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Chemical Compound Review

AC1NSK3B     N-[(1S)-3-methyl-1-[[3-oxo-1- [2-(3-pyridin...

Synonyms: SB-331750
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Disease relevance of SB-331750

  • In an in situ enzyme assay, SB 331750 inhibited osteoclast-associated cathepsin activity in tissue sections containing human osteoclasts (IC(50) approximately 60 nmol/L) and this translated into potent inhibition of human osteoclast-mediated bone resorption in vitro (IC(50) approximately 30 nmol/L) [1].

High impact information on SB-331750


Anatomical context of SB-331750

  • Histological evaluation of the bones from compound-treated animals indicated that SB 331750 retarded bone matrix degradation in vivo at all three doses [1].


  1. A potent small molecule, nonpeptide inhibitor of cathepsin K (SB 331750) prevents bone matrix resorption in the ovariectomized rat. Lark, M.W., Stroup, G.B., James, I.E., Dodds, R.A., Hwang, S.M., Blake, S.M., Lechowska, B.A., Hoffman, S.J., Smith, B.R., Kapadia, R., Liang, X., Erhard, K., Ru, Y., Dong, X., Marquis, R.W., Veber, D., Gowen, M. Bone (2002) [Pubmed]
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