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Chemical Compound Review

AC1NRCMD     2-[[(2R)-2,3-bis[[(E)- octadec-8...

Synonyms: 7786-EP2311826A2, 7786-EP2316905A1, 7786-EP2316906A2, DIOLEOYL-PHOSPHATIDYLCHOLINE
 
 
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High impact information on DIOLEOYL-PHOSPHATIDYLCHOLINE

  • The recently devised Low Temperature Trap method was used to prepare compositionally uniform cholesterol/DOPC liposomes to avoid the problem of lipid demixing [1].
  • For all three surfaces, additional adsorption of DOPC (but not DOPS/DOPC) vesicles to condensed membranes was observed [2].
  • DOPC membranes on mica were rapidly degraded by phospholipase A2 (PLA2), which pleads against the role of membrane defects as initial PLA2 targets [2].
  • Mixtures of cholesterol and synthetic phospholipids, differing in saturation of phosphatidylcholine (PC) acyl chains, such as distearoyl phosphatidylcholine (DSPC), stearoyl-oleoyl phosphatidylcholine (SOPC) and dioleoyl phosphatidylcholine (DOPC) have been studied as floating Langmuir monolayers at the air/water interface [3].

References

  1. Lateral distribution of cholesterol in dioleoylphosphatidylcholine lipid bilayers: cholesterol-phospholipid interactions at high cholesterol limit. Parker, A., Miles, K., Cheng, K.H., Huang, J. Biophys. J. (2004) [Pubmed]
  2. Surface-dependent transitions during self-assembly of phospholipid membranes on mica, silica, and glass. Benes, M., Billy, D., Benda, A., Speijer, H., Hof, M., Hermens, W.T. Langmuir : the ACS journal of surfaces and colloids. (2004) [Pubmed]
  3. Interactions between phosphatidylcholines and cholesterol in monolayers at the air/water interface. Dynarowicz-Łatka, P., Hac-Wydro, K. Colloids and surfaces. B, Biointerfaces. (2004) [Pubmed]
 
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