Gene Review:
ELANE - elastase, neutrophil expressed
Homo sapiens
Synonyms:
Bone marrow serine protease, ELA2, Elastase-2, GE, HLE, ...
Bellanné-Chantelot,
Clauin,
Leblanc,
Cassinat,
Rodrigues-Lima,
Beaufils,
Vaury,
Barkaoui,
Fenneteau,
Maier-Redelsperger,
Chomienne,
Donadieu,
Horwitz,
Benson,
Person,
Aprikyan,
Dale,
Preston,
Zarella,
Pendergraft,
Rudolph,
Yang,
Sekura,
Jennette,
Falk,
Le-Barillec,
Si-Tahar,
Balloy,
Chignard,
Dale,
Person,
Bolyard,
Aprikyan,
Bos,
Bonilla,
Boxer,
Kannourakis,
Zeidler,
Welte,
Benson,
Horwitz,
Yang,
Bamlet,
Sun,
Ebbert,
Aubry,
Krowka,
Taylor,
Marks,
Deschamps,
Swensen,
Wieben,
Cunningham,
Melton,
de Andrade,
Ancliff,
Gale,
Liesner,
Hann,
Linch,
Hess,
Sadallah,
Hefti,
Landmann,
Schifferli,
- Mutations in proto-oncogene GFI1 cause human neutropenia and target ELA2. Person, R.E., Li, F.Q., Duan, Z., Benson, K.F., Wechsler, J., Papadaki, H.A., Eliopoulos, G., Kaufman, C., Bertolone, S.J., Nakamoto, B., Papayannopoulou, T., Grimes, H.L., Horwitz, M. Nat. Genet. (2003)
- Mutations in the ELA2 gene correlate with more severe expression of neutropenia: a study of 81 patients from the French Neutropenia Register. Bellanné-Chantelot, C., Clauin, S., Leblanc, T., Cassinat, B., Rodrigues-Lima, F., Beaufils, S., Vaury, C., Barkaoui, M., Fenneteau, O., Maier-Redelsperger, M., Chomienne, C., Donadieu, J. Blood (2004)
- Alpha1-antitrypsin and neutrophil elastase imbalance and lung cancer risk. Yang, P., Bamlet, W.R., Sun, Z., Ebbert, J.O., Aubry, M.C., Krowka, M.J., Taylor, W.R., Marks, R.S., Deschamps, C., Swensen, S.J., Wieben, E.D., Cunningham, J.M., Melton, L.J., de Andrade, M. Chest (2005)
- Neutrophil elastase in respiratory epithelial lining fluid of individuals with cystic fibrosis induces interleukin-8 gene expression in a human bronchial epithelial cell line. Nakamura, H., Yoshimura, K., McElvaney, N.G., Crystal, R.G. J. Clin. Invest. (1992)
- Protease-antiprotease imbalance in the lungs of children with cystic fibrosis. Birrer, P., McElvaney, N.G., Rüdeberg, A., Sommer, C.W., Liechti-Gallati, S., Kraemer, R., Hubbard, R., Crystal, R.G. Am. J. Respir. Crit. Care Med. (1994)
- High molecular weight neurofilament proteins are physiological substrates of adduction by the lipid peroxidation product hydroxynonenal. Wataya, T., Nunomura, A., Smith, M.A., Siedlak, S.L., Harris, P.L., Shimohama, S., Szweda, L.I., Kaminski, M.A., Avila, J., Price, D.L., Cleveland, D.W., Sayre, L.M., Perry, G. J. Biol. Chem. (2002)
- 4-hydroxy-2-nonenal pyrrole adducts in human neurodegenerative disease. Montine, K.S., Kim, P.J., Olson, S.J., Markesbery, W.R., Montine, T.J. J. Neuropathol. Exp. Neurol. (1997)
- Polymorphonuclear (PMN) elastase levels in depressive disorders. Değer, O., Bekaroğlu, M., Orem, A., Orem, S., Uluutku, N., Soylu, C. Biol. Psychiatry (1996)
- Efficacy and safety during long-term treatment of primary monosymptomatic nocturnal enuresis with desmopressin. Swedish Enuresis Trial Group. Tullus, K., Bergström, R., Fosdal, I., Winnergård, I., Hjälmås, K. Acta Paediatr. (1999)
- Effects of antidepressant treatments on polymorphonuclear elastase levels in patients with depression. Bekaroğlu, M., Değer, O., Karahan, S.C., Bilici, M., Soylu, C., Orem, A. Journal of affective disorders. (2000)
- Mutations associated with neutropenia in dogs and humans disrupt intracellular transport of neutrophil elastase. Benson, K.F., Li, F.Q., Person, R.E., Albani, D., Duan, Z., Wechsler, J., Meade-White, K., Williams, K., Acland, G.M., Niemeyer, G., Lothrop, C.D., Horwitz, M. Nat. Genet. (2003)
- Mutations in ELA2, encoding neutrophil elastase, define a 21-day biological clock in cyclic haematopoiesis. Horwitz, M., Benson, K.F., Person, R.E., Aprikyan, A.G., Dale, D.C. Nat. Genet. (1999)
- A novel notch protein, N2N, targeted by neutrophil elastase and implicated in hereditary neutropenia. Duan, Z., Li, F.Q., Wechsler, J., Meade-White, K., Williams, K., Benson, K.F., Horwitz, M. Mol. Cell. Biol. (2004)
- Antineutrophil cytoplasmic antibodies reacting with human neutrophil elastase as a diagnostic marker for cocaine-induced midline destructive lesions but not autoimmune vasculitis. Wiesner, O., Russell, K.A., Lee, A.S., Jenne, D.E., Trimarchi, M., Gregorini, G., Specks, U. Arthritis Rheum. (2004)
- Elevated levels of matrix metalloproteinases in bronchoalveolar lavage fluid of emphysematous patients. Finlay, G.A., Russell, K.J., McMahon, K.J., D'arcy, E.M., Masterson, J.B., FitzGerald, M.X., O'Connor, C.M. Thorax (1997)
- Clinical and immunoregulatory effects of roxithromycin therapy for chronic respiratory tract infection. Nakamura, H., Fujishima, S., Inoue, T., Ohkubo, Y., Soejima, K., Waki, Y., Mori, M., Urano, T., Sakamaki, F., Tasaka, S., Ishizaka, A., Kanazawa, M., Yamaguchi, K. Eur. Respir. J. (1999)
- A neutrophil elastase inhibitor, sivelestat, ameliorates lung injury after hemorrhagic shock in rats. Toda, Y., Takahashi, T., Maeshima, K., Shimizu, H., Inoue, K., Morimatsu, H., Omori, E., Takeuchi, M., Akagi, R., Morita, K. Int. J. Mol. Med. (2007)
- Mutations in the ELA2 gene encoding neutrophil elastase are present in most patients with sporadic severe congenital neutropenia but only in some patients with the familial form of the disease. Ancliff, P.J., Gale, R.E., Liesner, R., Hann, I.M., Linch, D.C. Blood (2001)
- Changes in chromatin organization at the neutrophil elastase locus associated with myeloid cell differentiation. Wong, E.T., Jenne, D.E., Zimmer, M., Porter, S.D., Gilks, C.B. Blood (1999)
- Congenital and acquired neutropenia. Berliner, N., Horwitz, M., Loughran, T.P. Hematology / the Education Program of the American Society of Hematology. American Society of Hematology. Education Program. (2004)
- Mutations in the gene encoding neutrophil elastase in congenital and cyclic neutropenia. Dale, D.C., Person, R.E., Bolyard, A.A., Aprikyan, A.G., Bos, C., Bonilla, M.A., Boxer, L.A., Kannourakis, G., Zeidler, C., Welte, K., Benson, K.F., Horwitz, M. Blood (2000)
- Elastase and cathepsin G of human monocytes. Quantification of cellular content, release in response to stimuli, and heterogeneity in elastase-mediated proteolytic activity. Campbell, E.J., Silverman, E.K., Campbell, M.A. J. Immunol. (1989)
- Adenoviral gene delivery of elafin and secretory leukocyte protease inhibitor attenuates NF-kappa B-dependent inflammatory responses of human endothelial cells and macrophages to atherogenic stimuli. Henriksen, P.A., Hitt, M., Xing, Z., Wang, J., Haslett, C., Riemersma, R.A., Webb, D.J., Kotelevtsev, Y.V., Sallenave, J.M. J. Immunol. (2004)
- Three human elastase-like genes coordinately expressed in the myelomonocyte lineage are organized as a single genetic locus on 19pter. Zimmer, M., Medcalf, R.L., Fink, T.M., Mattmann, C., Lichter, P., Jenne, D.E. Proc. Natl. Acad. Sci. U.S.A. (1992)
- Specific inhibition of thrombin-induced cell activation by the neutrophil proteinases elastase, cathepsin G, and proteinase 3: evidence for distinct cleavage sites within the aminoterminal domain of the thrombin receptor. Renesto, P., Si-Tahar, M., Moniatte, M., Balloy, V., Van Dorsselaer, A., Pidard, D., Chignard, M. Blood (1997)
- Thrombospondin is a tight-binding competitive inhibitor of neutrophil elastase. Hogg, P.J., Owensby, D.A., Mosher, D.F., Misenheimer, T.M., Chesterman, C.N. J. Biol. Chem. (1993)
- Neutrophil serine proteinases activate human nonepithelial cells to produce inflammatory cytokines through protease-activated receptor 2. Uehara, A., Muramoto, K., Takada, H., Sugawara, S. J. Immunol. (2003)
- Human neutrophil elastase induces hypersecretion of mucin from well-differentiated human bronchial epithelial cells in vitro via a protein kinase C{delta}-mediated mechanism. Park, J.A., He, F., Martin, L.D., Li, Y., Chorley, B.N., Adler, K.B. Am. J. Pathol. (2005)
- Modulation of elastase binding to elastin by human alveolar macrophage-derived lipids. Fujita, J., Sköld, C.M., Daughton, D.M., Ertl, R.F., Takahara, J., Rennard, S.I. Am. J. Respir. Crit. Care Med. (1999)
- Therapeutic level of functional human alpha 1 antitrypsin (hAAT) secreted from murine muscle transduced by adeno-associated virus (rAAV1) vector. Lu, Y., Choi, Y.K., Campbell-Thompson, M., Li, C., Tang, Q., Crawford, J.M., Flotte, T.R., Song, S. The journal of gene medicine. (2006)
- Neutrophil elastase stimulates MUC1 gene expression through increased Sp1 binding to the MUC1 promoter. Kuwahara, I., Lillehoj, E.P., Hisatsune, A., Lu, W., Isohama, Y., Miyata, T., Kim, K.C. Am. J. Physiol. Lung Cell Mol. Physiol. (2005)
- Electrospray ionization mass spectrometry as a mechanistic tool: mass of human leucocyte elastase and a beta-lactam-derived E-I complex. Knight, W.B., Swiderek, K.M., Sakuma, T., Calaycay, J., Shively, J.E., Lee, T.D., Covey, T.R., Shushan, B., Green, B.G., Chabin, R. Biochemistry (1993)
- Susceptibility of baboon aorta elastin to proteolysis. Desfontaines, L., Hornebeck, W., Wei, S.M., Robert, L., Lafuma, C. Biol. Chem. Hoppe-Seyler (1990)
- The cleavage and inactivation of plasminogen activator inhibitor type 1 by neutrophil elastase: the evaluation of its physiologic relevance in fibrinolysis. Wu, K., Urano, T., Ihara, H., Takada, Y., Fujie, M., Shikimori, M., Hashimoto, K., Takada, A. Blood (1995)
- Effect of leukocyte proteinases on tissue factor pathway inhibitor. Petersen, L.C., Bjørn, S.E., Nordfang, O. Thromb. Haemost. (1992)
- Thromsbospondin-1 binds to the heavy chain of elastase activated coagulation factor V (FVaHNE) and enhances thrombin generation on the surface of a promyelocytic cell line. Isordia-Salas, I., Manns, J.M., Sainz, I., Parekh, H., DeLa Cadena, R.A. Thromb. Res. (2005)
- Ectosomes released by human neutrophils are specialized functional units. Hess, C., Sadallah, S., Hefti, A., Landmann, R., Schifferli, J.A. J. Immunol. (1999)
- Neutrophil elastase induces MUC5AC mucin production in human airway epithelial cells via a cascade involving protein kinase C, reactive oxygen species, and TNF-alpha-converting enzyme. Shao, M.X., Nadel, J.A. J. Immunol. (2005)
- Neutrophil elastase-initiated EGFR/MEK/ERK signaling counteracts stabilizing effect of autocrine TGF-beta on tropoelastin mRNA in lung fibroblasts. DiCamillo, S.J., Yang, S., Panchenko, M.V., Toselli, P.A., Naggar, E.F., Rich, C.B., Stone, P.J., Nugent, M.A., Panchenko, M.P. Am. J. Physiol. Lung Cell Mol. Physiol. (2006)
- Utilization of the 1,2,5-thiadiazolidin-3-one 1,1 dioxide scaffold in the design of potent inhibitors of serine proteases: SAR studies using carboxylates. Kuang, R., Epp, J.B., Ruan, S., Chong, L.S., Venkataraman, R., Tu, J., He, S., Truong, T.M., Groutas, W.C. Bioorg. Med. Chem. (2000)
- Interleukin-8 up-regulation by neutrophil elastase is mediated by MyD88/IRAK/TRAF-6 in human bronchial epithelium. Walsh, D.E., Greene, C.M., Carroll, T.P., Taggart, C.C., Gallagher, P.M., O'Neill, S.J., McElvaney, N.G. J. Biol. Chem. (2001)
- Proteolysis of monocyte CD14 by human leukocyte elastase inhibits lipopolysaccharide-mediated cell activation. Le-Barillec, K., Si-Tahar, M., Balloy, V., Chignard, M. J. Clin. Invest. (1999)
- Converting enzyme-independent release of tumor necrosis factor alpha and IL-1beta from a stimulated human monocytic cell line in the presence of activated neutrophils or purified proteinase 3. Coeshott, C., Ohnemus, C., Pilyavskaya, A., Ross, S., Wieczorek, M., Kroona, H., Leimer, A.H., Cheronis, J. Proc. Natl. Acad. Sci. U.S.A. (1999)
- Neutrophil elastase enzymatically antagonizes the in vitro action of G-CSF: implications for the regulation of granulopoiesis. El Ouriaghli, F., Fujiwara, H., Melenhorst, J.J., Sconocchia, G., Hensel, N., Barrett, A.J. Blood (2003)
- Novel effects of neutrophil-derived proteinase 3 and elastase on the vascular endothelium involve in vivo cleavage of NF-kappaB and proapoptotic changes in JNK, ERK, and p38 MAPK signaling pathways. Preston, G.A., Zarella, C.S., Pendergraft, W.F., Rudolph, E.H., Yang, J.J., Sekura, S.B., Jennette, J.C., Falk, R.J. J. Am. Soc. Nephrol. (2002)