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Chemical Compound Review

Lopac-I-114     N-(2,6-dichloro-4-iodo- phenyl)-4,5-dihydro...

Synonyms: CHEMBL360803, SureCN563884, SureCN10606433, CHEBI:408800, CCG-204750, ...
 
 
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Disease relevance of Lopac-I-114

 

High impact information on Lopac-I-114

  • Therefore, p-iodoclonidine is an agonist in a cell culture model system of the neuronal alpha 2-adrenergic receptor. p-[125I]Iodoclonidine binding to membranes were measured using various regions of the rat brain [1].
  • Receptor binding studies with the alpha 2-agonist radioligand [125I] p-iodoclonidine ([125I]PIC) in rabbit ciliary body membranes indicate that the alpha 2-receptor subtype is alpha 2A [2].

References

  1. p-[125I]iodoclonidine, a novel radiolabeled agonist for studying central alpha 2-adrenergic receptors. Baron, B.M., Siegel, B.W. Mol. Pharmacol. (1990) [Pubmed]
  2. Ocular alpha 2-receptor subclasses and antiglaucoma efficacy. Jin, Y., Gooding, J.R., Yorio, T. Journal of ocular pharmacology. (1994) [Pubmed]
 
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