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Chemical Compound Review

DRib     (2R,3R,4S)-2- (hydroxymethyl)pyrrolidine- 3...

Synonyms: IMINORIBITOL, CHEMBL261634, SureCN1223493, CHEBI:532207, AC1L9JBR, ...
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High impact information on IMINORIBITOL

  • An inhibitor with a protonated 1,4-dideoxy-1,4-imino-D-ribitol moiety, a 4-azasugar mimic, at the depurination site in the tetraloop of a 14mer oligonucleotide with a 5 bp duplex stem structure had previously been shown to bind to RTA with a K(d) of 480 nM, which improved to 12 nM upon addition of adenine [1].
  • The structure of TB-PNP was also solved to 2.0 A with 9-deazahypoxanthine (9dHX), iminoribitol (IR), and PO(4) to reconstruct the ImmH complex with its separate components [2].
  • Binding of these inhibitors to nonspecific nucleoside hydrolase occurs primarily via interaction with the iminoribitol, a ribooxocarbenium ion analogue of the transition state [3].

Associations of IMINORIBITOL with other chemical compounds


  1. Inhibition of ricin A-chain with pyrrolidine mimics of the oxacarbenium ion transition state. Roday, S., Amukele, T., Evans, G.B., Tyler, P.C., Furneaux, R.H., Schramm, V.L. Biochemistry (2004) [Pubmed]
  2. Structures of purine nucleoside phosphorylase from Mycobacterium tuberculosis in complexes with immucillin-H and its pieces. Shi, W., Basso, L.A., Santos, D.S., Tyler, P.C., Furneaux, R.H., Blanchard, J.S., Almo, S.C., Schramm, V.L. Biochemistry (2001) [Pubmed]
  3. Iminoribitol transition state analogue inhibitors of protozoan nucleoside hydrolases. Miles, R.W., Tyler, P.C., Evans, G.B., Furneaux, R.H., Parkin, D.W., Schramm, V.L. Biochemistry (1999) [Pubmed]
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