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Chemical Compound Review

POPC     2-[[(2R)-3-hexadecanoyloxy-2- [(Z)-octadec...

Synonyms: Ptd-Cho, AC1NUZHO, Brain PC, Egg PC, CHEBI:73001, ...
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Disease relevance of LMGP01010005


Psychiatry related information on LMGP01010005


High impact information on LMGP01010005


Chemical compound and disease context of LMGP01010005


Biological context of LMGP01010005


Anatomical context of LMGP01010005


Associations of LMGP01010005 with other chemical compounds


Gene context of LMGP01010005

  • MDR1 P-glycoprotein is a lipid translocase of broad specificity, while MDR3 P-glycoprotein specifically translocates phosphatidylcholine [12].
  • Independent characterization of the SEC14 gene and the PIT1 gene, which encodes a phosphatidylinositol/phosphatidylcholine transfer protein in yeast, indicated that these two genes are identical [30].
  • Mutations in the SAC1 gene exhibit allele-specific genetic interactions with yeast actin structural gene defects and effect a bypass of the cellular requirement for the yeast phosphatidylinositol/phosphatidylcholine transfer protein (SEC14p), a protein whose function is essential for sustained Golgi secretory function [31].
  • Details of coat protein assembly and Sec16p-stimulated vesicle budding were explored with synthetic liposomes composed of a mixture of lipids, including acidic phospholipids (major-minor mix), or a simple binary mixture of phosphatidylcholine (PC) and phosphatidylethanolamine (PE) [32].
  • Comparative lipid-binding studies with dimyristoyl phosphatidylcholine gave complexes for native and synthetic apoprotein which floated at the same density after ultracentrifugation in KBr gradients and had virtually the same lipid:protein ratios [33].

Analytical, diagnostic and therapeutic context of LMGP01010005


  1. Sequential changes of surfactant phosphatidylcholine in hyaline-membrane disease of the newborn. Shelley, S.A., Kovacevic, M., Paciga, J.E., Balis, J.U. N. Engl. J. Med. (1979) [Pubmed]
  2. High-resolution (1.5 A) crystal structure of phospholipase C from Bacillus cereus. Hough, E., Hansen, L.K., Birknes, B., Jynge, K., Hansen, S., Hordvik, A., Little, C., Dodson, E., Derewenda, Z. Nature (1989) [Pubmed]
  3. Choline metabolism as a basis for the selective vulnerability of cholinergic neurons. Wurtman, R.J. Trends Neurosci. (1992) [Pubmed]
  4. Phosphatidyl choline is recognized by a series of Ly-1+ murine B cell lymphomas specific for erythrocyte membranes. Mercolino, T.J., Arnold, L.W., Haughton, G. J. Exp. Med. (1986) [Pubmed]
  5. Electrophysiologic effects of intracellular lysophosphoglycerides and their accumulation in cardiac lymph with myocardial ischemia in dogs. Akita, H., Creer, M.H., Yamada, K.A., Sobel, B.E., Corr, P.B. J. Clin. Invest. (1986) [Pubmed]
  6. Plasma phosphatidylcholine docosahexaenoic Acid content and risk of dementia and Alzheimer disease: the framingham heart study. Schaefer, E.J., Bongard, V., Beiser, A.S., Lamon-Fava, S., Robins, S.J., Au, R., Tucker, K.L., Kyle, D.J., Wilson, P.W., Wolf, P.A. Arch. Neurol. (2006) [Pubmed]
  7. Origin of the lag period in the phospholipase C cleavage of phospholipids in membranes. Concomitant vesicle aggregation and enzyme activation. Basáñez, G., Nieva, J.L., Goñi, F.M., Alonso, A. Biochemistry (1996) [Pubmed]
  8. Hepatic phosphatidylethanolamine methyltransferase activity is decreased by ethanol and increased by phosphatidylcholine. Lieber, C.S., Robins, S.J., Leo, M.A. Alcohol. Clin. Exp. Res. (1994) [Pubmed]
  9. Action of cobra venom phospholipase A2 on large unilamellar vesicles: comparison with small unilamellar vesicles and multibilayers. Kensil, C.R., Dennis, E.A. Lipids (1985) [Pubmed]
  10. Membrane abnormalities in the psychoses and affective disorders. Hitzemann, R., Hirschowitz, J., Garver, D. Journal of psychiatric research. (1984) [Pubmed]
  11. Phospholipase D: enzymology, mechanisms of regulation, and function. Exton, J.H. Physiol. Rev. (1997) [Pubmed]
  12. MDR1 P-glycoprotein is a lipid translocase of broad specificity, while MDR3 P-glycoprotein specifically translocates phosphatidylcholine. van Helvoort, A., Smith, A.J., Sprong, H., Fritzsche, I., Schinkel, A.H., Borst, P., van Meer, G. Cell (1996) [Pubmed]
  13. Phosphatidylcholine translocase: a physiological role for the mdr2 gene. Ruetz, S., Gros, P. Cell (1994) [Pubmed]
  14. TNF activates NF-kappa B by phosphatidylcholine-specific phospholipase C-induced "acidic" sphingomyelin breakdown. Schütze, S., Potthoff, K., Machleidt, T., Berkovic, D., Wiegmann, K., Krönke, M. Cell (1992) [Pubmed]
  15. Phospholipase C-mediated hydrolysis of phosphatidylcholine is an important step in PDGF-stimulated DNA synthesis. Larrodera, P., Cornet, M.E., Diaz-Meco, M.T., Lopez-Barahona, M., Diaz-Laviada, I., Guddal, P.H., Johansen, T., Moscat, J. Cell (1990) [Pubmed]
  16. Membrane lipids of hepatic tissue. II. Phospholipids from subcellular fractions of liver and hepatoma 7288CTC. Upreti, G.C., deAntueno, R.J., Wood, R. J. Natl. Cancer Inst. (1983) [Pubmed]
  17. Defective regulation of phosphatidylcholine-specific phospholipases C and D in a kindred with Tangier disease. Evidence for the involvement of phosphatidylcholine breakdown in HDL-mediated cholesterol efflux mechanisms. Walter, M., Reinecke, H., Gerdes, U., Nofer, J.R., Höbbel, G., Seedorf, U., Assmann, G. J. Clin. Invest. (1996) [Pubmed]
  18. Role of biliary phosphatidylcholine in the absorption and transport of dietary triolein in the rat. Tso, P., Kendrick, H., Balint, J.A., Simmonds, W.J. Gastroenterology (1981) [Pubmed]
  19. Leukotriene D4-induced contraction of cat esophageal and lower esophageal sphincter circular smooth muscle. Kim, N., Cao, W., Song, I.S., Kim, C.Y., Sohn, U.D., Harnett, K.M., Biancani, P. Gastroenterology (1998) [Pubmed]
  20. Influence of cytoskeletal assembly on phosphatidylcholine synthesis in intact phagocytic cells. Pike, M.C., Kredich, N.M., Snyderman, R. Cell (1980) [Pubmed]
  21. The role of lipid signaling in constitutive membrane traffic. Roth, M.G., Sternweis, P.C. Curr. Opin. Cell Biol. (1997) [Pubmed]
  22. Bacterial inhibition of phosphatidylcholine synthesis triggers apoptosis in the brain. Zweigner, J., Jackowski, S., Smith, S.H., Van Der Merwe, M., Weber, J.R., Tuomanen, E.I. J. Exp. Med. (2004) [Pubmed]
  23. Interleukin-1 stimulates diacylglycerol production in T lymphocytes by a novel mechanism. Rosoff, P.M., Savage, N., Dinarello, C.A. Cell (1988) [Pubmed]
  24. Saturated phosphatidylcholine in amniotic fluid and prediction of the respiratory-distress syndrome. Torday, J., Carson, L., Lawson, E.E. N. Engl. J. Med. (1979) [Pubmed]
  25. Assembly of the endoplasmic reticulum phospholipid bilayer: the phosphatidylcholine transporter. Bishop, W.R., Bell, R.M. Cell (1985) [Pubmed]
  26. Essential role for diacylglycerol in protein transport from the yeast Golgi complex. Kearns, B.G., McGee, T.P., Mayinger, P., Gedvilaite, A., Phillips, S.E., Kagiwada, S., Bankaitis, V.A. Nature (1997) [Pubmed]
  27. Vesicle targeting: timed release and specificity for leukocytes in mice by subcutaneous injection. Mauk, M.R., Gamble, R.C., Baldeschwieler, J.D. Science (1980) [Pubmed]
  28. Phospholipid methylation unmasks cryptic beta-adrenergic receptors in rat reticulocytes. Strittmatter, W.J., Hirata, F., Axelrod, J. Science (1979) [Pubmed]
  29. Crystal structure of human BPI and two bound phospholipids at 2.4 angstrom resolution. Beamer, L.J., Carroll, S.F., Eisenberg, D. Science (1997) [Pubmed]
  30. An essential role for a phospholipid transfer protein in yeast Golgi function. Bankaitis, V.A., Aitken, J.R., Cleves, A.E., Dowhan, W. Nature (1990) [Pubmed]
  31. SAC1p is an integral membrane protein that influences the cellular requirement for phospholipid transfer protein function and inositol in yeast. Whitters, E.A., Cleves, A.E., McGee, T.P., Skinner, H.B., Bankaitis, V.A. J. Cell Biol. (1993) [Pubmed]
  32. Sec16p potentiates the action of COPII proteins to bud transport vesicles. Supek, F., Madden, D.T., Hamamoto, S., Orci, L., Schekman, R. J. Cell Biol. (2002) [Pubmed]
  33. The solid phase synthesis of a protein activator for lecithin-cholesterol acyltransferase corresponding to human plasma apoC-I. Sigler, G.F., Soutar, A.K., Smith, L.C., Gotto, A.M., Sparrow, J.T. Proc. Natl. Acad. Sci. U.S.A. (1976) [Pubmed]
  34. Interfacial activation of the lipase-procolipase complex by mixed micelles revealed by X-ray crystallography. van Tilbeurgh, H., Egloff, M.P., Martinez, C., Rugani, N., Verger, R., Cambillau, C. Nature (1993) [Pubmed]
  35. Intraamniotic interleukin-1 accelerates surfactant protein synthesis in fetal rabbits and improves lung stability after premature birth. Bry, K., Lappalainen, U., Hallman, M. J. Clin. Invest. (1997) [Pubmed]
  36. Thyroid hormone stimulation of phosphatidylcholine synthesis in cultured fetal rabbit lung. Ballard, P.L., Hovey, M.L., Gonzales, L.K. J. Clin. Invest. (1984) [Pubmed]
  37. Surfactant replacement therapy in late-stage adult respiratory distress syndrome. Haslam, P.L., Hughes, D.A., MacNaughton, P.D., Baker, C.S., Evans, T.W. Lancet (1994) [Pubmed]
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