Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Chemical Compound Review:

CHEBI:29616 (4aS,4bR,10aS)-1,1,4a- trimethyl-7-propan-2...

Synonyms: LMPR0104050007, AC1L9EQ8, C11879, 122712-77-0, Levopimaradiene, ...

Byun-McKay, A. et al., Ro, D.K. et al., Peters, R.J. et al., Schepmann, H.G. et al.

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High impact information on Levopimaradiene

Alternative deprotonations of the terminal abietenyl carbocation provide a mixture of abietadiene, levopimaradiene, and neoabietadiene, and this product profile varies as a function of pH [1].
Based on amino acid sequence similarity, the cDNAs resemble Norway spruce (Picea abies) (-)-linalool synthase (mono-TPS; PsTPS-Linl) and levopimaradiene/abietadiene synthase (di-TPS; PsTPS-LASl), and grand fir (Abies grandis) delta-selinene synthase (sesqui-TPS; PsTPS-Sell) [2].
Levopimaradiene synthase, which catalyzes the initial cyclization step in ginkgolide biosynthesis, was cloned and functionally characterized [3].
Diterpene resin acid biosynthesis in loblolly pine (Pinus taeda): Functional characterization of abietadiene/levopimaradiene synthase (PtTPS-LAS) cDNA and subcellular targeting of PtTPS-LAS and abietadienol/abietadienal oxidase (PtAO, CYP720B1) [4].

References

Abietadiene synthase catalysis: mutational analysis of a prenyl diphosphate ionization-initiated cyclization and rearrangement. Peters, R.J., Croteau, R.B. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
Wound-induced terpene synthase gene expression in Sitka spruce that exhibit resistance or susceptibility to attack by the white pine weevil. Byun-McKay, A., Godard, K.A., Toudefallah, M., Martin, D.M., Alfaro, R., King, J., Bohlmann, J., Plant, A.L. Plant Physiol. (2006) [Pubmed]
Cloning and characterization of Ginkgo biloba levopimaradiene synthase which catalyzes the first committed step in ginkgolide biosynthesis. Schepmann, H.G., Pang, J., Matsuda, S.P. Arch. Biochem. Biophys. (2001) [Pubmed]
Diterpene resin acid biosynthesis in loblolly pine (Pinus taeda): Functional characterization of abietadiene/levopimaradiene synthase (PtTPS-LAS) cDNA and subcellular targeting of PtTPS-LAS and abietadienol/abietadienal oxidase (PtAO, CYP720B1). Ro, D.K., Bohlmann, J. Phytochemistry (2006) [Pubmed]

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