Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Chemical Compound Review:

CHEBI:129 (6R)-3-methylidene-6-propan- 2-yl-cyclohexene

Synonyms: CPD-8768, AC1L9E4Z, C11392, (-)-beta-Phellandrene, (4S)-beta-phellandrene, ...

Reiling, K.K. et al., Hoelscher, D.J. et al.

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Disease relevance of C11392

Heterologous expression of the gene in Escherichia coli provided a soluble recombinant enzyme capable of catalyzing the divalent metal ion-dependent conversion of geranyl diphosphate to (+)-3-carene and to lesser amounts of limonene, myrcene, 4-carene and beta-phellandrene [1].

High impact information on C11392

Analysis of culture extracts or headspace by gas chromatography-mass spectrometry confirmed the in vivo production of the diterpenes casbene, kaur-15-ene, and kaur-16-ene and the monoterpenes alpha-pinene, myrcene, sabinene, 3-carene, alpha-terpinene, limonene, beta-phellandrene, alpha-terpinene, and terpinolene [2].

References

A cDNA clone for 3-carene synthase from Salvia stenophylla. Hoelscher, D.J., Williams, D.C., Wildung, M.R., Croteau, R. Phytochemistry (2003) [Pubmed]
Mono and diterpene production in Escherichia coli. Reiling, K.K., Yoshikuni, Y., Martin, V.J., Newman, J., Bohlmann, J., Keasling, J.D. Biotechnol. Bioeng. (2004) [Pubmed]

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