heidet, L., Arrondel, C., Forestier, L., Cohen-Solal, L., Mollet, G., Gutierrez, B., Stavrou, C., Gubler, M.C., Antignac, C. J. Am. Soc. Nephrol. (2001) [Pubmed]
  18. Segregation of hematuria in thin basement membrane disease with haplotypes at the loci for Alport syndrome. Buzza, M., Wilson, D., Savige, J. Kidney Int. (2001) [Pubmed]
  19. A randomized comparison of ketorolac tromethamine and morphine for postoperative analgesia in critically ill children. Lieh-Lai, M.W., Kauffman, R.E., Uy, H.G., Danjin, M., Simpson, P.M. Crit. Care Med. (1999) [Pubmed]
  20. Platelet activation and prostacyclin supporting capacity in the loin pain hematuria syndrome. Siegler, R.L., Brewer, E.D., Hammond, E. Am. J. Kidney Dis. (1988) [Pubmed]
  21. Expandable metallic stent placement for nutcracker phenomenon. Segawa, N., Azuma, H., Iwamoto, Y., Sakamoto, T., Suzuki, T., Ueda, H., Yamamoto, K., Shimizu, T., Kichikawa, K., Katsuoka, Y. Urology (1999) [Pubmed]
  22. Mutations in the COL4A4 gene in thin basement membrane disease. Buzza, M., Dagher, H., Wang, Y.Y., Wilson, D., Babon, J.J., Cotton, R.G., Savige, J. Kidney Int. (2003) [Pubmed]
  23. Radiation nephritis following total-body irradiation and cyclophosphamide in preparation for bone marrow transplantation. Bergstein, J., Andreoli, S.P., Provisor, A.J., Yum, M. Transplantation (1986) [Pubmed]
  24. Macrophages in childhood IgA nephropathy. Nagata, M., Akioka, Y., Tsunoda, Y., Komatsu, Y., Kawaguchi, H., Yamaguchi, Y., Ito, K. Kidney Int. (1995) [Pubmed]
  25. Clinical manifestations of autosomal dominant polycystic kidney disease in patients older than 50 years. Milutinovic, J., Fialkow, P.J., Agodoa, L.Y., Phillips, L.A., Rudd, T.G., Sutherland, S. Am. J. Kidney Dis. (1990) [Pubmed]
  26. Newly diagnosed bladder cancer: the relationship of initial symptoms, degree of microhematuria and tumor marker status. Boman, H., Hedelin, H., Jacobsson, S., Holmäng, S. J. Urol. (2002) [Pubmed]
  27. The clinical spectrum of type IV collagen mutations. Lemmink, H.H., Schröder, C.H., Monnens, L.A., Smeets, H.J. Hum. Mutat. (1997) [Pubmed]
  28. COL4A3/COL4A4 mutations: from familial hematuria to autosomal-dominant or recessive Alport syndrome. Longo, I., Porcedda, P., Mari, F., Giachino, D., Meloni, I., Deplano, C., Brusco, A., Bosio, M., Massella, L., Lavoratti, G., Roccatello, D., Frascá, G., Mazzucco, G., Muda, A.O., Conti, M., Fasciolo, F., Arrondel, C., Heidet, L., Renieri, A., De Marchi, M. Kidney Int. (2002) [Pubmed]
  29. Urinary levels of chemokines (MCAF/MCP-1, IL-8) reflect distinct disease activities and phases of human IgA nephropathy. Yokoyama, H., Wada, T., Furuichi, K., Segawa, C., Shimizu, M., Kobayashi, K., Su, S., Mukaida, N., Matsushima, K. J. Leukoc. Biol. (1998) [Pubmed]
  30. Immune responses induced by repeated treatment do not result in protective immunity to Schistosoma haematobium: interleukin (IL)-5 and IL-10 responses. van den Biggelaar, A.H., Borrmann, S., Kremsner, P., Yazdanbakhsh, M. J. Infect. Dis. (2002) [Pubmed]
  31. Hypercalciuria in children with juvenile rheumatoid arthritis: association with hematuria. Stapleton, F.B., Hanissian, A.S., Miller, L.A. J. Pediatr. (1985) [Pubmed]
  32. Hematuria and red cell casts in typical diabetic nephropathy. O'Neill, W.M., Wallin, J.D., Walker, P.D. Am. J. Med. (1983) [Pubmed]
  33. Safety of losartan in hypertensive patients with thiazide-induced hyperuricemia. Shahinfar, S., Simpson, R.L., Carides, A.D., Thiyagarajan, B., Nakagawa, Y., Umans, J.G., Parks, J.H., Coe, F.L. Kidney Int. (1999) [Pubmed]
  34. Low-dose aspirin therapy is associated with improved allograft function and prolonged allograft survival after kidney transplantation. Grotz, W., Siebig, S., Olschewski, M., Strey, C.W., Peter, K. Transplantation (2004) [Pubmed]
  35. Intermittent chemotherapy with trichlorfon (metrifonate) reverses proteinuria, hematuria, and leukocyturia in urinary schistosomiasis: results of a three-year field study. Doehring, E., Feldmeier, H., Dafalla, A.A., Ehrich, J.H., Vester, U., Poggensee, U. J. Infect. Dis. (1984) [Pubmed]
  36. Foscarnet-induced crystalline glomerulonephritis with nephrotic syndrome and acute renal failure after kidney transplantation. Zanetta, G., Maurice-Estepa, L., Mousson, C., Justrabo, E., Daudon, M., Rifle, G., Tanter, Y. Transplantation (1999) [Pubmed]
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