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Chemical Compound Review

AG-K-29423     1-cyclopropyl-8- (difluoromethoxy)-7-(1...

Synonyms: SureCN2897686, CTK7B7265, AC1LA1OP, Des-fluoro(6) quinolone
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Disease relevance of AIDS-094950


High impact information on AIDS-094950


Chemical compound and disease context of AIDS-094950


  1. Molecular Characteristics and In Vitro Susceptibility to Antimicrobial Agents, Including the Des-Fluoro(6) Quinolone DX-619, of Panton-Valentine Leucocidin-Positive Methicillin-Resistant Staphylococcus aureus Isolates from the Community and Hospitals. Yamamoto, T., Dohmae, S., Saito, K., Otsuka, T., Takano, T., Chiba, M., Fujikawa, K., Tanaka, M. Antimicrob. Agents Chemother. (2006) [Pubmed]
  2. In vivo efficacies and pharmacokinetics of DX-619, a novel des-fluoro(6) quinolone, against Streptococcus pneumoniae in a mouse lung infection model. Fukuda, Y., Yanagihara, K., Ohno, H., Higashiyama, Y., Miyazaki, Y., Tsukamoto, K., Hirakata, Y., Tomono, K., Mizuta, Y., Tashiro, T., Kohno, S. Antimicrob. Agents Chemother. (2006) [Pubmed]
  3. In vitro activities of a new des-fluoro(6) quinolone, garenoxacin, against clinical anaerobic bacteria. Liebetrau, A., Rodloff, A.C., Behra-Miellet, J., Dubreuil, L. Antimicrob. Agents Chemother. (2003) [Pubmed]
  4. Synergistic activity of the novel des-fluoro(6) quinolone, garenoxacin (BMS-284756), in combination with other antimicrobial agents against Pseudomonas aeruginosa and related species. Fung-Tomc, J.C., Gradelski, E., Valera, L., Huczko, E., Bonner, D.P. Int. J. Antimicrob. Agents (2002) [Pubmed]
  5. Comparative killing kinetics of the novel des-fluoro(6) quinolone BMS-284756, fluoroquinolones, vancomycin and beta-lactams. Gradelski, E., Valera, L., Kolek, B., Bonner, D., Fung-Tomc, J. Int. J. Antimicrob. Agents (2001) [Pubmed]
  6. DX-619, a novel des-fluoro(6) quinolone manifesting low frequency of selection of resistant Staphylococcus aureus mutants: quinolone resistance beyond modification of type II topoisomerases. Strahilevitz, J., Truong-Bolduc, Q.C., Hooper, D.C. Antimicrob. Agents Chemother. (2005) [Pubmed]
  7. The in vitro activity of BMS-284756, a new des-fluorinated quinolone. Weller, T.M., Andrews, J.M., Jevons, G., Wise, R. J. Antimicrob. Chemother. (2002) [Pubmed]
  8. Activity of BMS-284756, a novel des-fluoro(6) quinolone, against Staphylococcus aureus, including contributions of mutations to quinolone resistance. Low, D.E., Muller, M., Duncan, C.L., Willey, B.M., de Azavedo, J.C., McGeer, A., Kreiswirth, B.N., Pong-Porter, S., Bast, D.J. Antimicrob. Agents Chemother. (2002) [Pubmed]
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