Chemical Compound Review:
statine (3S,4S)-4-amino-3-hydroxy-6- methyl...
Synonyms:
AHMHA, AG-F-66134, AC1L3XJJ, KB-60617, CTK8G3203, ...
- Specificity and inhibition of proteases from human immunodeficiency viruses 1 and 2. Tomasselli, A.G., Hui, J.O., Sawyer, T.K., Staples, D.J., Bannow, C., Reardon, I.M., Howe, W.J., DeCamp, D.L., Craik, C.S., Heinrikson, R.L. J. Biol. Chem. (1990)
- X-ray structure and conformational dynamics of the HIV-1 protease in complex with the inhibitor SDZ283-910: agreement of time-resolved spectroscopy and molecular dynamics simulations. Ringhofer, S., Kallen, J., Dutzler, R., Billich, A., Visser, A.J., Scholz, D., Steinhauser, O., Schreiber, H., Auer, M., Kungl, A.J. J. Mol. Biol. (1999)
- SDZ PRI 053, an orally bioavailable human immunodeficiency virus type 1 proteinase inhibitor containing the 2-aminobenzylstatine moiety. Billich, A., Fricker, G., Müller, I., Donatsch, P., Ettmayer, P., Gstach, H., Lehr, P., Peichl, P., Scholz, D., Rosenwirth, B. Antimicrob. Agents Chemother. (1995)
- Crystal structures of the inactive D30N mutant of feline immunodeficiency virus protease complexed with a substrate and an inhibitor. Laco, G.S., Schalk-Hihi, C., Lubkowski, J., Morris, G., Zdanov, A., Olson, A., Elder, J.H., Wlodawer, A., Gustchina, A. Biochemistry (1997)
- Design and synthesis of hydroxyethylene-based peptidomimetic inhibitors of human beta-secretase. Hom, R.K., Gailunas, A.F., Mamo, S., Fang, L.Y., Tung, J.S., Walker, D.E., Davis, D., Thorsett, E.D., Jewett, N.E., Moon, J.B., John, V. J. Med. Chem. (2004)
- Novel renin inhibitors containing the amino acid statine. Boger, J., Lohr, N.S., Ulm, E.H., Poe, M., Blaine, E.H., Fanelli, G.M., Lin, T.Y., Payne, L.S., Schorn, T.W., LaMont, B.I., Vassil, T.C., Stabilito, I.I., Veber, D.F., Rich, D.H., Bopari, A.S. Nature (1983)
- X-ray structure of plasmepsin II complexed with a potent achiral inhibitor. Prade, L., Jones, A.F., Boss, C., Richard-Bildstein, S., Meyer, S., Binkert, C., Bur, D. J. Biol. Chem. (2005)
- Novel inhibition of porcine pepsin by a substituted piperidine. Preference for one of the enzyme conformers. Marcinkeviciene, J., Kopcho, L.M., Yang, T., Copeland, R.A., Glass, B.M., Combs, A.P., Falahatpisheh, N., Thompson, L. J. Biol. Chem. (2002)
- Molecular basis for selectivity of high affinity peptide antagonists for the gastrin-releasing peptide receptor. Tokita, K., Katsuno, T., Hocart, S.J., Coy, D.H., Llinares, M., Martinez, J., Jensen, R.T. J. Biol. Chem. (2001)
- Mechanism of Inhibition of beta-site amyloid precursor protein-cleaving enzyme (BACE) by a statine-based peptide. Marcinkeviciene, J., Luo, Y., Graciani, N.R., Combs, A.P., Copeland, R.A. J. Biol. Chem. (2001)
- Inhibition of cathepsin D by tripeptides containing statine analogs. Bessodes, M., Antonakis, K., Herscovici, J., Garcia, M., Rochefort, H., Capony, F., Lelièvre, Y., Scherman, D. Biochem. Pharmacol. (1999)
- Impeded progression of Friend disease in mice by an inhibitor of retroviral proteases. Lai, M.H., Tang, J., Wroblewski, V., Dee, A.G., Margolin, N., Vlahos, C., Bowdon, B., Buckheit, R., Colacino, J., Hui, K.Y. J. Acquir. Immune Defic. Syndr. (1993)
- Statine-containing renin inhibitor. Dissociation of blood pressure lowering and renin inhibition in sodium-deficient dogs. Blaine, E.H., Schorn, T.W., Boger, J. Hypertension (1984)
- X-ray studies of aspartic proteinase-statine inhibitor complexes. Cooper, J.B., Foundling, S.I., Blundell, T.L., Boger, J., Jupp, R.A., Kay, J. Biochemistry (1989)
- Pepstatin analogues as novel renin inhibitors. Guégan, R., Diaz, J., Cazaubon, C., Beaumont, M., Carlet, C., Clément, J., Demarne, H., Mellet, M., Richaud, J.P., Segondy, D. J. Med. Chem. (1986)
- Molecular docking and 3D-QSAR studies on the binding mechanism of statine-based peptidomimetics with beta-secretase. Zuo, Z., Luo, X., Zhu, W., Shen, J., Shen, X., Jiang, H., Chen, K. Bioorg. Med. Chem. (2005)
- Interaction of mouse submaxillary gland renin with a statine-containing, subnanomolar, competitive inhibitor. Poe, M., Perlow, D.S., Boger, J. J. Enzym. Inhib. (1985)
- Biological activity of aspartic proteinase inhibitors related to pepstatin. Gunn, J.M., Owens, R.A., Liu, W.S., Glover, G.I. Acta Biol. Med. Ger. (1981)
- Synthesis of all the stereoisomers of statine (4-amino-3-hydroxy-6-methylheptanoic acid). Inhibition of pepsin activity by N-carbobenzoxy-L-valyl-L-valyl-statine derived from the four stereoisomers. Liu, W.S., Smith, S.C., Glover, G.I. J. Med. Chem. (1979)
- Synthesis of the novel pi-(benzyloxymethyl)-protected histidine analogue of statine. Inhibition of penicillopepsin by pepstatin-derived peptides containing different statine side-chain derivatives. Maibaum, J., Rich, D.H. J. Med. Chem. (1989)
- 1,2,4-Triazolo[4,3-a]pyrazine derivatives with human renin inhibitory activity. 1. Synthesis and biological properties of alkyl alcohol and statine derivatives. Roberts, D.A., Bradbury, R.H., Brown, D., Faull, A., Griffiths, D., Major, J.S., Oldham, A.A., Pearce, R.J., Ratcliffe, A.H., Revill, J. J. Med. Chem. (1990)
- Anti-AIDS agents 49. Synthesis, anti-HIV, and anti-fusion activities of IC9564 analogues based on betulinic acid. Sun, I.C., Chen, C.H., Kashiwada, Y., Wu, J.H., Wang, H.K., Lee, K.H. J. Med. Chem. (2002)
- Structural locations and functional roles of new subsites S5, S6, and S7 in memapsin 2 (beta-secretase). Turner, R.T., Hong, L., Koelsch, G., Ghosh, A.K., Tang, J. Biochemistry (2005)
- Renin inhibitors. Syntheses of subnanomolar, competitive, transition-state analogue inhibitors containing a novel analogue of statine. Boger, J., Payne, L.S., Perlow, D.S., Lohr, N.S., Poe, M., Blaine, E.H., Ulm, E.H., Schorn, T.W., LaMont, B.I., Lin, T.Y. J. Med. Chem. (1985)
- 3D-quantitative structure-activity relationships of human immunodeficiency virus type-1 proteinase inhibitors: comparative molecular field analysis of 2-heterosubstituted statine derivatives-implications for the design of novel inhibitors. Kroemer, R.T., Ettmayer, P., Hecht, P. J. Med. Chem. (1995)
- Betulinic acid derivatives: a new class of specific inhibitors of human immunodeficiency virus type 1 entry. Soler, F., Poujade, C., Evers, M., Carry, J.C., Hénin, Y., Bousseau, A., Huet, T., Pauwels, R., De Clercq, E., Mayaux, J.F., Le Pecq, J.B., Dereu, N. J. Med. Chem. (1996)
- Distribution of pepstatin and statine following oral and intravenous administration in rats. Tissue localisation by whole body autoradiography. Grant, D.A., Ford, T.F., McCulloch, R.J. Biochem. Pharmacol. (1982)