The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Chemical Compound Review

LP-149     (4S)-4-[[(3S,4S)-4-[[(2S)-2- [[(2S)-2...

Synonyms: LP 149, AC1L9N0D, 1fiv, 165074-99-7, ACE-NAL-VAL-STA-GLU-NAM
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of LP-149

  • The refined structure includes a peptidomimetic, statine-based inhibitor, LP-149, which is an even more potent inhibitor of HIV PR [1].

High impact information on LP-149

  • Both the inhibitor and the substrate are bound in the active site of the mutant protease in a similar mode, which also resembles the mode of binding of LP-149 to the native protease [2].


  1. Structure of an inhibitor complex of the proteinase from feline immunodeficiency virus. Wlodawer, A., Gustchina, A., Reshetnikova, L., Lubkowski, J., Zdanov, A., Hui, K.Y., Angleton, E.L., Farmerie, W.G., Goodenow, M.M., Bhatt, D. Nat. Struct. Biol. (1995) [Pubmed]
  2. Crystal structures of the inactive D30N mutant of feline immunodeficiency virus protease complexed with a substrate and an inhibitor. Laco, G.S., Schalk-Hihi, C., Lubkowski, J., Morris, G., Zdanov, A., Olson, A., Elder, J.H., Wlodawer, A., Gustchina, A. Biochemistry (1997) [Pubmed]
WikiGenes - Universities