Gene Review:
MTAP - methylthioadenosine phosphorylase
Homo sapiens
Synonyms:
5'-methylthioadenosine phosphorylase, BDMF, DMSFH, DMSMFH, HEL-249, ...
- Genomic cloning of methylthioadenosine phosphorylase: a purine metabolic enzyme deficient in multiple different cancers. Nobori, T., Takabayashi, K., Tran, P., Orvis, L., Batova, A., Yu, A.L., Carson, D.A. Proc. Natl. Acad. Sci. U.S.A. (1996)
- Frequent deletion in the methylthioadenosine phosphorylase gene in T-cell acute lymphoblastic leukemia: strategies for enzyme-targeted therapy. Batova, A., Diccianni, M.B., Nobori, T., Vu, T., Yu, J., Bridgeman, L., Yu, A.L. Blood (1996)
- Methylthioadenosine phosphorylase, a gene frequently codeleted with p16(cdkN2a/ARF), acts as a tumor suppressor in a breast cancer cell line. Christopher, S.A., Diegelman, P., Porter, C.W., Kruger, W.D. Cancer Res. (2002)
- Lack of methylthioadenosine phosphorylase expression in mantle cell lymphoma is associated with shorter survival: implications for a potential targeted therapy. Marcé, S., Balagué, O., Colomo, L., Martinez, A., Höller, S., Villamor, N., Bosch, F., Ott, G., Rosenwald, A., Leoni, L., Esteller, M., Fraga, M.F., Montserrat, E., Colomer, D., Campo, E. Clin. Cancer Res. (2006)
- Concordant loss of MTAP and p16/CDKN2A expression in gastroesophageal carcinogenesis: evidence of homozygous deletion in esophageal noninvasive precursor lesions and therapeutic implications. Powell, E.L., Leoni, L.M., Canto, M.I., Forastiere, A.A., Iocobuzio-Donahue, C.A., Wang, J.S., Maitra, A., Montgomery, E. Am. J. Surg. Pathol. (2005)
- EFA (9-beta-D-erythrofuranosyladenine) is an effective salvage agent for methylthioadenosine phosphorylase-selective therapy of T-cell acute lymphoblastic leukemia with L-alanosine. Batova, A., Cottam, H., Yu, J., Diccianni, M.B., Carrera, C.J., Yu, A.L. Blood (2006)
- Methylthioadenosine phosphorylase as target for chemoselective treatment of T-cell acute lymphoblastic leukemic cells. Efferth, T., Miyachi, H., Drexler, H.G., Gebhart, E. Blood Cells Mol. Dis. (2002)
- Construction of a 2.8-megabase yeast artificial chromosome contig and cloning of the human methylthioadenosine phosphorylase gene from the tumor suppressor region on 9p21. Olopade, O.I., Pomykala, H.M., Hagos, F., Sveen, L.W., Espinosa, R., Dreyling, M.H., Gursky, S., Stadler, W.M., Le Beau, M.M., Bohlander, S.K. Proc. Natl. Acad. Sci. U.S.A. (1995)
- Refined mapping of genomic rearrangements involving the short arm of chromosome 9 in acute lymphoblastic leukemias and other hematologic malignancies. Dreyling, M.H., Bohlander, S.K., Le Beau, M.M., Olopade, O.I. Blood (1995)
- Gene deletion chemoselectivity: codeletion of the genes for p16(INK4), methylthioadenosine phosphorylase, and the alpha- and beta-interferons in human pancreatic cell carcinoma lines and its implications for chemotherapy. Chen, Z.H., Zhang, H., Savarese, T.M. Cancer Res. (1996)
- Homozygous deletion of the MTAP gene in invasive adenocarcinoma of the pancreas and in periampullary cancer: a potential new target for therapy. Hustinx, S.R., Hruban, R.H., Leoni, L.M., Iacobuzio-Donahue, C., Cameron, J.L., Yeo, C.J., Brown, P.N., Argani, P., Ashfaq, R., Fukushima, N., Goggins, M., Kern, S.E., Maitra, A. Cancer Biol. Ther. (2005)
- Promoter-hypermethylation is causing functional relevant downregulation of methylthioadenosine phosphorylase (MTAP) expression in hepatocellular carcinoma. Hellerbrand, C., Mühlbauer, M., Wallner, S., Schuierer, M., Behrmann, I., Bataille, F., Weiss, T., Schölmerich, J., Bosserhoff, A.K. Carcinogenesis (2006)
- Strong expression of methylthioadenosine phosphorylase (MTAP) in human colon carcinoma cells is regulated by TCF1/[beta]-catenin. Bataille, F., Rogler, G., Modes, K., Poser, I., Schuierer, M., Dietmaier, W., Ruemmele, P., Mühlbauer, M., Wallner, S., Hellerbrand, C., Bosserhoff, A.K. Lab. Invest. (2005)
- Use of alanosine as a methylthioadenosine phosphorylase-selective therapy for T-cell acute lymphoblastic leukemia in vitro. Batova, A., Diccianni, M.B., Omura-Minamisawa, M., Yu, J., Carrera, C.J., Bridgeman, L.J., Kung, F.H., Pullen, J., Amylon, M.D., Yu, A.L. Cancer Res. (1999)
- Molecular genetic alterations in radiation-induced astrocytomas. Brat, D.J., James, C.D., Jedlicka, A.E., Connolly, D.C., Chang, E., Castellani, R.J., Schmid, M., Schiller, M., Carson, D.A., Burger, P.C. Am. J. Pathol. (1999)
- The prognostic significance of CDKN2A, CDKN2B and MTAP inactivation in B-lineage acute lymphoblastic leukemia of childhood. Results of the EORTC studies 58881 and 58951. Mirebeau, D., Acquaviva, C., Suciu, S., Bertin, R., Dastugue, N., Robert, A., Boutard, P., Méchinaud, F., Plouvier, E., Otten, J., Vilmer, E., Cavé, H. Haematologica (2006)
- Detection of gene amplification and deletion in high-grade gliomas using a genome DNA microarray (GenoSensor Array 300). Sasaki, T., Arai, H., Beppu, T., Ogasawara, K. Brain tumor pathology. (2003)
- Loss of methylthioadenosine phosphorylase and elevated ornithine decarboxylase is common in pancreatic cancer. Subhi, A.L., Tang, B., Balsara, B.R., Altomare, D.A., Testa, J.R., Cooper, H.S., Hoffman, J.P., Meropol, N.J., Kruger, W.D. Clin. Cancer Res. (2004)
- A methylthioadenosine phosphorylase (MTAP) fusion transcript identifies a new gene on chromosome 9p21 that is frequently deleted in cancer. Schmid, M., Sen, M., Rosenbach, M.D., Carrera, C.J., Friedman, H., Carson, D.A. Oncogene (2000)
- Methylthioadenosine phosphorylase regulates ornithine decarboxylase by production of downstream metabolites. Subhi, A.L., Diegelman, P., Porter, C.W., Tang, B., Lu, Z.J., Markham, G.D., Kruger, W.D. J. Biol. Chem. (2003)