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MeSH Review


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Disease relevance of Hypercalcemia


Psychiatry related information on Hypercalcemia


High impact information on Hypercalcemia

  • In contrast to the situation in humoral hypercalcemia of malignancy in which PTHrP plays the role of a classical "endocrine" hormone, under normal circumstances PTHrP plays predominantly paracrine and/or autocrine roles [1].
  • BACKGROUND: Once-daily injections of parathyroid hormone or its amino-terminal fragments increase bone formation and bone mass without causing hypercalcemia, but their effects on fractures are unknown [8].
  • BACKGROUND: An activating mutation of the receptor for parathyroid hormone (PTH) and parathyroid hormone-related peptide (PTHrP) was recently found in a patient with Jansens's metaphyseal chondrodysplasia, a rare form of short-limbed dwarfism associated with hypercalcemia and normal or low serum concentrations of the two hormones [9].
  • A mouse model of human familial hypocalciuric hypercalcemia and neonatal severe hyperparathyroidism [10].
  • It appears that production of the bone-resorbing cytokine lymphotoxin is related to osteoclastic bone destruction and hypercalcemia in patients with myeloma [11].

Chemical compound and disease context of Hypercalcemia


Biological context of Hypercalcemia


Anatomical context of Hypercalcemia


Gene context of Hypercalcemia


Analytical, diagnostic and therapeutic context of Hypercalcemia


  1. Defining the roles of parathyroid hormone-related protein in normal physiology. Philbrick, W.M., Wysolmerski, J.J., Galbraith, S., Holt, E., Orloff, J.J., Yang, K.H., Vasavada, R.C., Weir, E.C., Broadus, A.E., Stewart, A.F. Physiol. Rev. (1996) [Pubmed]
  2. Acute myelobalstic leukemia and hypercalcemia. A case of probable ectopic parathyroid hormone production. Zidar, B.L., Shadduck, R.K., Winkelstein, A., Zeigler, Z., Hawker, C.D. N. Engl. J. Med. (1976) [Pubmed]
  3. Intravenous calcitriol in the treatment of refractory osteitis fibrosa of chronic renal failure. Andress, D.L., Norris, K.C., Coburn, J.W., Slatopolsky, E.A., Sherrard, D.J. N. Engl. J. Med. (1989) [Pubmed]
  4. Elevated plasma 1,25-dihydroxyvitamin D concentrations in infants with hypercalcemia and an elfin facies. Garabédian, M., Jacqz, E., Guillozo, H., Grimberg, R., Guillot, M., Gagnadoux, M.F., Broyer, M., Lenoir, G., Balsan, S. N. Engl. J. Med. (1985) [Pubmed]
  5. Normal parathyroid hormone activity in hypercalcemia associated with thrombotic thrombocytopenic purpura. Michaeli, J., Lugassy, G., Bassan, M. N. Engl. J. Med. (1983) [Pubmed]
  6. TFII-I, a candidate gene for Williams syndrome cognitive profile: parallels between regional expression in mouse brain and human phenotype. Danoff, S.K., Taylor, H.E., Blackshaw, S., Desiderio, S. Neuroscience (2004) [Pubmed]
  7. Lithium increases tritiated thymidine uptake by abnormal human parathyroid tissue. Saxe, A.W., Gibson, G. Surgery (1991) [Pubmed]
  8. Effect of parathyroid hormone (1-34) on fractures and bone mineral density in postmenopausal women with osteoporosis. Neer, R.M., Arnaud, C.D., Zanchetta, J.R., Prince, R., Gaich, G.A., Reginster, J.Y., Hodsman, A.B., Eriksen, E.F., Ish-Shalom, S., Genant, H.K., Wang, O., Mitlak, B.H. N. Engl. J. Med. (2001) [Pubmed]
  9. Constitutively activated receptors for parathyroid hormone and parathyroid hormone-related peptide in Jansen's metaphyseal chondrodysplasia. Schipani, E., Langman, C.B., Parfitt, A.M., Jensen, G.S., Kikuchi, S., Kooh, S.W., Cole, W.G., Jüppner, H. N. Engl. J. Med. (1996) [Pubmed]
  10. A mouse model of human familial hypocalciuric hypercalcemia and neonatal severe hyperparathyroidism. Ho, C., Conner, D.A., Pollak, M.R., Ladd, D.J., Kifor, O., Warren, H.B., Brown, E.M., Seidman, J.G., Seidman, C.E. Nat. Genet. (1995) [Pubmed]
  11. Production of lymphotoxin, a bone-resorbing cytokine, by cultured human myeloma cells. Garrett, I.R., Durie, B.G., Nedwin, G.E., Gillespie, A., Bringman, T., Sabatini, M., Bertolini, D.R., Mundy, G.R. N. Engl. J. Med. (1987) [Pubmed]
  12. Bone response to phosphate salts, ergocalciferol, and calcitriol in hypophosphatemic vitamin D-resistant rickets. Glorieux, F.H., Marie, P.J., Pettifor, J.M., Delvin, E.E. N. Engl. J. Med. (1980) [Pubmed]
  13. Hypercalcemia and increases in serum hormone value during prolonged administration of 1alpha,25-dihydroxyvitamin D. Bell, N.H., Stern, P.H. N. Engl. J. Med. (1978) [Pubmed]
  14. Prostaglandins as mediators of hypercalcemia associated with certain types of cancer. Seyberth, H.W., Segre, G.V., Morgan, J.L., Sweetman, B.J., Potts, J.T., Oates, J.A. N. Engl. J. Med. (1975) [Pubmed]
  15. Letter: Indomethacin-responsive hypercalcemia. Ito, H., Sanada, T., Katayama, T., Shimazaki, J. N. Engl. J. Med. (1975) [Pubmed]
  16. Biochemical evaluation of patients with cancer-associated hypercalcemia: evidence for humoral and nonhumoral groups. Stewart, A.F., Horst, R., Deftos, L.J., Cadman, E.C., Lang, R., Broadus, A.E. N. Engl. J. Med. (1980) [Pubmed]
  17. Calcium-sensing receptor mutations in familial benign hypercalcemia and neonatal hyperparathyroidism. Pearce, S.H., Trump, D., Wooding, C., Besser, G.M., Chew, S.L., Grant, D.B., Heath, D.A., Hughes, I.A., Paterson, C.R., Whyte, M.P. J. Clin. Invest. (1995) [Pubmed]
  18. Familial hypocalciuric hypercalcemia and neonatal severe hyperparathyroidism. Effects of mutant gene dosage on phenotype. Pollak, M.R., Chou, Y.H., Marx, S.J., Steinmann, B., Cole, D.E., Brandi, M.L., Papapoulos, S.E., Menko, F.H., Hendy, G.N., Brown, E.M. J. Clin. Invest. (1994) [Pubmed]
  19. Markedly reduced activity of mutant calcium-sensing receptor with an inserted Alu element from a kindred with familial hypocalciuric hypercalcemia and neonatal severe hyperparathyroidism. Bai, M., Janicic, N., Trivedi, S., Quinn, S.J., Cole, D.E., Brown, E.M., Hendy, G.N. J. Clin. Invest. (1997) [Pubmed]
  20. Hypercalcemia stimulates expression of intrarenal phospholipase A2 and prostaglandin H synthase-2 in rats. Role of angiotensin II AT1 receptors. Mangat, H., Peterson, L.N., Burns, K.D. J. Clin. Invest. (1997) [Pubmed]
  21. Comparison of postreceptor effects of 1-34 human hypercalcemia factor and 1-34 human parathyroid hormone in rat osteosarcoma cells. Rodan, S.B., Noda, M., Wesolowski, G., Rosenblatt, M., Rodan, G.A. J. Clin. Invest. (1988) [Pubmed]
  22. A parathyroid hormone-like protein from cultured human keratinocytes. Merendino, J.J., Insogna, K.L., Milstone, L.M., Broadus, A.E., Stewart, A.F. Science (1986) [Pubmed]
  23. Interleukin-6 enhances hypercalcemia and bone resorption mediated by parathyroid hormone-related protein in vivo. de la Mata, J., Uy, H.L., Guise, T.A., Story, B., Boyce, B.F., Mundy, G.R., Roodman, G.D. J. Clin. Invest. (1995) [Pubmed]
  24. Increased calcium intake does not suppress circulating 1,25-dihydroxyvitamin D in normocalcemic patients with sarcoidosis. Basile, J.N., Liel, Y., Shary, J., Bell, N.H. J. Clin. Invest. (1993) [Pubmed]
  25. Prostaglandin G/H synthase-2 is required for maximal formation of osteoclast-like cells in culture. Okada, Y., Lorenzo, J.A., Freeman, A.M., Tomita, M., Morham, S.G., Raisz, L.G., Pilbeam, C.C. J. Clin. Invest. (2000) [Pubmed]
  26. The influence of hypercalcemia on basal and cholecystokinin-stimulated pancreatic, gallbladder, and gastric functions in man. Malagelada, J.R., Holtermuller, K.H., Sizemore, G.W., Go, V.L. Gastroenterology (1976) [Pubmed]
  27. Effects of a synthetic peptide of a parathyroid hormone-related protein on calcium homeostasis, renal tubular calcium reabsorption, and bone metabolism in vivo and in vitro in rodents. Yates, A.J., Gutierrez, G.E., Smolens, P., Travis, P.S., Katz, M.S., Aufdemorte, T.B., Boyce, B.F., Hymer, T.K., Poser, J.W., Mundy, G.R. J. Clin. Invest. (1988) [Pubmed]
  28. Interleukin 1 gene expression in adult T cell leukemia. Wano, Y., Hattori, T., Matsuoka, M., Takatsuki, K., Chua, A.O., Gubler, U., Greene, W.C. J. Clin. Invest. (1987) [Pubmed]
  29. Targeted overexpression of parathyroid hormone-related peptide in chondrocytes causes chondrodysplasia and delayed endochondral bone formation. Weir, E.C., Philbrick, W.M., Amling, M., Neff, L.A., Baron, R., Broadus, A.E. Proc. Natl. Acad. Sci. U.S.A. (1996) [Pubmed]
  30. Impaired cotranslational processing of the calcium-sensing receptor due to signal peptide missense mutations in familial hypocalciuric hypercalcemia. Pidasheva, S., Canaff, L., Simonds, W.F., Marx, S.J., Hendy, G.N. Hum. Mol. Genet. (2005) [Pubmed]
  31. Failure of parathyroid hormone antagonists to inhibit in vitro bone resorbing activity produced by two animal models of the humoral hypercalcemia of malignancy. D'Souza, S.M., Ibbotson, K.J., Mundy, G.R. J. Clin. Invest. (1984) [Pubmed]
  32. Evidence for a parathyroid hormone-dependent influence of calcium on the glomerular ultrafiltration coefficient. Humes, H.D., Ichikawa, I., Troy, J.L., Brenner, B.M. J. Clin. Invest. (1978) [Pubmed]
  33. Pancreatitis in association with hypercalcemia in patients receiving total parenteral nutrition. Izsak, E.M., Shike, M., Roulet, M., Jeejeebhoy, K.N. Gastroenterology (1980) [Pubmed]
  34. Inhibitory effect of 220-oxa-1,25-dihydroxyvitamin D3 on the proliferation of pancreatic cancer cell lines. Kawa, S., Yoshizawa, K., Tokoo, M., Imai, H., Oguchi, H., Kiyosawa, K., Homma, T., Nikaido, T., Furihata, K. Gastroenterology (1996) [Pubmed]
  35. Persistent severe hypercalcemia during maintenance hemodialysis. Johnson, W.J. Ann. Intern. Med. (1980) [Pubmed]
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