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Chemical Compound Review:

Tereben 1-methyl-4-propan-2-ylidene- cyclohexene

Synonyms: Terpinolen, TERPINOLENE, Isoterpinene, Nofmer TP, CHEMBL454697, ...

Kim, H.G. et al., Grassmann, J. et al.

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Disease relevance of Nofmer TP

Ellagic acid derived from T. chebula fruits exerted a potent inhibitory effect against C. perfringens and E. coli, but little or no inhibition was observed with treatments of behenic acid, P-caryophyllene, eugenol, isoquercitrin, oleic acid, ca-phellandrene, 3-sitosterol, stearic acid, a-terpinene, terpinen-4-ol, terpinolene, or triacontanoic acid [1].

High impact information on Nofmer TP

In order to test the mechanism by which terpinolene protects LDL from oxidation, LDL from human blood plasma enriched in terpinolene was isolated [2].
The monoterpene terpinolene from the oil of Pinus mugo L. in concert with alpha-tocopherol and beta-carotene effectively prevents oxidation of LDL [2].

References

Growth-inhibiting activity of active component isolated from Terminalia chebula fruits against intestinal bacteria. Kim, H.G., Cho, J.H., Jeong, E.Y., Lim, J.H., Lee, S.H., Lee, H.S. J. Food Prot. (2006) [Pubmed]
The monoterpene terpinolene from the oil of Pinus mugo L. in concert with alpha-tocopherol and beta-carotene effectively prevents oxidation of LDL. Grassmann, J., Hippeli, S., Spitzenberger, R., Elstner, E.F. Phytomedicine (2005) [Pubmed]

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