Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Chemical Compound Review:

SureCN14149814 (3S)-10,13-dimethyl- 2,3,4,7,8,9,11,12,14...

Synonyms: AC1L98QV, C03836, 3beta-Hydroxy-delta5-steroid

Ghraf, R. et al., Shivanandappa, T. et al., Gustafsson, S.A.

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High impact information on C03836

3beta-Hydroxy-Delta5-steroid dehydrogenase is an important enzyme of steroid hormone biosynthesis present in steroidogenic tissues like adrenal, testis, and ovary of vertebrates [1].
Cyanoketone-induced inhibition of adrenal 3beta-hydroxy-delta5-steroid oxidoreductase activity in female and male rats in vitro [2].
3) The activities of cytoplasmic 3beta-hydroxy-delta5-steroid dehydrogenase and microsomal 7alpha-hydroxylase show no sex differences and are not influenced by any interference with the endocrine balance [3].

References

A colorimetric assay method for 3beta-hydroxy-delta5-steroid dehydrogenase. Shivanandappa, T., Venkatesh, S. Anal. Biochem. (1997) [Pubmed]
Cyanoketone-induced inhibition of adrenal 3beta-hydroxy-delta5-steroid oxidoreductase activity in female and male rats in vitro. Gustafsson, S.A. Acta Endocrinol. (1976) [Pubmed]
The hypophysis in the regulation of androgen and oestrogen dependent enzyme activities of steroid hormone metabolism in rat liver cytosol. Ghraf, R., Lax, E.R., Schriefers, H. Hoppe-Seyler's Z. Physiol. Chem. (1975) [Pubmed]

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