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Chemical Compound Review:

sulfopyruvate 2-oxo-3-sulfo-propanoic acid

Synonyms: AG-H-98619, CHEBI:16894, HMDB04045, CTK5H9649, DB02156, ...

Graupner, M. et al., Liu, S. et al.

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High impact information on sulfopyruvate

The crystal structure of the mutase with Mg(II) and sulfopyruvate (a phosphonopyruvate analogue) bound showed that the substrate is anchored to the active site by the Mg(II), and shielded from solvent by a large loop (residues 115-133) [1].
Both enzymes were found to use either NADH or NADPH to reduce sulfopyruvate to (S)-sulfolactate, but the V(max)/K(m) value for the reduction of sulfopyruvate by NADH using the MJ1425-encoded enzyme was 20 times greater than any other combination of enzymes and pyridine nucleotides [2].

References

Conformational flexibility of PEP mutase. Liu, S., Lu, Z., Han, Y., Jia, Y., Howard, A., Dunaway-Mariano, D., Herzberg, O. Biochemistry (2004) [Pubmed]
Identification of an archaeal 2-hydroxy acid dehydrogenase catalyzing reactions involved in coenzyme biosynthesis in methanoarchaea. Graupner, M., Xu, H., White, R.H. J. Bacteriol. (2000) [Pubmed]

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