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Chemical Compound Review

caproyl-CoA     [(2R,3S,4R,5R)-5-(6- aminopurin-9-yl)-2...

Synonyms: CHEMBL1949895, HMDB02845, AC1L99MU, caproyl-coenzyme A, 6-carboxyhexanoyl-coenzyme A
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High impact information on hexanoyl-coenzyme a

  • Short-chain acyl-CoA dehydrogenase (hSCAD) catalyzes the first matrix step in the mitochondrial beta-oxidation cycle with optimal activity toward butyryl- and hexanoyl-CoA [1].
  • Comparison of steady-state kinetic constants of glutaryl-CoA dehydrogenase with glutaryl-CoA and the alternative substrates, pentanoyl-CoA and hexanoyl-CoA, suggests that the gamma-carboxyl group of glutaryl-CoA stabilizes the enzyme-substrate complex by at least 5.7 kJ/mol, perhaps by interaction with Arg94 or Ser98 [2].
  • The pH optimum of the purified enzyme progressively increased with the chain length of the substrate, with hexanoyl-CoA showing a pH optimum at 4.5 and stearoyl-CoA at 7 [3].

Anatomical context of hexanoyl-coenzyme a

  • Measurement of short-chain acyl-CoA dehydrogenase (SCAD) in cultured skin fibroblasts with hexanoyl-CoA as a competitive inhibitor to eliminate the contribution of medium-chain acyl-CoA dehydrogenase [4].


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