Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Chemical Compound Review:

Cosmegen 2-amino-4,6-dimethyl-3-oxo- N,N'-bis[(3R,6S...

Synonyms: Actinomycin, DACTINOMYCIN, actinomycin D, UPCMLD-DP055, GNF-Pf-2290, ...

Pirson, I. et al., Seo, H.S. et al.

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High impact information on actinomycin D

E2-induced ER down-regulation was partly blocked by actinomycin D (AMD), okadaic acid (OK) and cycloheximide (CHX) when assessed by these 2 methods [1].
Using in vitro elongation of nascent transcripts to measure transcription and actinomycin D (AcD) chase experiments to study mRNA stability, we have shown that in the first phase cAMP releases a transcriptional elongation block [2].

References

Estrogenic and anti-estrogenic regulation of estrogen receptor in MCF-7 breast-cancer cells: comparison of immunocytochemical data with biochemical measurements. Seo, H.S., Larsimont, D., Querton, G., El Khissiin, A., Laios, I., Legros, N., Leclercq, G. Int. J. Cancer (1998) [Pubmed]
c-Myc expression is controlled by the mitogenic cAMP-cascade in thyrocytes. Pirson, I., Coulonval, K., Lamy, F., Dumont, J.E. J. Cell. Physiol. (1996) [Pubmed]

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