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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Chemical Compound Review: 

LP-149     (4S)-4-[[(3S,4S)-4-[[(2S)-2- [[(2S)-2...

Synonyms: LP 149, AC1L9N0D, 1fiv, 165074-99-7, ACE-NAL-VAL-STA-GLU-NAM
 
 
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Disease relevance of LP-149

  • The refined structure includes a peptidomimetic, statine-based inhibitor, LP-149, which is an even more potent inhibitor of HIV PR [1].
 

High impact information on LP-149

  • Both the inhibitor and the substrate are bound in the active site of the mutant protease in a similar mode, which also resembles the mode of binding of LP-149 to the native protease [2].

References

  1. Structure of an inhibitor complex of the proteinase from feline immunodeficiency virus. Wlodawer, A., Gustchina, A., Reshetnikova, L., Lubkowski, J., Zdanov, A., Hui, K.Y., Angleton, E.L., Farmerie, W.G., Goodenow, M.M., Bhatt, D. Nat. Struct. Biol. (1995) [Pubmed]
  2. Crystal structures of the inactive D30N mutant of feline immunodeficiency virus protease complexed with a substrate and an inhibitor. Laco, G.S., Schalk-Hihi, C., Lubkowski, J., Morris, G., Zdanov, A., Olson, A., Elder, J.H., Wlodawer, A., Gustchina, A. Biochemistry (1997) [Pubmed]
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