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Chemical Compound Review:

AC1L9N1X [(2R,3S,4R,6S)-3,4,6- trihydroxyoxan-2...

Synonyms: 2pri, D6G, 2-DEOXY-GLUCOSE-6-PHOSPHATE

Ferraris, A.M. et al., Gao, H. et al., Ferraris, A.M. et al., Guionie, O. et al., Ferraris, A.M. et al.

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High impact information on D6G

Enzymatic mosaicism in hemopoietic and nonhemopoietic cells was evaluated with the 2-deoxy glucose 6-phosphate technique [1].
2-deoxy-glucose-6-phosphate utilization in the study of glucose-6-phosphate dehydrogenase mosaicism [2].
The different utilization of 2-deoxy-glucose-6-phosphate (2dG6P), an analog of the normal substrate, by the normal enzyme and the Mediterranean variant, allows a convenient determination of the degree of mosaicism in mononuclear cells from heterozygotes [2].
G6PC3 preferentially hydrolyzed other substrates including pNPP and 2-deoxy-glucose-6-phosphate compared to the liver enzyme [3].
In the assay described herein, the product, glucose 6-phosphate was directly monitored by ion trap mass spectrometry and quantified using an internal standard, 2 deoxy-glucose 6-phosphate [4].

Gene context of D6G

G6PD mosaicism was assessed by the different rate of utilization of 2-deoxy-glucose-6-phosphate (2dG6P) by normal and Mediterranean variants of G6PD [5].

References

A case of ataxia telangiectasia with unbalanced glucose 6-phosphate dehydrogenase mosaicism in the granulocytic/monocytic lineages. Ferraris, A.M., Melani, C., Canepa, L., Meloni, T., Forteleoni, G., Gaetani, G.F. Am. J. Hum. Genet. (1987) [Pubmed]
2-deoxy-glucose-6-phosphate utilization in the study of glucose-6-phosphate dehydrogenase mosaicism. Ferraris, A.M., Giuntini, P., Galiano, S., Gaetani, G.F. Am. J. Hum. Genet. (1981) [Pubmed]
Identification and characterisation of a new human glucose-6-phosphatase isoform. Guionie, O., Clottes, E., Stafford, K., Burchell, A. FEBS Lett. (2003) [Pubmed]
Multiplex inhibitor screening and kinetic constant determinations for yeast hexokinase using mass spectrometry based assays. Gao, H., Leary, J.A. J. Am. Soc. Mass Spectrom. (2003) [Pubmed]
Reexpression of normal stem cells in erythroleukemia during remission. Ferraris, A.M., Canepa, L., Mareni, C., Baule, G., Meloni, T., Salvidio, E., Forteleoni, G., Gaetani, G.F. Blood (1983) [Pubmed]

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