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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Chemical Compound Review: 

swainsonine     (1S,2R,8R,8aR)- 1,2,3,5,6,7,8,8a...

Synonyms: Tridolgosir, CHEMBL371197, SureCN765848, CHEBI:9367, BSPBio_001148, ...
 
 
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High impact information on swainsonine

  • To elucidate the role of N-linked glycans in triggering T-cell functions, the effects of the N-glycan processing inhibitors 1-deoxymannojirimycin (1-DMM) and swainsonine (SW) were investigated on signaling events and induction of apoptosis in galectin-1 (gal-1)-stimulated Jurkat T lymphocytes [1].
  • Although the level of infectious virus and syncytia formation was not significantly affected by SW-treatment, DMJ-treatment correlated with a one hundred-fold reduction in virus infectivity [2].
  • CONCLUSIONS: Subclinical intoxication with SW did not affect the pharmacokinetics of PAH [3].
  • However, DMN and SWS, inhibitors of mannosidase I and II, tested in parallel to CAS and ACE-M, exhibited no IC50 values [4].

References

  1. Effects of N-glycan processing inhibitors on signaling events and induction of apoptosis in galectin-1-stimulated Jurkat T lymphocytes. Walzel, H., Fahmi, A.A., Eldesouky, M.A., Abou-Eladab, E.F., Waitz, G., Brock, J., Tiedge, M. Glycobiology (2006) [Pubmed]
  2. Evidence that maturation of the N-linked glycans of the respiratory syncytial virus (RSV) glycoproteins is required for virus-mediated cell fusion: The effect of alpha-mannosidase inhibitors on RSV infectivity. McDonald, T.P., Jeffree, C.E., Li, P., Rixon, H.W., Brown, G., Aitken, J.D., MacLellan, K., Sugrue, R.J. Virology (2006) [Pubmed]
  3. Clearance of para-aminohippuric acid in wethers consuming locoweed. Strickland, J.R., Custis, M.A., Ashley, A.K., Smith, L.L., Klotz, J.L., Krehbiel, C.R. New Zealand veterinary journal. (2005) [Pubmed]
  4. Inhibition of AIDS virus replication by acemannan in vitro. Kahlon, J.B., Kemp, M.C., Carpenter, R.H., McAnalley, B.H., McDaniel, H.R., Shannon, W.M. Mol. Biother. (1991) [Pubmed]
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