Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Chemical Compound Review:

AGN-PC-00JBGV [3,4-dihydroxy-5- (methylsulfanylmethyl)oxo...

Synonyms: AC1L19AP

Savarese, T.M. et al., Bumann, M. et al.

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Disease relevance of 1-PMTR

Recently, one of those latter proteins from Bacillus subtilis has been characterized as a 5-methylthioribose-1-phosphate isomerase, an enzyme of the methionine salvage pathway [1].

High impact information on 1-PMTR

5'-Deoxy-5'-methylthioadenosine phosphorylase (MTAPase) phosphorolyzes 5'-deoxy-5'-methylthioadenosine (MTA) generated during polyamine biosynthesis to adenine and 5-methylthioribose-1-phosphate [2].

References

Crystal structure of yeast Ypr118w, a methylthioribose-1-phosphate isomerase related to regulatory eIF2B subunits. Bumann, M., Djafarzadeh, S., Oberholzer, A.E., Bigler, P., Altmann, M., Trachsel, H., Baumann, U. J. Biol. Chem. (2004) [Pubmed]
5'-deoxy-5'-methylthioadenosine phosphorylase--IV. Biological activity of 2-fluoroadenine-substituted 5'-deoxy-5'-methylthioadenosine analogs. Savarese, T.M., Cannistra, A.J., Parks, R.E., Secrist, J.A., Shortnacy, A.T., Montgomery, J.A. Biochem. Pharmacol. (1987) [Pubmed]

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