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Chemical Compound Review:

AC1L97CN 2-[2-[(3R,4R,5S,6R)-3- acetamido-2-[[[(2R...

Synonyms:

Doublet, P. et al., Doublet, P. et al., Auger, G. et al.

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Disease relevance of UDP-N-acetylmuramoyl-L-alanine

The glutamate racemase activity from Escherichia coli is regulated by peptidoglycan precursor UDP-N-acetylmuramoyl-L-alanine [1].

High impact information on UDP-N-acetylmuramoyl-L-alanine

In vitro, the glutamate racemase activity shows an absolute requirement for UDP-N-acetylmuramoyl-L-alanine (UDP-MurNAc-L-Ala), the substrate of the D-glutamic acid-adding enzyme which catalyzes the subsequent step in the pathway for peptidoglycan synthesis [1].
Large-scale preparation, purification, and crystallization of UDP-N-acetylmuramoyl-L-alanine: D-glutamate ligase from Escherichia coli [2].

Gene context of UDP-N-acetylmuramoyl-L-alanine

UDP-N-acetylmuramoyl-L-alanine (UDP-MurNAc-L-Ala), which is the nucleotide substrate of the D-glutamic-acid-adding enzyme (the murD gene product) catalyzing the subsequent step in the pathway for peptidoglycan synthesis, appears to be an effector of the racemase activity [3].

References

The glutamate racemase activity from Escherichia coli is regulated by peptidoglycan precursor UDP-N-acetylmuramoyl-L-alanine. Doublet, P., van Heijenoort, J., Mengin-Lecreulx, D. Biochemistry (1994) [Pubmed]
Large-scale preparation, purification, and crystallization of UDP-N-acetylmuramoyl-L-alanine: D-glutamate ligase from Escherichia coli. Auger, G., Martin, L., Bertrand, J., Ferrari, P., Fanchon, E., Vaganay, S., Pétillot, Y., van Heijenoort, J., Blanot, D., Dideberg, O. Protein Expr. Purif. (1998) [Pubmed]
The murI gene of Escherichia coli is an essential gene that encodes a glutamate racemase activity. Doublet, P., van Heijenoort, J., Bohin, J.P., Mengin-Lecreulx, D. J. Bacteriol. (1993) [Pubmed]

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