Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Chemical Compound Review:

Calendic acid (8E,10E,12Z)-octadeca- 8,10,12-trienoic acid

Synonyms: LMFA01030144, AC1NR0VK, C18:3n-6,8,10, 5204-87-5, alpha-calendic acid, ...

Cahoon, E.B. et al., Reed, D.W. et al., Chardigny, J.M. et al.

Cahoon, Ripp, Hall, Kinney, Chardigny, Hasselwander, Genty, Kraemer, Ptock, Sébédio,

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High impact information on LMFA01030144

Here, we report a class of FAD2-related enzymes that modifies a Delta(9)-double bond to produce the conjugated trans-Delta(8),trans-Delta(10)-double bonds found in calendic acid (18:3Delta(8trans,10trans,12cis)), the major component of the seed oil of Calendula officinalis [1].
Calendic acid significantly decreased body fat content in males [2].
The mechanism by which the fatty acid (1,4)-desaturase of Calendula officinalis produces calendic acid from linoleic acid has been probed through the use of kinetic isotope effect (KIE) measurements [3].

References

Formation of conjugated delta8,delta10-double bonds by delta12-oleic-acid desaturase-related enzymes: biosynthetic origin of calendic acid. Cahoon, E.B., Ripp, K.G., Hall, S.E., Kinney, A.J. J. Biol. Chem. (2001) [Pubmed]
Effect of conjugated FA on feed intake, body composition, and liver FA in mice. Chardigny, J.M., Hasselwander, O., Genty, M., Kraemer, K., Ptock, A., Sébédio, J.L. Lipids (2003) [Pubmed]
Mechanism of 1,4-dehydrogenation catalyzed by a fatty acid (1,4)-desaturase of Calendula officinalis. Reed, D.W., Savile, C.K., Qiu, X., Buist, P.H., Covello, P.S. Eur. J. Biochem. (2002) [Pubmed]

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