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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Chemical Compound Review: 

Iso-Olomoucine     2-[[6-(benzylamino)-7-methyl- purin-2...

Synonyms: AG-D-08780, CHEMBL1882973, ACMC-20enxw, SureCN12981789, CCG-100651, ...
 
 
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High impact information on Iso-Olomoucine

  • While an inactive stereoisomer, iso-olomoucine, was ineffective, two potent inhibitors, roscovitine and olomoucine, attenuated significantly the hyperphosphorylation of neurofilament, tau, and mitotic proteins, reduced the number of spheroids, modulated Purkinje neuron death, and ameliorated motor defects in npc mice [1].
  • Inhibition of Cdk5 with olomoucine decreased evoked norepinephrine secretion from chromaffin cells, an effect not observed with the inactive analogue iso-olomoucine [2].
  • We also found that the more specific cdk inhibitor, roscovitine, was approximately 10-fold more effective in lengthening circadian period, while the inactive analogue, iso-olomoucine, was ineffective [3].

References

  1. Cyclin-dependent kinase inhibitors attenuate protein hyperphosphorylation, cytoskeletal lesion formation, and motor defects in Niemann-Pick Type C mice. Zhang, M., Li, J., Chakrabarty, P., Bu, B., Vincent, I. Am. J. Pathol. (2004) [Pubmed]
  2. Regulation of exocytosis by cyclin-dependent kinase 5 via phosphorylation of Munc18. Fletcher, A.I., Shuang, R., Giovannucci, D.R., Zhang, L., Bittner, M.A., Stuenkel, E.L. J. Biol. Chem. (1999) [Pubmed]
  3. The cyclin-dependent kinase (cdk) inhibitors, olomoucine and roscovitine, alter the expression of a molluscan circadian pacemaker. Krucher, N.A., Meijer, L., Roberts, M.H. Cell. Mol. Neurobiol. (1997) [Pubmed]
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