Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Chemical Compound Review:

methyl)- N'-[(2S,3S)-4-[(3S,4aS,8aR)- 3-(tert...

Synonyms: AC1LA6SK

Pooya, S. et al.

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Disease relevance of methyl)-

This link between methyl donor deficiency and epigenomic deregulations of energy metabolism opens new insights into the pathogenesis of fatty liver disease, in particular, in relation to the fetal programming hypothesis [1].

References

Methyl donor deficiency impairs fatty acid oxidation through PGC-1α hypomethylation and decreased ER-α, ERR-α, and HNF-4α in the rat liver. Pooya, S., Blaise, S., Moreno Garcia, M., Giudicelli, J., Alberto, J.M., Guéant-Rodriguez, R.M., Jeannesson, E., Gueguen, N., Bressenot, A., Nicolas, B., Malthiery, Y., Daval, J.L., Peyrin-Biroulet, L., Bronowicki, J.P., Guéant, J.L. J. Hepatol. (2012) [Pubmed]

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