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Chemical Compound Review:

abacavir [(1R,4R)-4-[2-amino-6- (cyclopropylamino)pu...

Synonyms: Epzicom, Ziagen, CHEMBL1380, Abacavir (INN), SureCN38632, ...

Cysique, L.A. et al., Barber, T.J. et al., Bisset, L.R. et al.

Hall, Brown, Romero, McArthur, Price, Halman, Cysique, Simpson, Marder, Catalan, Power, Torres, Symonds, Atkinson, Sacktor, Clifford, Brew,

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of abacavir

Combined effect of zidovudine (ZDV), lamivudine (3TC) and abacavir (ABC) antiretroviral therapy in suppressing in vitro FIV replication [1].

High impact information on abacavir

METHODS: We used data from the abacavir (ABC) ADC trial (n = 78) and examined the patients' neuropsychologic performance change with the Reliable Change Index according to 3 cutoff groups: (1) CSF viral load (VL) <100 copies/mL, (2) CSF beta-2 microglobulin (beta2m) <2.2 mg/L, and (3) CSF VL and CSF beta2m below cutoffs [2].

Associations of abacavir with other chemical compounds

Abacavir may also act as an inhibitor of alcohol dehydrogenase, which raises the possibility of disulfiram-like reactions (if complete inhibition occurs) or reduced alcohol tolerance (if partial inhibition occurs) occurring with abacavir therapy [3].

References

Combined effect of zidovudine (ZDV), lamivudine (3TC) and abacavir (ABC) antiretroviral therapy in suppressing in vitro FIV replication. Bisset, L.R., Lutz, H., Böni, J., Hofmann-Lehmann, R., Lüthy, R., Schüpbach, J. Antiviral Res. (2002) [Pubmed]
Undetectable cerebrospinal fluid HIV RNA and beta-2 microglobulin do not indicate inactive AIDS dementia complex in highly active antiretroviral therapy-treated patients. Cysique, L.A., Brew, B.J., Halman, M., Catalan, J., Sacktor, N., Price, R.W., Brown, S., Atkinson, J.H., Clifford, D.B., Simpson, D., Torres, G., Hall, C., Power, C., Marder, K., McArthur, J.C., Symonds, W., Romero, C. J. Acquir. Immune Defic. Syndr. (2005) [Pubmed]
Are disulfiram-like reactions associated with abacavir-containing antiretroviral regimens in clinical practice? Barber, T.J., Marett, B., Waldron, S., Portsmouth, S., Mackie, N.E., Weston, R., Winston, A. AIDS (2007) [Pubmed]

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