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Chemical Compound Review:

AC1LA62O [3-[[5-(6-aminopurin-9-yl)-3- hydroxy...

Synonyms: 5'-TA-3'

Mayer, K.M. et al., Tenzen, T. et al., Warmlander, S. et al., Duharcourt, S. et al., Ku, M. et al., et al.

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Disease relevance of 5'-TA-3'

A composite transposon, Tn4731, associated with IS630 has been shown to transpose preferentially to 5'-TA-3' sequences that are located at two sites in a rho-dependent transcription terminator in plasmid ColE1 in Escherichia coli (T. Tenzen, S. Matsutani, and E. Ohtsubo, J. Bacteriol. 172:3830-3836, 1990) [1].

High impact information on 5'-TA-3'

Each internal eliminated sequence (IES) is bounded by 5'-TA-3' dinucleotide repeats, a feature common to some classes of DNA transposons [2].
No absolutely conserved sequence element, other than flanking 5'-TA-3' direct repeats, has been identified among sequenced IESs; the mechanisms of their specific recognition and precise elimination are unknown [3].
Sequences of four or more AT base pairs without a 5'-TA-3' step, so-called A-tracts, influence the global properties of DNA by causing curvature of the helix axis if phased with the helical repeat and also influence nucleosome packaging [4].
Paramecium tetraurelia internal eliminated sequences (IESs) are invariably flanked by a 5'-TA-3' dinucleotide sequence that is part of a larger 8-bp terminal inverted-repeat consensus sequence [5].
A mutation in the flanking 5'-TA-3' dinucleotide prevents excision of an internal eliminated sequence from the Paramecium tetraurelia genome [5].

Gene context of 5'-TA-3'

IES1 is flanked by a pair of hepta-nucleotide 5'-AAATTTT-3' direct repeats, and IES2 is flanked by 5'-TA-3' direct repeats [6].

References

Preferential transposition of an IS630-associated composite transposon to TA in the 5'-CTAG-3' sequence. Tenzen, T., Ohtsubo, E. J. Bacteriol. (1991) [Pubmed]
Developmentally regulated excision of a 28-base-pair sequence from the Paramecium genome requires flanking DNA. Ku, M., Mayer, K., Forney, J.D. Mol. Cell. Biol. (2000) [Pubmed]
Homology-dependent maternal inhibition of developmental excision of internal eliminated sequences in Paramecium tetraurelia. Duharcourt, S., Keller, A.M., Meyer, E. Mol. Cell. Biol. (1998) [Pubmed]
The influence of the thymine C5 methyl group on spontaneous base pair breathing in DNA. Warmlander, S., Sponer, J.E., Sponer, J., Leijon, M. J. Biol. Chem. (2002) [Pubmed]
A mutation in the flanking 5'-TA-3' dinucleotide prevents excision of an internal eliminated sequence from the Paramecium tetraurelia genome. Mayer, K.M., Forney, J.D. Genetics (1999) [Pubmed]
Cloning and sequence analysis of the micronuclear and macronuclear gene encoding Rab protein of Euplotes octocarinatus. Wang, W., Zhi, H., Chai, B., Liang, A. Biosci. Biotechnol. Biochem. (2005) [Pubmed]

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