The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
Chemical Compound Review

SureCN7420909     benzylN-[(1S,2S)-1-[[(2S)- 4,4-difluoro-3...

Synonyms: AC1L9QO4, 134450-35-4
 
 
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.
 

Disease relevance of AIDS-002713

  • The structure of the HIV-1 protease in complex with a pseudo-C2 symmetric inhibitor, which contains a central difluoroketone motif, has been determined with X-ray diffraction data extending to 1.7 A resolution [1].
 

High impact information on AIDS-002713

  • Difluoroketone aspartyl protease transition state analogue MW167 was relatively selective for presenilinase (IC50 < 1 microM) over gamma-secretase (IC50-16 microM) [2].
  • Noncovalent complexes between HLE and either the tight-binding secretory leucoprotease inhibitor (SLPI) or a slow tight-binding peptide difluoroketone inhibitor were not observed by ESI-MS [3].
  • A series of primate renin inhibitors containing difluorocarbinol and difluoroketone groups at the P1-P1' position have been synthesized and studied both in vitro and in vivo [4].

References

  1. Inhibition and catalytic mechanism of HIV-1 aspartic protease. Silva, A.M., Cachau, R.E., Sham, H.L., Erickson, J.W. J. Mol. Biol. (1996) [Pubmed]
  2. Presenilin endoproteolysis mediated by an aspartyl protease activity pharmacologically distinct from gamma-secretase. Campbell, W.A., Reed, M.L., Strahle, J., Wolfe, M.S., Xia, W. J. Neurochem. (2003) [Pubmed]
  3. Electrospray ionization mass spectrometry as a mechanistic tool: mass of human leucocyte elastase and a beta-lactam-derived E-I complex. Knight, W.B., Swiderek, K.M., Sakuma, T., Calaycay, J., Shively, J.E., Lee, T.D., Covey, T.R., Shushan, B., Green, B.G., Chabin, R. Biochemistry (1993) [Pubmed]
  4. Design and synthesis of potent, selective, and orally active fluorine-containing renin inhibitors. Doherty, A.M., Sircar, I., Kornberg, B.E., Quin, J., Winters, R.T., Kaltenbronn, J.S., Taylor, M.D., Batley, B.L., Rapundalo, S.R., Ryan, M.J. J. Med. Chem. (1992) [Pubmed]
 
WikiGenes - Universities