Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Chemical Compound Review:

Medorubicin (7S,9R)-7-[(2S,4S,5S,6S)-4- amino-5-hydroxy...

Synonyms: AC1LAYI0, CHEMBL458336, SureCN628909, NSC256438, 4-DMA, ...

Di Marco, A. et al., Formelli, F. et al.

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Disease relevance of Medorubicin

At the optimal dose, 4-demethoxyadriamycin displayed antitumor activity similar to that of adriamycin in solid Sarcoma 180 (S180), L1210, P388, and Gross leukemias, and mammary carcinoma, while it did not markedly inhibit the growth of Moloney sarcoma virus-induced sarcoma in mice treated before the virus infection [1].

High impact information on Medorubicin

The tissue distribution of 4-demethoxydaunorubicin and 4-demethoxydoxorubicin was studied in comparison with that of their patient compounds, daunorubicin and doxorubicin, in mice bearing transplanted tumors [2].

References

Synthesis and antitumor activity of 4-demethoxyadriamycin and 4-demethoxy-4' -epiadriamycin. Di Marco, A., Casazza, A.M., Giuliani, F., Pratesi, G., Arcamone, F., Bernardi, L., Franchi, G., Giardino, P., Patelli, B., Penco, S. Cancer treatment reports. (1978) [Pubmed]
Fluorescence assay of tissue distribution of 4-demethoxydaunorubicin and 4-demethoxydoxorubicin in mice bearing solid tumors. Formelli, F., Casazza, A.M., Di Marco, A., Mariani, A., Pollini, C. Cancer Chemother. Pharmacol. (1979) [Pubmed]

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