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Chemical Compound Review

BCH-1081     4-amino-5-fluoro-1-[(2R,4R)- 2...

Synonyms: SureCN5607740, AC1L9S1L, (-)-dOTFC, (+/-)dOTFC, (-)-2'-Deoxy-3'-oxa-4'-thio-5-fluorocytidine
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Disease relevance of AIDS005503


High impact information on AIDS005503

  • Studies with mutated recombinant HXB2D virus confirmed the importance of the M184V mutation in conferring resistance to (-)dOTFC in MT-4 cells, although no difference in sensitivity was observed in primary cells [1].

Anatomical context of AIDS005503


Analytical, diagnostic and therapeutic context of AIDS005503

  • The D67G mutation was introduced into HXB2D by site-directed mutagenesis, and the data obtained confirmed the importance of this mutation in conferring resistance to both (+)dOTFC and (-)dOTFC [1].


  1. Selection and characterization of human immunodeficiency virus type 1 variants resistant to the (+) and (-) enantiomers of 2'-deoxy-3'-oxa-4'-thio-5-fluorocytidine. Richard, N., Salomon, H., Rando, R., Mansour, T., Bowlin, T.L., Wainberg, M.A. Antimicrob. Agents Chemother. (2000) [Pubmed]
  2. Selection of resistance-conferring mutations in HIV-1 by the nucleoside reverse transcriptase inhibitors (+/-)dOTC and (+/-)dOTFC. Richard, N., Salomon, H., Oliveira, M., Rando, R., Mansour, T., Gu, Z., Wainberg, M.A. Antivir. Chem. Chemother. (2000) [Pubmed]
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