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Gene Review:

Tb927.7.4570 - nucleoside hydrolase

Trypanosoma brucei brucei strain 927/4 GUTat10.1

Miles, R.W. et al., Parkin, D.W. et al.

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High impact information on Tb927.7.4570

These compounds provide the first transition state analogue inhibitors for purine-specific nucleoside hydrolase [1].
Binding of these inhibitors to nonspecific nucleoside hydrolase occurs primarily via interaction with the iminoribitol, a ribooxocarbenium ion analogue of the transition state [1].
Several protozoan nucleoside hydrolase isozymes with distinct substrate specificities have been characterized [2].

References

Iminoribitol transition state analogue inhibitors of protozoan nucleoside hydrolases. Miles, R.W., Tyler, P.C., Evans, G.B., Furneaux, R.H., Parkin, D.W., Schramm, V.L. Biochemistry (1999) [Pubmed]
Isozyme-specific transition state inhibitors for the trypanosomal nucleoside hydrolases. Parkin, D.W., Limberg, G., Tyler, P.C., Furneaux, R.H., Chen, X.Y., Schramm, V.L. Biochemistry (1997) [Pubmed]

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