Chemical Compound Review:
CHEMBL63139 (8R,8aR)-1,2,3,5,6,7,8,8a...
Synonyms:
CHEBI:202237, NSC614553, AC1L79LA, NCI60_004937, 72741-87-8
- Swainsonine inhibition of spontaneous metastasis. Newton, S.A., White, S.L., Humphries, M.J., Olden, K. J. Natl. Cancer Inst. (1989)
- Inhibition of human HT29 colon carcinoma growth in vitro and in vivo by swainsonine and human interferon-alpha 2. Dennis, J.W., Koch, K., Beckner, D. J. Natl. Cancer Inst. (1989)
- In vivo induction of gliadin-mediated enterocyte damage in rats by the mannosidase inhibitor, swainsonine: a possible animal model for celiac disease. Köttgen, E., Beiswenger, M., James, L.F., Bauer, C. Gastroenterology (1988)
- Ectopic dendrites occur only on cortical pyramidal cells containing elevated GM2 ganglioside in alpha-mannosidosis. Goodman, L.A., Livingston, P.O., Walkley, S.U. Proc. Natl. Acad. Sci. U.S.A. (1991)
- Apoptosis of T cells mediated by galectin-1. Perillo, N.L., Pace, K.E., Seilhamer, J.J., Baum, L.G. Nature (1995)
- A mannose receptor mediates mannosyl-rich glycoprotein-induced mitogenesis in bovine airway smooth muscle cells. Lew, D.B., Songu-Mize, E., Pontow, S.E., Stahl, P.D., Rattazzi, M.C. J. Clin. Invest. (1994)
- Protective effects of swainsonine on murine survival and bone marrow proliferation during cytotoxic chemotherapy. Oredipe, O.A., White, S.L., Grzegorzewski, K., Gause, B.L., Cha, J.K., Miles, V.A., Olden, K. J. Natl. Cancer Inst. (1991)
- Inhibition of experimental metastasis by castanospermine in mice: blockage of two distinct stages of tumor colonization by oligosaccharide processing inhibitors. Humphries, M.J., Matsumoto, K., White, S.L., Olden, K. Cancer Res. (1986)
- Effects of swainsonine and polyinosinic:polycytidylic acid on murine tumor cell growth and metastasis. Dennis, J.W. Cancer Res. (1986)
- The effects of processing inhibitors of N-linked oligosaccharides on the intracellular migration of glycoprotein E2 of mouse hepatitis virus and the maturation of coronavirus particles. Repp, R., Tamura, T., Boschek, C.B., Wege, H., Schwarz, R.T., Niemann, H. J. Biol. Chem. (1985)
- Reduced glycosylation of human cell lines increases susceptibility to CD4-independent infection by human immunodeficiency virus type 2 (LAV-2/B). Talbot, S.J., Weiss, R.A., Schulz, T.F. J. Virol. (1995)
- The mannosidase inhibitors 1-deoxymannojirimycin and swainsonine have no effect on the biosynthesis and infectivity of Rous sarcoma virus. Bosch, J.V., Tlusty, A., McDowell, W., Legler, G., Schwarz, R.T. Virology (1985)
- Saccharides mediate the attachment of rat macrophages to bone in vitro. Bar-Shavit, Z., Teitelbaum, S.L., Kahn, A.J. J. Clin. Invest. (1983)
- Inhibition of N-linked oligosaccharide trimming mannosidases blocks human B cell development. Tulp, A., Barnhoorn, M., Bause, E., Ploegh, H. EMBO J. (1986)
- Lysosomal delivery of the major myelin glycoprotein in the absence of myelin assembly: posttranslational regulation of the level of expression by Schwann cells. Brunden, K.R., Poduslo, J.F. J. Cell Biol. (1987)
- Reduced contact-inhibition and substratum adhesion in epithelial cells expressing GlcNAc-transferase V. Demetriou, M., Nabi, I.R., Coppolino, M., Dedhar, S., Dennis, J.W. J. Cell Biol. (1995)
- Functionally distinct roles for glycosylation of alpha and beta integrin chains in cell-matrix interactions. Chammas, R., Veiga, S.S., Travassos, L.R., Brentani, R.R. Proc. Natl. Acad. Sci. U.S.A. (1993)
- Tumor cell surface beta 1-4-linked galactose binds to lectin(s) on microvascular endothelial cells and contributes to organ colonization. Cornil, I., Kerbel, R.S., Dennis, J.W. J. Cell Biol. (1990)
- Effects of swainsonine on rat liver and kidney: biochemical and morphological studies. Novikoff, P.M., Touster, O., Novikoff, A.B., Tulsiani, D.P. J. Cell Biol. (1985)
- Swainsonine: an inhibitor of glycoprotein processing. Elbein, A.D., Solf, R., Dorling, P.R., Vosbeck, K. Proc. Natl. Acad. Sci. U.S.A. (1981)
- Glucocorticoids modulate macrophage surface oligosaccharides and their bone binding activity. Bar-Shavit, Z., Kahn, A.J., Pegg, L.E., Stone, K.R., Teitelbaum, S.L. J. Clin. Invest. (1984)
- Transformation by the v-fms oncogene product: role of glycosylational processing and cell surface expression. Nichols, E.J., Manger, R., Hakomori, S., Herscovics, A., Rohrschneider, L.R. Mol. Cell. Biol. (1985)
- Evidence that high mannose glycopeptides are able to functionally interact with recombinant tumor necrosis factor and recombinant interleukin 1. Muchmore, A., Decker, J., Shaw, A., Wingfield, P. Cancer Res. (1990)
- Augmentation of murine natural killer cell activity by swainsonine, a new antimetastatic immunomodulator. Humphries, M.J., Matsumoto, K., White, S.L., Molyneux, R.J., Olden, K. Cancer Res. (1988)
- Swainsonine and castanospermine blockade of mannose glycoprotein uptake by macrophages. Apparent inhibition of receptor-mediated endocytosis by endogenous ligands. Chung, K.N., Shepherd, V.L., Stahl, P.D. J. Biol. Chem. (1984)
- N-acetylglucosaminyltransferase V (Mgat5)-mediated N-glycosylation negatively regulates Th1 cytokine production by T cells. Morgan, R., Gao, G., Pawling, J., Dennis, J.W., Demetriou, M., Li, B. J. Immunol. (2004)
- CD22 antigen: biosynthesis, glycosylation and surface expression of a B lymphocyte protein involved in B cell activation and adhesion. Schwartz-Albiez, R., Dörken, B., Monner, D.A., Moldenhauer, G. Int. Immunol. (1991)
- Comparison of biological activity among nonfucosylated therapeutic IgG1 antibodies with three different N-linked Fc oligosaccharides: the high-mannose, hybrid, and complex types. Kanda, Y., Yamada, T., Mori, K., Okazaki, A., Inoue, M., Kitajima-Miyama, K., Kuni-Kamochi, R., Nakano, R., Yano, K., Kakita, S., Shitara, K., Satoh, M. Glycobiology (2007)
- Disruption of Plasmodium falciparum-infected erythrocyte cytoadherence to human melanoma cells with inhibitors of glycoprotein processing. Wright, P.S., Cross-Doersen, D.E., Schroeder, K.K., Bowlin, T.L., McCann, P.P., Bitonti, A.J. Biochem. Pharmacol. (1991)
- Evaluation of the effects of swainsonine, captopril, tangeretin and nobiletin on the biological behaviour of brain tumour cells in vitro. Rooprai, H.K., Kandanearatchi, A., Maidment, S.L., Christidou, M., Trillo-Pazos, G., Dexter, D.T., Rucklidge, G.J., Widmer, W., Pilkington, G.J. Neuropathol. Appl. Neurobiol. (2001)
- Role of target cell glycoproteins in sensitivity to natural killer cell lysis. Ahrens, P.B. J. Biol. Chem. (1993)
- N-linked oligosaccharides on free alpha interfere with its ability to combine with human chorionic gonadotropin-beta subunit. Blithe, D.L. J. Biol. Chem. (1990)
- Dependence of mouse thymocyte-erythrocyte rosette formation on complete identity at class-I-MHC. Sem, A., Sambhara, S., Chadwick, B.S., Miller, R.G. J. Cell. Physiol. (1991)