Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Chemical Compound Review:

AC1NSJU2 (5S,6R,7E,9E,11Z,14Z)-6-(4...

Synonyms: BAYu9773, CHEMBL285954, B9680_SIGMA, Bay u9773

Di Gennaro, A. et al., Hui, Y. et al.

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High impact information on BAYu9773

[(3)H]LTD(4) binding to membranes expressing mCysLT(2)R could be effectively competed by LTC(4) and LTD(4) and only partially inhibited by LTE(4) and BAYu9773 [1].
The dual cysLT1-cysLT2 receptor antagonist BAYu9773 was more potent and more effective than a selective cysLT1 antagonist in preventing the brain permeability alteration induced by neutrophil activation [2].

References

The murine cysteinyl leukotriene 2 (CysLT2) receptor. cDNA and genomic cloning, alternative splicing, and in vitro characterization. Hui, Y., Yang, G., Galczenski, H., Figueroa, D.J., Austin, C.P., Copeland, N.G., Gilbert, D.J., Jenkins, N.A., Funk, C.D. J. Biol. Chem. (2001) [Pubmed]
Cysteinyl-leukotrienes receptor activation in brain inflammatory reactions and cerebral edema formation: a role for transcellular biosynthesis of cysteinyl-leukotrienes. Di Gennaro, A., Carnini, C., Buccellati, C., Ballerio, R., Zarini, S., Fumagalli, F., Viappiani, S., Librizzi, L., Hernandez, A., Murphy, R.C., Constantin, G., De Curtis, M., Folco, G., Sala, A. FASEB J. (2004) [Pubmed]

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