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Chemical Compound Review

stearyl-CoA     [5-(6-aminopurin-9-yl)-4- hydroxy-2...

Synonyms: AGN-PC-00BZ8T, AC1L1AQN, AR-1H5732, AC1Q68ZH, 172047-EP2272843A1, ...
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Disease relevance of stearoyl-CoA

  • Treatment of mice with SCD1 ASOs resulted in prevention of diet-induced obesity with concomitant reductions in SCD1 expression and the ratio of oleate to stearoyl-CoA in tissues and plasma [1].
  • Using chemically synthesized [1-(14)C] (R,S) 3-hydroxyeicosanoyl-CoA, we investigated the biochemical characteristics of the dehydration and reduction steps of stearoyl-CoA elongation [2].
  • On the other hand, stearoyl-CoA desaturation activity was absent in Novikoff hepatoma [3].
  • Stearoyl-CoA desaturase 1 coding sequences and antisense RNA affect lipid secretion in transfected chicken LMH hepatoma cells [4].
  • A particulate fraction prepared from Mycobacterium phlei grown in a metal-deficient medium exhibited a greatly reduced activity of stearoyl-CoA desaturase compared to that from normally grown cells [5].

High impact information on stearoyl-CoA


Chemical compound and disease context of stearoyl-CoA


Biological context of stearoyl-CoA


Anatomical context of stearoyl-CoA


Associations of stearoyl-CoA with other chemical compounds


Gene context of stearoyl-CoA


Analytical, diagnostic and therapeutic context of stearoyl-CoA


  1. Prevention of obesity in mice by antisense oligonucleotide inhibitors of stearoyl-CoA desaturase-1. Jiang, G., Li, Z., Liu, F., Ellsworth, K., Dallas-Yang, Q., Wu, M., Ronan, J., Esau, C., Murphy, C., Szalkowski, D., Bergeron, R., Doebber, T., Zhang, B.B. J. Clin. Invest. (2005) [Pubmed]
  2. Dehydration of 3-hydroxyacyl-CoA in brain very-long-chain fatty acid synthesis. Knoll, A., Bessoule, J.J., Sargueil, F., Cassagne, C. Neurochem. Int. (1999) [Pubmed]
  3. Stearoyl-coenzyme A desaturase activity in Novikoff hepatoma. Prasad, M.R., Joshi, V.C. Lipids (1979) [Pubmed]
  4. Stearoyl-CoA desaturase 1 coding sequences and antisense RNA affect lipid secretion in transfected chicken LMH hepatoma cells. Diot, C., Lefèvre, P., Hervé, C., Belloir, B., Narce, M., Damon, M., Poisson, J.P., Mallard, J., Douaire, M. Arch. Biochem. Biophys. (2000) [Pubmed]
  5. Effect of metal ions in the culture medium on the stearoyl-coenzyme A desaturase activity of Mycobacterium phlei. Kashiwabara, Y., Nakagawa, H., Matsuki, G., Sato, R. J. Biochem. (1975) [Pubmed]
  6. Highly selective hydrolysis of fatty acyl-CoAs by calcium-independent phospholipase A2beta. Enzyme autoacylation and acyl-CoA-mediated reversal of calmodulin inhibition of phospholipase A2 activity. Jenkins, C.M., Yan, W., Mancuso, D.J., Gross, R.W. J. Biol. Chem. (2006) [Pubmed]
  7. Brain adipocytokine action and metabolic regulation. Ahima, R.S., Qi, Y., Singhal, N.S., Jackson, M.B., Scherer, P.E. Diabetes (2006) [Pubmed]
  8. Transcytosis of albumin in astrocytes activates the sterol regulatory element-binding protein-1, which promotes the synthesis of the neurotrophic factor oleic acid. Tabernero, A., Velasco, A., Granda, B., Lavado, E.M., Medina, J.M. J. Biol. Chem. (2002) [Pubmed]
  9. Disruption of the gene encoding the acyl-CoA-binding protein (ACB1) perturbs acyl-CoA metabolism in Saccharomyces cerevisiae. Schjerling, C.K., Hummel, R., Hansen, J.K., Borsting, C., Mikkelsen, J.M., Kristiansen, K., Knudsen, J. J. Biol. Chem. (1996) [Pubmed]
  10. delta 9 Acyl-lipid desaturases of cyanobacteria. Molecular cloning and substrate specificities in terms of fatty acids, sn-positions, and polar head groups. Sakamoto, T., Wada, H., Nishida, I., Ohmori, M., Murata, N. J. Biol. Chem. (1994) [Pubmed]
  11. Spin-labeling of Escherichia coli membrane by enzymatic synthesis of phosphatidylglycerol and divalent cation-induced interaction of phosphatidylglycerol with membrane proteins. Takeuchi, Y., Ohnishi, S.I., Ishinaga, M., Kito, M. Biochim. Biophys. Acta (1978) [Pubmed]
  12. Bacterial synthesis of active rat stearyl-CoA desaturase lacking the 26-residue amino-terminal amino acid sequence. Strittmatter, P., Thiede, M.A., Hackett, C.S., Ozols, J. J. Biol. Chem. (1988) [Pubmed]
  13. Mechanism of rat liver microsomal stearyl-CoA desaturase. Studies of the substrate specificity, enzyme-substrate interactions, and the function of lipid. Enoch, H.G., Catalá, A., Strittmatter, P. J. Biol. Chem. (1976) [Pubmed]
  14. Cold resistance of the brain during hibernation: the role of stearyl CoA desaturase in brain and liver as the source for monoenes. Goldman, S.S. J. Neurochem. (1978) [Pubmed]
  15. Keratinocyte growth factor induces lipogenesis in alveolar type II cells through a sterol regulatory element binding protein-1c-dependent pathway. Chang, Y., Edeen, K., Lu, X., De Leon, M., Mason, R.J. Am. J. Respir. Cell Mol. Biol. (2006) [Pubmed]
  16. Investigation of microsomal oxygenases of biosynthetic processes. Stearyl-CoA desaturase of adipose tissue and liver. Seifried, H.E., Gaylor, J.L. J. Biol. Chem. (1976) [Pubmed]
  17. The induction and characterization of rat liver stearyl-CoA desaturase mRNA. Thiede, M.A., Strittmatter, P. J. Biol. Chem. (1985) [Pubmed]
  18. Sex-related differences in the enhancing effects of perfluoro-octanoic acid on stearoyl-CoA desaturase and its influence on the acyl composition of phospholipid in rat liver. Comparison with clofibric acid and tiadenol. Kawashima, Y., Uy-Yu, N., Kozuka, H. Biochem. J. (1989) [Pubmed]
  19. Targeted disruption of stearoyl-CoA desaturase1 gene in mice causes atrophy of sebaceous and meibomian glands and depletion of wax esters in the eyelid. Miyazaki, M., Man, W.C., Ntambi, J.M. J. Nutr. (2001) [Pubmed]
  20. The activity of partial reactions in the chain elongation of palmitoyl-CoA and stearoyl-CoA by mouse brain microsomes. Bernert, J.T., Bourre, J.M., Baumann, N.A., Sprecher, H. J. Neurochem. (1979) [Pubmed]
  21. Elongation of fatty acids by microsomal fractions from the brain of the developing rat. Brophy, P.J., Vance, D.E. Biochem. J. (1975) [Pubmed]
  22. Increase in hepatic content of oleic acid induced by dehydroepiandrosterone in the rat. Imai, K., Koyama, M., Kudo, N., Shirahata, A., Kawashima, Y. Biochem. Pharmacol. (1999) [Pubmed]
  23. Feed restriction significantly alters lipogenic gene expression in broiler breeder chickens. Richards, M.P., Poch, S.M., Coon, C.N., Rosebrough, R.W., Ashwell, C.M., McMurtry, J.P. J. Nutr. (2003) [Pubmed]
  24. Isolation and characterization of an acyl-CoA thioesterase from dark-grown Euglena gracilis. Larson, J.D., Kolattukudy, P.E. Arch. Biochem. Biophys. (1985) [Pubmed]
  25. Mutants of glucokinase cause hypoglycaemia- and hyperglycaemia syndromes and their analysis illuminates fundamental quantitative concepts of glucose homeostasis. Davis, E.A., Cuesta-Muñoz, A., Raoul, M., Buettger, C., Sweet, I., Moates, M., Magnuson, M.A., Matschinsky, F.M. Diabetologia (1999) [Pubmed]
  26. A stearoyl-CoA-specific Delta 9 fatty acid desaturase from the basidiomycete Lentinula edodes. Sakai, H., Kajiwara, S. Biosci. Biotechnol. Biochem. (2003) [Pubmed]
  27. Nuclear hormone receptor NHR-49 controls fat consumption and fatty acid composition in C. elegans. Van Gilst, M.R., Hadjivassiliou, H., Jolly, A., Yamamoto, K.R. PLoS Biol. (2005) [Pubmed]
  28. Characterization of the interaction of amphipathic cytochrome b5 with stearyl coenzyme A desaturase and NADPH:cytochrome P-450 reductase. Dailey, H.A., Strittmatter, P. J. Biol. Chem. (1980) [Pubmed]
  29. Mössbauer studies of alkane omega-hydroxylase: evidence for a diiron cluster in an integral-membrane enzyme. Shanklin, J., Achim, C., Schmidt, H., Fox, B.G., Münck, E. Proc. Natl. Acad. Sci. U.S.A. (1997) [Pubmed]
  30. Stearyl-CoA desaturation capacity of the rat liver during regeneration after partial hepatectomy. Carreau, J.P., Mazliak, P., Frommel, D. Int. J. Biochem. (1981) [Pubmed]
  31. Stearoyl-CoA desaturase expression and fatty acid composition in milkfish (Chanos chanos) and grass carp (Ctenopharyngodon idella) during cold acclimation. Hsieh, S.L., Kuo, C.M. Comp. Biochem. Physiol. B, Biochem. Mol. Biol. (2005) [Pubmed]
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