Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Chemical Compound Review:

AC1NSO0Q (5E,8Z,11Z,13Z,15R)-15- hydroxyicosa-5,8,11...

Synonyms: LMFA03060067, 15(R)-HETE, 15(R)-Hydroxyeicosatetraenoic acid

Lee, S.H. et al., Mancini, J.A. et al.

Mancini, Vickers, O'Neill, Boily, Falgueyret, Riendeau,

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High impact information on 15(R)-HETE

Aspirin (ASA) acetylates Ser516 of prostaglandin G/H synthase-2 (PGHS-2) resulting in a modified enzyme that converts arachidonic acid to 15(R)-hydroxy-eicosatetraeroic acid [15(R)-HETE] [1].
Inhibition with the non-selective cyclooxygenase inhibitor aspirin increased the formation of 15(R)-hydroxyeicosatetraenoic acid in the cells although it completely inhibited formation of the 15(S)-enantiomer and prostaglandin E2 [2].

References

Altered sensitivity of aspirin-acetylated prostaglandin G/H synthase-2 to inhibition by nonsteroidal anti-inflammatory drugs. Mancini, J.A., Vickers, P.J., O'Neill, G.P., Boily, C., Falgueyret, J.P., Riendeau, D. Mol. Pharmacol. (1997) [Pubmed]
Targeted chiral lipidomics analysis. Lee, S.H., Williams, M.V., Blair, I.A. Prostaglandins Other Lipid Mediat. (2005) [Pubmed]

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