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Chemical Compound Review

POPC     2-[[(2R)-3-hexadecanoyloxy-2- [(Z)-octadec...

Synonyms: Ptd-Cho, AC1NUZHO, Brain PC, Egg PC, CHEBI:73001, ...
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Disease relevance of LMGP01010005

 

Psychiatry related information on LMGP01010005

 

High impact information on LMGP01010005

 

Chemical compound and disease context of LMGP01010005

 

Biological context of LMGP01010005

 

Anatomical context of LMGP01010005

 

Associations of LMGP01010005 with other chemical compounds

 

Gene context of LMGP01010005

  • MDR1 P-glycoprotein is a lipid translocase of broad specificity, while MDR3 P-glycoprotein specifically translocates phosphatidylcholine [12].
  • Independent characterization of the SEC14 gene and the PIT1 gene, which encodes a phosphatidylinositol/phosphatidylcholine transfer protein in yeast, indicated that these two genes are identical [30].
  • Mutations in the SAC1 gene exhibit allele-specific genetic interactions with yeast actin structural gene defects and effect a bypass of the cellular requirement for the yeast phosphatidylinositol/phosphatidylcholine transfer protein (SEC14p), a protein whose function is essential for sustained Golgi secretory function [31].
  • Details of coat protein assembly and Sec16p-stimulated vesicle budding were explored with synthetic liposomes composed of a mixture of lipids, including acidic phospholipids (major-minor mix), or a simple binary mixture of phosphatidylcholine (PC) and phosphatidylethanolamine (PE) [32].
  • Comparative lipid-binding studies with dimyristoyl phosphatidylcholine gave complexes for native and synthetic apoprotein which floated at the same density after ultracentrifugation in KBr gradients and had virtually the same lipid:protein ratios [33].
 

Analytical, diagnostic and therapeutic context of LMGP01010005

References

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  2. High-resolution (1.5 A) crystal structure of phospholipase C from Bacillus cereus. Hough, E., Hansen, L.K., Birknes, B., Jynge, K., Hansen, S., Hordvik, A., Little, C., Dodson, E., Derewenda, Z. Nature (1989) [Pubmed]
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  12. MDR1 P-glycoprotein is a lipid translocase of broad specificity, while MDR3 P-glycoprotein specifically translocates phosphatidylcholine. van Helvoort, A., Smith, A.J., Sprong, H., Fritzsche, I., Schinkel, A.H., Borst, P., van Meer, G. Cell (1996) [Pubmed]
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  14. TNF activates NF-kappa B by phosphatidylcholine-specific phospholipase C-induced "acidic" sphingomyelin breakdown. Schütze, S., Potthoff, K., Machleidt, T., Berkovic, D., Wiegmann, K., Krönke, M. Cell (1992) [Pubmed]
  15. Phospholipase C-mediated hydrolysis of phosphatidylcholine is an important step in PDGF-stimulated DNA synthesis. Larrodera, P., Cornet, M.E., Diaz-Meco, M.T., Lopez-Barahona, M., Diaz-Laviada, I., Guddal, P.H., Johansen, T., Moscat, J. Cell (1990) [Pubmed]
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  17. Defective regulation of phosphatidylcholine-specific phospholipases C and D in a kindred with Tangier disease. Evidence for the involvement of phosphatidylcholine breakdown in HDL-mediated cholesterol efflux mechanisms. Walter, M., Reinecke, H., Gerdes, U., Nofer, J.R., Höbbel, G., Seedorf, U., Assmann, G. J. Clin. Invest. (1996) [Pubmed]
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  19. Leukotriene D4-induced contraction of cat esophageal and lower esophageal sphincter circular smooth muscle. Kim, N., Cao, W., Song, I.S., Kim, C.Y., Sohn, U.D., Harnett, K.M., Biancani, P. Gastroenterology (1998) [Pubmed]
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  22. Bacterial inhibition of phosphatidylcholine synthesis triggers apoptosis in the brain. Zweigner, J., Jackowski, S., Smith, S.H., Van Der Merwe, M., Weber, J.R., Tuomanen, E.I. J. Exp. Med. (2004) [Pubmed]
  23. Interleukin-1 stimulates diacylglycerol production in T lymphocytes by a novel mechanism. Rosoff, P.M., Savage, N., Dinarello, C.A. Cell (1988) [Pubmed]
  24. Saturated phosphatidylcholine in amniotic fluid and prediction of the respiratory-distress syndrome. Torday, J., Carson, L., Lawson, E.E. N. Engl. J. Med. (1979) [Pubmed]
  25. Assembly of the endoplasmic reticulum phospholipid bilayer: the phosphatidylcholine transporter. Bishop, W.R., Bell, R.M. Cell (1985) [Pubmed]
  26. Essential role for diacylglycerol in protein transport from the yeast Golgi complex. Kearns, B.G., McGee, T.P., Mayinger, P., Gedvilaite, A., Phillips, S.E., Kagiwada, S., Bankaitis, V.A. Nature (1997) [Pubmed]
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  31. SAC1p is an integral membrane protein that influences the cellular requirement for phospholipid transfer protein function and inositol in yeast. Whitters, E.A., Cleves, A.E., McGee, T.P., Skinner, H.B., Bankaitis, V.A. J. Cell Biol. (1993) [Pubmed]
  32. Sec16p potentiates the action of COPII proteins to bud transport vesicles. Supek, F., Madden, D.T., Hamamoto, S., Orci, L., Schekman, R. J. Cell Biol. (2002) [Pubmed]
  33. The solid phase synthesis of a protein activator for lecithin-cholesterol acyltransferase corresponding to human plasma apoC-I. Sigler, G.F., Soutar, A.K., Smith, L.C., Gotto, A.M., Sparrow, J.T. Proc. Natl. Acad. Sci. U.S.A. (1976) [Pubmed]
  34. Interfacial activation of the lipase-procolipase complex by mixed micelles revealed by X-ray crystallography. van Tilbeurgh, H., Egloff, M.P., Martinez, C., Rugani, N., Verger, R., Cambillau, C. Nature (1993) [Pubmed]
  35. Intraamniotic interleukin-1 accelerates surfactant protein synthesis in fetal rabbits and improves lung stability after premature birth. Bry, K., Lappalainen, U., Hallman, M. J. Clin. Invest. (1997) [Pubmed]
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